Stowers News

The Yin and Yang of stem cell quiescence and proliferation

Jul 19 2012

Non-canonical Wnt-signaling maintains a quiescent pool of blood-forming stem cells in mouse bone marrow

KANSAS CITY, MO—Not all adult stem cells are created equal. Some are busy regenerating worn out or damaged tissues, while their quieter brethren serve as a strategic back-up crew that only steps in when demand shoots up. Now, researchers at the Stowers Institute for Medical Research have identified an important molecular cue that keeps quiescent mouse hematopoietic (or blood-forming) stem cells from proliferating when their services are not needed.

Stowers Institute launches Original Data Repository

Jul 13 2012

The Stowers Institute for Medical Research announces the public launch of the Stowers Original Data Repository (ODR). As a strong supporter of the scientific ideals of transparency and openness, the Stowers Institute believes that the data underlying its published work should be freely accessible to the scientific community.

Forty’s a crowd

Jun 29 2012

“Paper of the week” shows that a master regulator protein brings plethora of coactivators to gene expression sites

KANSAS CITY, MO—Molecular geneticists call big boss proteins that switch on broad developmental or metabolic programs “master regulators,” as in master regulators of muscle development or fat metabolism. One such factor, the Activating Transcription Factor 6α (ATF6α) protein, takes charge following a cellular crisis known as endoplasmic reticulum (ER) stress, which is triggered by the accumulation of misfolded and aggregated proteins.

Next generation of outstanding researchers recognized through prestigious fellowships and awards

Jun 14 2012

KANSAS CITY, MO—Three successful young Stowers scientists have been named the recipients of highly competitive awards, including a research fellowship from American Cancer Society research fellowship, a prize by the Portuguese Foundation for Science and Technology for an outstanding doctoral thesis in molecular medicine and a DeLill Nasser Award for Professional Development.
 

Pinched off

Jun 11 2012

An actin-ratchet tightens the contractile ring that severs budding daughter cells from their yeast mothers

Stowers scientist Julia Zeitlinger awarded 2012 Hudson Prize

May 23 2012

Kansas City, MO—Dr. Julia Zeitlinger, a Stowers Institute assistant investigator, has been named the recipient of the 2011 Hudson Prize by the M.R. and Evelyn Hudson Foundation.

Through the Hudson Prize, the Texas-based M.R. and Evelyn Hudson Foundation encourages early career scientists to pursue research that leads to important medical breakthroughs and treatments.

Control of gene expression: histone occupancy in your genome

May 1 2012

A team of Stowers scientists defines biochemical crosstalk between DNA interacting proteins and their modifications

KANSAS CITY, MO—When stretched out, the genome of a single human cell can reach six feet. To package it all into a tiny nucleus, the DNA strand is tightly wrapped around a core of histone proteins in repeating units—each unit known as a nucleosome. To allow access for the gene expression machinery the nucleosomes must open up and regroup when the process is complete. 

Jarid2 may break the Polycomb silence

Apr 30 2012

Stowers scientists use fruit flies to reveal unknown function of a transcriptional regulator of development and cancer

KANSAS CITY, MO—Historically, fly and human Polycomb proteins were considered textbook exemplars of transcriptional repressors, or proteins that silence the process by which DNA gives rise to new proteins. Now, work by a team of researchers at the Stowers Institute for Medical Research challenges that dogma.

On the Move

Apr 9 2012

KANSAS CITY, MO—Cells on the move reach forward with lamellipodia and filopodia, cytoplasmic sheets and rods supported by branched networks or tight bundles of actin filaments. Cells without functional lamellipodia are still highly motile but lose their ability to stay on track, report researchers at the Stowers Institute for Medical Research in the April 9, 2012, online issue of the Journal of Cell Biology.

Stowers Institute ranks among the top 10 places for postdocs nationwide

Mar 29 2012

KANSAS CITY, MO—The Stowers Institute for Medical Research was ranked among the top 10 U.S. institutions listed as “Best Places to Work: Postdocs,” The Scientist announced today.

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