|
      |
|
 Stowers Lecture Series 2000-2009
November 8, 2000 Richard Klausner (National Institutes of Health, National Cancer Institute) November 29, 2000 Doug Cyr ( Roles for Hsp70 in CFTR Folding and Proteosomal Degradation
December 4, 2000 Paul
Trainor (National Institute for Medical Research, Craniofacial Development: The Role of Neural Crest and Hox Gene Plasticity
January 10, 2001 Brian
Sauer ( Cre Recombinase and Mouse Genetics by Design
January 24, 2001 Charles
Little (University of Vasculogenesis: Formation of the First Blood Vessels
January 31, 2001 Glen
Andrews (University of Mechanisms of Regulation of Gene Expression by Zinc
February 7, 2001 Jeff
Price ( Doubletime: A Protein Kinase that Establishes the Molecular Oscillations of Circadian Rhythms February 14, 2001 Skip Garner ( Informatics and Instrumentation for the Post-genome Era
February 21, 2001 Jill
Pelling (University of Molecular Mechanism of Chemoprevention by the Bioflavonoid Apigenin: Post-translational Stabilization of the p53 Tumor Suppressor Protein
February 28, 2001 S.
K. Dey (University of Molecular Signaling in Embryo-Uterine Interactions During Implantation
March 7, 2001 Brian
Livingston ( Regulation of Transcription during Endoderm
Development in Sea Urchins March 14, 2001 Edward
(Ward) Wakeland ( Mouse Genetics in the Context of a Mouse Model of SLE March 21, 2001 Alan
Godwin (University of Hoxc
13: Hair Today, Gone Tomorrow
March
28, 2001 Kelley
Thomas (University of Mutation Accumulation in the c.Elegans Genome April 11, 2001 Barry
Festoff (University of Conformational
Neurodegenerative Diseases: Role of
Proteases and Transglutaminases in Model Systems
May 2, 2001 Luis Parada ( Neurotrophin
Ligands and their Receptors in the Survival of Early Neurons May 9, 2001 Bruce Lahn (University of Chicago, Howard Hughes Medical Institute) Comparative Genomics: A New Tool for Studying Genome Function
and Evolution May 16, 2001 Randy
Johnson ( Vertebrate Segmentation and Pattern Formation May 30, 2001 Thom Kaufman (Indiana University, Howard Hughes Medical Institute) Hox
Genes and the Arthopodan Bauplan June 6, 2001 Alfred G. Gilman (
September 5, 2001 Alan Spradling (Carnegie Institute) Regulation
of Cell Differentiation During Early Stages of Drosophila Oogenesis
September 19, 2001 Stephen Alexander ( Proteomic and Genetic Approaches to studies of Regulated Protein Secretion to Anticancer Drugs
September 26, 2001 Thomas O’Halloran (Northwestern University) Chemical Biology of Intracellular Transition Metals in Human Disease
October 3, 2001 Kevin
Moore ( Biochemistry of Leukocyte-Endothelial Interactions
October 10, 2001 Beth Sullivan (The Salk Institute) Structure and Function of Centromeric Chromatin in Flies and Humans
October 17, 2001 Donald
Riddle ( Genetics of Development and Longevity in C. elegans
October 24, 2001 Ed
Ziff ( Regulating
the Strength of Synapses through Trafficking of Glutamate Receptors November 7, 2001 Robert
Haley ( Gulf War Syndrome: A Toxic Cellular Inquiry to Deep Brain Structures
November 14, 2001 Nancy Bonini (University of Pennsylvania, Howard Hughes Medical Institute) Drosophila as a Model for Human Neurodegenerative Disease
November 28, 2001 Ali Shilatifard
( COMPASS: A SET Domain Containing Trithorax
Related Complex Involved in Transcriptional Regulation and Oncogenesis December 5, 2001 Stan Fields (University of Washington, Howard Hughes Medical Institute) Using Yeast to Analyze the Interactions of Proteins, Nucleic Acids and Small Molecules
December 12, 2001 Joshua Sanes ( Synapse
Formation Analyzed in Fluorescent and Mutant Mice
January 9, 2002 Rick Young (Massachusetts Institute of Technology, Whitehead Institute) Mapping
Genome Regulatory Circuitry January 16, 2002 Scott
Saunders ( Heparan Sulfate Proteoglycans: Master Regulators of Cellular Responsiveness to Growth Factors and Morphogens
January 23, 2002 Gary
Stormo ( Experimental and Computational Methods for Identifying
Regulatory Sites in DNA Sequences February 6, 2002 David
Ornitz ( FGF and FGF Receptor Signaling in Skeletal Development and Genetic Disease February 13, 2002 Joseph
Goldstein and Michael Brown
( How Cells Control Cholesterol
February 20, 2002 Robert
G. Roeder (The Regulation
of Transcription in Animal Cells through the Action of Diverse Coactivators February 27, 2002 Jeffrey
Milbrandt ( Development, Regeneration and Tumorigenesis: Mechanistic Insights from Gene Targeting and Expression Profiling March 6, 2002 Pamela Geyer ( Insulators: A New Class of Elements that Establish Independent Domains of Gene Function March 13, 2002 Mark
Noble ( Pivotal Roles of Redox Regulation in Precursor Cell Function and Neoplasia
March 20, 2002 Steve
Johnson ( How the Zebrafish Gets its Stripes
March 27, 2002 John
Heuser ( The Ultrastructural Basis of Cancer Cell Invasiveness April 3, 2002 Eric
Olson ( Transcriptional
Control of Heart Development and Disease April 10, 2002 Bill
Skarnes ( Functional Analysis of the Mammalian Genome April 17,
2002 Paul
Kelly ( Signaling Pathways that Regulate Synaptic Transmission in BrainApril 24, 2002 Margaret
Baron ( Programming
the Embryo to Make Blood and Vascular Endothelial Cells May 1, 2002 Jiyan Ma ( Exploring
the Cellular Mechanism of Prion Disease:
Misfolding and Retrograde Transport of PrP Generates a Neurotoxic
PrPSc-like Conformation May 8, 2002 Andy
McMahon ( Hedgehog Signaling in the Vertebrate Embryo May 15, 2002 Jerry Workman (Pennsylvania State University, Howard Hughes Medical Institute) Functions
and Interactions of Histone Acetyltransferase Complexes and the SWI/SNF Complex
in Yeast May
22, 2002 Bill
McGinnis ( Hox
Protein Mutation and Macroevolution of the Insect Body Plan May 29, 2002 Natalie
Ahn ( New
Avenues in MAP Kinase Signal Transduction September
4, 2002 Yi
Rao ( September
11, 2002 Mary
Faith Marshall (University of September
18, 2002 Helen
Hobbs ( September
25, 2002 Marianne
Bronner-Fraser (California Institute of Technology) October 2, 2002 Michael
Rosbash (Brandeis University, Howard Hughes Medical Institute)
October
9, 2002 Tom
Petes (
October
16, 2002 Norbert
Perrimon (Harvard Medical School, Howard Hughes Medical Institute)
October
23, 2002 Ian
Willis (
October
30, 2002 Kees
Weijer (Wellcome Trust Biocentre,
November
6, 2002 Oliver
Hobert (
November
13, 2002 Thomas
Sudhof (
November
20, 2002 Ken
Peterson (University of Kansas Medical Center) December 4, 2002 Ting
Xie (Stowers Institute for Medical Research)
December
11, 2002 Ross
Cagan (
January
8, 2003 Jim
Haber (
January
15, 2003 Nahum
Sonenberg (
January
22, 2003 Steven
Henikoff (
January
29, 2003 Jeff
Lichtman (
February
5, 2003 Trudi
Schupbach (Princeton University, Howard Hughes Medical Institute)
February
12, 2003 R.
Sanders Williams (
February
19, 2003 Joseph
Takahashi (Northwestern University)
February
26, 2003 Margaret
Goodell (
March 4, 2003 Monica
Justice (
March 12, 2003 Malcolm
Whitman (
March 19, 2003 Minx
Fuller (
March 26, 2003 Robert
Cohen (
April 2, 2003 Marty
Chalfie (
April 9, 2003 Susan
Lindquist (Whitehead Institute)
April 16, 2003
Steve McKnight (
April 23, 2003 Ruth
Lehmann (Skirball Institute,
May 7, 2003 Winship
Herr (
May 14, 2003 Doug
Koshland (Carnegie Institution of
May 21, 2003 Nancy
Jenkins (National Cancer Institute)
May 22, 2003 Neal
Copeland (National Cancer Institute)
May 28, 2003 Mark
Krasnow ( September 3,
2003 Christopher Burge (Massachusetts
Institute of Technology) Bioinformatics of MicroRNAs September 10,
2003 Nouria Hernandez (Cold Spring Harbor
Laboratory, Howard Hughes Medical Institute) CK2 Regulation of Human RNA Polymerase III Transcription in a Well-Defined in vitro Transcription System September 17,
2003 Philip Needleman ( COX2 Inhibitors: From Discovery to Inflammation and Cancer September 24,
2003 Christopher Wylie (Cincinnati
Children’s Hospital Research Foundation) Germ Cells September 25,
2003 Janet Heasman (Cincinnati
Children’s What
my Mother Told Me: Maternal Control
of Early Xenopus Development October 1, 2003 Elizabeth Robertson ( Making Heads and Tails of the Early
Embryo: TGFb Pathways Regulating Axis Formation in the
Mouse October 15, 2003 David Ish-Horowicz (Cancer Research Taking the A(pical)
Train: Mechanisms and Specificity
of RNA Trafficking in Drosophila October 29, 2003 Kerry Bloom ( Mechanisms of Chromosome Segregation November 5, 2003 Janet Rossant ( Stem Cells and Developmental Pathways in the
Early Mouse Embryo November 12, 2003 Thomas
Jessell ( Control of Motor Neuron Identity and
Connectivity November 19, 2003 David
Wilkinson (National Institute for Medical Research, Formation and Function of Boundaries in
Hindbrain Patterning December 3, 2003 Gail Martin ( Genetic Analysis of FGF Function in
Mammalian Embryogenesis December 10, 2003 Brigid
Hogan ( Epithelial-Mesenchymal Cell Interactions and
Branching Morphogenesis: The Mouse
Lung as a Model System January 7, 2004 Gary Schoenwolf ( Endoderm as a Source of Patterning
Information for Early Chick Embryogenesis January 14, 2004 Marian Carlson ( Regulation of Snf1/AMPK Kinases and
Responses to Metabolic Stress January 21, 2004 Claudio Stern ( How to Make a Brain: Molecular Dissection of Neural Induction January 28, 2004 Anton Berns (Netherlands Cancer
Institute) Mouse Models for Cancer February 4, 2004 Nahum Sonenberg ( Ribosome Recruitment in Eukaryotes: Regulation of Gene Expression and Cell
Growth February 11, 2004 Sean Carroll ( Molecular Genetics of Animal Evolution February 18, 2004 David Lohnes (Clinical Research Institute of Regulation of Cdx1 by Retinoid and wnt Signaling Pathways BMP Signaling and Adult Stem Cell
Development March 3, 2004 Anne Brunet (Children’s Hospital,
The Forkhead Transcription Factors in the
Control of Apoptosis, Resistance to Stress, and Organismal Longevity March 10, 2004 Alexander Joyner (Skirball Institute,
Howard Hughes Medical Institute) Organizing Centers and Compartments Pattern
the Nervous System March 17, 2004 Elaine Fuchs ( Beauty is Skin Deep: The Biology of the Epidermis and Hair
Follicles March 24, 2004 Bob Kingston ( Functional Analysis of Complexes that
Regulate Chromatin Structure and Transcriptional Memory March 31, 2004 Lee Niswander (Sloan-Kettering
Institute, Howard Hughes Medical Institute) Understanding Vertebrate Limb and Neural
Development Using a Multifaceted Approach April 7, 2004 Haringer Singh (University of Chicago,
Howard Hughes Medical Institute) Transcriptional Regulation of Cell Fates and
Gene Expression in the Immune System April 21, 2004 David Anderson (California Institute of
Technology) Molecular Control of Stem Cell Fate
Determination in the Central and Peripheral Nervous System April 28, 2004 Richard Mann ( The Control of Hox Specificity: New Cofactors Among
Old Friends May 12, 2004 Judith Kimble ( Controls of Germline Stem Cells in C. elegans May 19, 2004 Phil Soriano ( Defining the Signaling Specificity of
Receptor Tyrosine Kinase Signaling May 26, 2004 Jim Smith ( Making Mesoderm in the Frog June 2, 2004 John Reed (Burnham Institute) Apoptosis Mechanisms September 8, 2004 Xiaodong Wang ( September 22,
2004 Frank Costantini ( The Role of GDNF/Ret Signaling in Branching Morphogenesis during Kidney Development September 29,
2004 Robert Lehman ( DNA Replication and Latency in Herpes Viruses October 6,
2004 Tony Gorry ( Information Technology and Behavior October 13,
2004 Virginia Papaioannou ( T-Box Genes in Mouse Development October 20,
2004 Ray Gesteland ( Recoding: Programmed Changes in Decoding October 27,
2004 David Albertini (University of Maternal Governance of Embryogenesis in Mammals: Genetic Models of the Signaling Interface between Germ Line and Soma November 3,
2004 Richard Hanson ( Glyceroneogenesis Revisited November 10,
2004 Roy Jensen (University of Molecular Analysis of Breast Neoplasia November 17,
2004 Tom Gridley (The Jackson Laboratory) Notch Signaling in Mice December 1,
2004 Alan Hinnebusch (National Institutes of
Health) Recruitment and Function of Cofactors in Transcriptional Activation by GCN4 December 8, 2004 Michael Shen ( Regulation of Nodal Signaling in Mouse Embryogenesis January 12,
2005 Cliff Tabin (Harvard Medical School,
Howard Hughes Medical Institute) Signals Patterning the Developing Limb January 19,
2005 John McDonald (Kennedy Krieger
Institute) Repairing the Damaged Cord: From Stem Cell to Activity-based Mechanisms of Recovery February 2,
2005 Larry Simpson ( A Complex Business: Uridine Insertion/Deletion RNA Editing in Trypanosome Mitochondria February 9,
2005 Robin Lovell-Badge (National Institute
for Medical Research) How are the Differences Between Males and Females Initiated During Mammalian Development February 16,
2005 Mark Henkemeyer ( Ephrin Signaling February 23,
2005 Drew Noden ( Head Mesoderm-Neural Crest Interactions: A Story of Victims and Bullies? March 2, 2005 Bruce Hay (California Institute of Technology) Regulating Cell Death and Cell Differentiation in Drosophila March 9, 2005 Tak Mak ( ‘Tis Death That Makes Life Live March 16,
2005 Gary Felsenfeld (National Institutes of
Health) Chromatin Boundaries, Chromatin Domains, and Gene Expression March 23,
2005 Titia de Lange ( Protection and Maintenance of Human Telomeres March 30,
2005 Edwin Rubel ( Developmental Interactions in the Brainstem Auditory Pathways April 6, 2005 Charlie Boone ( Global Mapping of the Yeast Genetic Interaction Network April 13,
2005 John Sedat ( The High Resolution Revolution in Light Microscopy: New Insights into Anaphase Chromosome Structure April 20,
2005 John Yates (Scripps Research Institute) Proteomic Mass Spectrometry April 27,
2005 Betty Hay ( Epithelial-Mesenchymal Transformations: The Signaling Mechanisms that Create Them and the Important Roles They Play in the Embryo May 4, 2005 Bill Smith ( Cyclooxygenases and the Molecular Basis of the Actions of Essential Fatty Acids May 11, 2005 Erin O’Shea ( Analysis of the Budding Yeast Proteome May 18, 2005 Rudolf Jaenisch (Whitehead Institute) Nuclear Cloning, Stem Cells, and Epigenetic Reprogramming September 7,
2005 Manuel Ares ( Global Analysis of Splicing Regulation September 14,
2005 Ralph Greenspan (The Neurosciences
Institute) Sleep, Waking, and Attention in Drosophila September 21,
2005 Daniel Carucci (Foundation for the
National Institutes of Health) Grand Challenges in Global Health September 28,
2005 Wing Hung Wong ( Computational Analysis of Gene Expression and Regulation in ES Cells October 5, 2005 Roberto Dominguez ( Structural Basis of Actin Cytoskeleton Dynamics October 12, 2005 Thomas Pollard ( Control of Actin Filament Dynamics during Cytokinesis and Cellular Motility October 20, 2005 Gary Ruvkun ( Using RNAi to Study Itself October 26, 2005 Ihor Lemischka and Kateri Moore ( Stem Cells and Systems Biology November 2, 2005 Liqun Luo ( Exploring Neural Circuit Organization and Assembly Using Genetic Mosaics in Flies and Mice November 9, 2005 Scott Hawley (Stowers Institute for
Medical Research) How to Hold on to your Partner: Studies of a Simple Meiotic System November 16, 2005 Katherine Jones (The Salk Institute) Transcription Induction Mechanisms in Human Disease: Insights from Wnt, Notch, and HIV-1 Tat November 30, 2005 Kathrin Plath (Whitehead Institute) Function of Polycomb Group Proteins in Mouse Development December 7, 2005 Ardem Patapoutian (Scripps Research
Institute) Molecular Mechanisms of Temperature Sensation December 14, 2005 Gunda Georg ( Drug Discovery in Academia: Opportunities and Challenges Control of Translation and mRNA Degradation in Eukaryotic Cells January 18,
2006 Barbara Graves (Huntsman Cancer
Institute) Routes to Specificity within the ETS Family of Transcription Factors January 25,
2006 Angelika Amon (Massachusetts Institute
of Technology, Howard Hughes Medical Institute) Coordinating Chromosome Segregation February 1,
2006 Deborah Yelon (Skirball Building the Zebrafish Heart: From Progenitor Selection to Chamber Expansion February 8,
2006 Paul Trainor (Stowers Institute for
Medical Research) Craniofacial Development: Unmasking the Origins of Congenital Birth Defects February 15,
2006 Mark Johnston ( Diabetic Yeasts: Glucose Sensing and Signaling by a Eukaryotic Cell February 21,
2006 Roger Kornberg ( Eukaryotic Gene Transcription February 22,
2006 Shelley Berger (The Wistar Institute) Factor and Histone Covalent Modifications in Genome Regulation March 1, 2006 Fred Winston ( Analysis of Factors that Control Transcription and Chromatin Structure in Yeast March 8, 2006 Susan Wente ( Nuclear Import and Export: The Rules and the Players March 15,
2006 Robert Tjian ( Mechanisms of Transcriptional Control and Disease March 29,
2006 Luis Parada ( Modeling Tumors in the Nervous System in Mice April 5, 2006 Thomas Jenuwein (Research Institute of
Molecular Pathology) The Epigenome in the Context of the Post-Genomic Era April 12,
2006 Eric Olson ( Toward a Genetic Blueprint of Cardiovascular Development April 19,
2006 Michael Clarke ( Stem Cell Self-renewal and Cancer April 26,
2006 Jerry Shay ( Aging and Cancer: Are Telomeres and Telomerase the Connection? May 3, 2006 Pam Silver ( Perturbing and Rebuilding Nuclear Networks May 10, 2006 Sally Camper ( Cell Signaling and Transcription Factor Control of Pituitary Cell Fate May 17, 2006 Michael German ( Gene Expression Cascades in Pancreas Development September 6,
2006 Stephen West (Cancer Research Defective DNA Break Repair and Relationship to Human Disease September 13, 2006 Lila Solnica-Krezel (Vanderbilt
University) Genetic Regulation of Gastrulation Movements in Zebrafish September 20,
2006 Mark Winey ( Centrosomes in a Ciliate? The Tetrahymena Basal Body September 27, 2006 Nicole Le Douarin (Académie des
sciences, France) The Neural Crest, a Pluripotent Structure of the Vertebrate Embryo: Developmental and Evolutionary Aspects October 4,
2006 Andrew Emili ( Cracking the (epi)Proteome Code: Adventures in Proteomics October 11,
2006 Phillip Zamore ( RNAi and Other Ancient Pathways Programmed by Small RNAs October 18,
2006 Dan Camerini-Otero (National Institutes
of Health) Meiotic DNA Double-strand Break Repair in Mice and Humans October 25,
2006 Eric Siggia ( Fluctuations and the Cell Cycle in Budding Yeast November 1,
2006 Gerard Grosveld (St. Jude
Children’s MN1, a New Player in Human Acute Myeloid Leukemia November 8,
2006 Robert Murphy ( Location Proteomics: A Systems Biology Approach to Subcellular Location November 15,
2006 Joshua LaBaer ( Functional Proteomics for Biomarker and Target Discovery November 29,
2006 James Hsieh ( Proteolysis of MLL Family Proteins is Essential for Taspase1-orchestrated Cell Cycle Progression December 6, 2006 Ben Barres (Stanford University) How are CNS Synapses Eliminated? December 13,
2006 Christine Thisse ( Patterning the Embryo: From Organizing Centers to Organizing Fields (How to Build an Embryo with Morphogens) January 10,
2007 Hermann Steller (Rockefeller
University, Howard Hughes Medical Institute) Death by Design: Mechanism and Regulation of Apoptosis January 17,
2007 Peter Jackson ( Control
of the Cell Division by Proteolysis and the Primary Cilium January 24,
2007 Barbara Panning ( Non-coding
RNA, Chromatin, and Fate Decisions in Embryonic Stem Cells January 31,
2007 Sharon Dent ( In
vivo Functions of Histone Modifying Enzymes February 7,
2007 Craig Peterson ( Chromatin
Remodeling Machines: Regulators of Transcription and DNA Repair February 14,
2007 Don Hunt ( Identification
of Intact Proteins, Large Peptides, and their Post-translational Modifications
on a Chromatographic
Time-scale by Using a Combination of Ion/Ion Chemistry and Tandem Mass
Spectrometry February 21,
2007 Gordon Keller (University Health
Network, Linage
Specific Differentiation of ES Cells in Culture February 28,
2007 Guillermo Oliver (St. Jude
Children’s Cellular and Molecular Mechanisms Regulating the Development of the Lymphatic Vasculature in Health and Disease March 7, 2007 Christine Field ( Imaging and Biochemistry of Cytokinesis March 12,
2007 Denis Duboule ( Engineering
Chromosomes to Study Large-scale Gene Regulation during Vertebrate Development March 21,
2007 John Lis ( Tracking Transcription Factor Recruitment Dynamics, and Function at Specific Inducible Genes in vivo and in Real Time March 28,
2007 Yigong Shi ( Insights into Programmed Cell Death by Structural Biology April 4, 2007 Joshua Sanes ( Analyzing
Synapse Formation with Mutant and Fluorescent Mice April 11,
2007 Susan Gasser (Friedrich Miescher Institute for Biomedical Research) The Spatial Organization of Repair and Transcription April 18,
2007 Gerard Evan ( Defining Intrinsic Tumor Suppression Pathways in Cancer April 25,
2007 Claude Desplan
( Detection
and Processing of Color Information (in Drosophila) May 2, 2007 Stas Shvartsman ( Quantitative
Analysis of Developmental Signaling Pathways May 9, 2007 Douglas Green (St. Jude
Children’s Apoptosis
and Mitochondria: The Roads to Ruin May 16, 2007 Luis A. Nunes Amaral (Northwestern University) Cartography
Representation of Cellular Processes May 23, 2007 Michael Kastan (St.
Jude Children’s DNA
Damage Responses: Mechanisms and Consequences of Failure May 30, 2007 John Dick ( The Blood and Guts of Cancer Stem Cells September 5,
2007 Louis Ptacek
( Genetic
and Molecular Characterization of the Human Circadian Clock September 12,
2007 Ueli Schibler ( Circadian Gene Expression: Communication between Central and Peripheral Oscillators September 19,
2007 Stephen Johnson ( Growth
Control Mechanisms Revealed by the Zebrafish Fin September 26,
2007 Ali Brivanlou ( Molecular
Basis of Default and Stemness in Human Embryonic Stem
Cells October 3,
2007 Elliot Elson ( Matrix
Metalloproteinase-1 Acts as a Brownian Ratchet October 10,
2007 Weimin Zhong ( Asymmetric Cell Division and Stem Cell Homeostasis October 16,
2007 Andrew Murray ( Studies
on Experimental Evolution in Budding Yeast October 24,
2007 Joe Lutkenhaus
(University of Spatial Regulation of Bacterial Cytokinesis October 31,
2007 Gordon Hager (National Cancer
Institute) Genome-wide Interactions of Nuclear Receptors with Chromatin November 7,
2007 Douglas Robinson ( Dynamic Cortical Rearrangements and Mechanosensing during Cell Division November 14,
2007 Jef Boeke ( Networks
and Pathways of Lysine Modification November 28,
2007 Chunying Du (Stowers Institute for
Medical Research) BRUCE: An Inhibitor of Apoptosis Functions in a Non-apoptosis Pathway December 5,
2007 Christof Niehrs
( Regulation of Wnt Signaling at the Plasma Membrane December 12,
2007 Andrew Fire ( Homology-directed Genetic Surveillance Mechanisms January 9,
2008 David Threadgill
( Elucidation of Pathological Interactions among the Egfr/Erbb Gene Family Using Mouse Models January 16,
2008 Jennifer Gerton (Stowers Institute for
Medical Research) The
Ins and Outs of Chromosome Cohesion January 23,
2008 Ed Munro ( Dynamics of Cell Polarization in the Early C. elegans Embryo January 30,
2008 Richard Harland ( BMP
Antagonists in Vertebrate Development February 6,
2008 Adrian Krainer
( Oncogenic Properties of Alternative Splicing Factors February 13,
2008 Nevan Krogan ( Unbiased
Biology: Functional Insights from
Protein-Protein and Genetic Interaction Datasets February 20,
2008 Orna Cohen-Fix (National Institutes of Health) Shaping
and Misshaping the Nucleus February 27,
2008 David Toczyski
( Cell
Cycle Regulation and the DNA Damage Checkpoint March 5, 2008 David Mangelsdorf ( Feast to Famine: Nuclear Receptor Control of Metabolism March 12,
2008 Trevor Archer (National Institute of
Environmental Health Sciences) Steroid
Receptor Mediated Transcriptional Activation within Chromatin March 19, 2008 Peter Lansdorp ( Non-random
Segmentation of Sister Chromatids March 28,
2008 Blanche Capel
( The
April 2, 2008 George Daley (Children’s Hospital
Boston, Howard Hughes Medical Institute) Customized Pluripotent Stem Cells April 9, 2008 Doug Melton (Harvard University, Howard
Hughes Medical Institute) Pancreatic
Stem Cells for Development and Diabetes April 16,
2008 Kevin Struhl ( How
Proteins Find their Target Sites in vivo:
Implications for Epigenetic Inheritance April 23,
2008 Todd Stukenberg ( Processing Spatial Information in the Mitotic Spindle April 30,
2008 Cori Bargmann ( Assembling
a Circuit for Olfactory Behavior May 7, 2008 Josh Kaplan ( Synaptic Signaling in C. elegans: MicroRNAs and Seizures May 14, 2008 Joe Gall (Carnegie Institution) The
Cell Biology of snRNP Biogenesis May 21, 2008 William Sly ( Evolving Therapeutic Targets for Lysosomal Storage Diseases September 10,
2008 Jodi Nunnari ( The Machines that Divide and Fuse Mitochondria September 17, 2008 Gordon Fishell ( The Developmental Genetic Origins of Cortical Interneurons September 24,
2008 John DiPersio ( Stem Cells and T Cells: Optimizing Allogeneic Stem Cell Transplantation October 1,
2008 David Chao (BioMed Valley Discoveries
& Stowers Institute for Medical Research) Translational R & D at BioMed Valley Discoveries October 8,
2008 Joel Rothman ( Specification and Reprogramming of Germ Layer Identity in C. elegans Embryos October 15,
2008 Philip Benfey
( Getting to the Root of Developmental Networks October 22,
2008 Exploring Mechanisms of Telomere Length Regulation October 29,
2008 Modeling Disease with Human Pluripotent Cells November 5,
2008 Richard Young (Whitehead Institute) Stem Cell Transcriptional Circuitry and Reprogramming November 12,
2008 Fiona Watt (Cancer Research – Stem Cell Renewal and Differentiation in Mammalian Epidermis November 19,
2008 Alan Lambowitz ( Mobile
Group II Introns: Site-specific Integration into DNA and
Applications in Gene Targeting December 2,
2008 Alejandro Sánchez Alvarado
(University of Utah, Howard Hughes Medical Institute) Dying
Young as Late as Possible:
Planarians, Regeneration, and Stem Cells December 10,
2008 Andrea Brand (Wellcome Trust, Cancer
Research Self-renewal and Differentiation in the Drosophila Nervous System January 14,
2009 Sean Eddy (Howard Hughes Medical
Institute) HMMR:
A New Generation of Homology Search Software January 21,
2009 William Kaelin
(Dana-Farber Cancer Institute, Howard Hughes Medical Institute) The
von Hippel-Lindau Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer January 28,
2009 Bruce Bradley (Linda Hall Library) Legacy
of Science: Rare Books in February 4,
2009 Thomas Zwaka ( Embryonic Stem Cells: Building Alternative Pluripotency Networks February 11,
2009 Hugo Bellen ( Growth Cone Guidance Receptors and the Pathogenesis of ALS/Lou Gehrig’s Disease February 18,
2009 Magda Konarska ( Spliceosome Dynamics and Their Impact on the Fidelity of
Splice Site Selection February 25,
2009 David Morgan ( Finishing the Cell Cycle March 4, 2009 Karolin Luger (Colorado State
University, Howard Hughes Medical Institute) Posttranslational Modifications as Regulators of Chromatin Structure and Histone Chaperone Function March 11,
2009 Randy Johnson ( Molecular Genetics of Vertebrate Dorsal-Ventral Limb Patterning March 18,
2009 Bruce Edgar ( Gut Homeostasis Mediated by Drosophila Intestinal Stem Cells March 25,
2009 Michele Calos ( Harnessing Phage Integrases for Gene Therapy and Cell Therapy April 1, 2009 John Rawls ( Host-microbe Relationships in the Zebrafish Digestive Tract April 8, 2009 Ken Zaret ( Connecting Inductive Signals to Epigenetics during Endoderm Differentiation April 15,
2009 Janet Rossant (The Hospital for Sick
Children, Making the Blastocyst: Early Lineage Development in the Mouse April 22,
2009 Leslie Loew (University
of The
Virtual Cell Project April 29,
2009 Bing Ren (Ludwig
Institute for Cancer Research) Chromatin Signatures of Transcriptional Enhancers May 6, 2009 Geoff Rosenfeld ( Life, Death, and Transformation: Repeats, ncRNAs, and Architectural Strategies May 20, 2009 Michael Dyer (St. Jude Children’s
The Role of the Rb Family in Retinal Development and Retinoblastoma September 9,
2009 Irwin Bernstein ( Notch Signaling in Hematopoietic Stem Cells: Basic Findings and Clinical Implications September 16,
2009 Eddy Rubin ( Gene Regulation from a Distance September 23,
2009 Benoit Bruneau (Gladstone Institute of
Cardiovascular Disease) Chromatin Remodeling and the Transcriptional Regulation of Heart Development September 30,
2009 Fred Chang ( Shaping the Fission Yeast Cell October 7,
2009 Russell DeBose-Boyd ( Cholesterol Homeostasis and Sterol-accelerated Degradation of HMG CoA Reductase October 14,
2009 Aseem Ansari ( Exploring Gene Regulation through Chemistry and Genomics October 21,
2009 Steven McKnight ( Mouse Embryonic Stem Cells Exist in a Unique, Threonine-dependent Metabolic State October 28,
2009 Elaine Fuchs (Rockefeller University,
Howard Hughes Medical Institute) Skin Stem Cells in Morphogenesis and Cancer November 4,
2009 Neil Kelleher ( Viewing the Chromatin of Dying Cells through the Lens of Top-Down Mass Spectrometry November 11, 2009 Mark Hochstrasser (Yale University) Cellular Construction of a Protein Machine: Chaperone-assisted Proteasome Assembly November 18,
2009 James Nelson ( Cross-talk between Cell Adhesion Complexes in the Control of Morphogenetic Cell Movements December 2,
2009 Oliver Hobert (Columbia University,
Howard Hughes Medical Institute) Gene
Regulatory Mechanisms Controlling Left/Right Asymmetry in the Nervous System of
C. elegans December 9,
2009 Bradley Bernstein ( Epigenomic Studies of Normal and Malignant Stem Cells |
