Theophilus Tettey

Conaway lab

Eukaryotic protein coding genes are transcribed by RNA polymerase II (Pol II) into pre-mRNAs, which are capped at their 5’ ends and polyadenylated at their 3’ ends. The nascent RNAs are also processed by RNA splicing, in which intervening sequences, or introns, are removed, and the remaining portions of the transcripts, or exons, are ligated together to form the mature mRNA. There is evidence that most splicing events occur co-transcriptionally. The goal of my research is to understand how certain protein factors that regulate transcription influence RNA processing events.