Core Centers

Research support services

An important cornerstone of the Stowers Institute’s philosophy is to provide a first-rate scientific infrastructure and easy access to the latest technology. Each core is headed by an expert in the field committed to the development, implementation and optimization of cutting-edge methodologies and instrumentation for the benefit of research programs at the institute. The small size of the institute’s research community allows the more than 100 highly trained scientists working in the research support cores to collaborate closely with Stowers investigators and to quickly adjust technical applications and support services to the requirements of individual labs. This not only promotes interdisciplinary research but also enables investigators to take advantage of the readily available expertise to expand their own research into new areas. What would take months and years elsewhere is often accomplished within days and weeks at the Stowers Institute.



Automation and PCR Technology

The Automation and PCR Technology Team is dedicated to successful, high-quality project collaborations and assist Institute research by supporting the use of numerous state-of-the-art instruments to enable completion of high-throughput projects and screens.



Computational Biology

The Computational Biology Facility provides service, training, collaborations and the development of new applications in the areas of sequence analysis, expression/ChIP analysis, general statistical and numerical analysis and support for scientific software and databases.



The Cytometry Center is a state-of-the-art flow cytometry laboratory that specializes in the identification and isolation of rare target cell populations and the use of cytometric tools for studies of developmental biology.


Electron Microscopy

The Electron Microscopy Facility assists with sample fixation and preparation for routine histology and ultra-structural analysis.



Genome Engineering

The Genome Engineering Team supports the CRISPR-Cas genome engineering technology and provides a variety of services including guideRNA design and assembly, donor construct design and assembly, preparation of reagents for injection or electroporation, and mutation detection by pooled amplicon sequencing.



The Histology Facility offers expert service for the detection of gene and protein expression in tissue samples and performs histochemical staining. 



The Imaging Facility specializes in the development and application of innovative imaging tools including tools such as multicolor cell labeling and multispectral imaging strategies, photo-activatable fluorescent reporters and calcium indicators, deep tissue embryo imaging as well as laser capture microdissection and gene expression analysis.


Laboratory Animal Services

The Laboratory Animal Services (LAS) Facility provides the institute’s research staff with the highest quality laboratory animal care and support services using the most sophisticated equipment, advanced technology, and a progressive staff in a premier animal facility.


Media Preparation

The Media Preparation Facility prepares commonly used solutions and media, while the Tissue Culture Laboratory grows widely used cell lines and can maintain, expand and store specific cell lines as requested.



The Microscopy Facility focuses on light as a tool for imaging and measuring biological systems. It uses and develops software for image processing and data analysis.



The Proteomics Center implements a chromatography-based proteomic approach known as multidimensional protein identification (MudPIT) combined with spectral counting for label-free proteomics quantitation. It analyzes affinity-purified protein complexes or subcellular fractions, while more in-depth analyses can be undertaken to find post-translational modifications in proteins of interest or to derive large scale protein interaction networks.

Reptile & Aquatics

The Reptile & Aquatics Facility provides the institute’s research staff with the highest quality  animal husbandry and technical services for non-mammalian species. Lizards, zebrafish, planaria and sea anemones are currently housed.



The Screening Facility provides cutting-edge technologies and robotics to perform automated high-throughput screening of genomic and compound libraries. These platforms can be assayed using a multitude of endpoints including high-content imaging, fluorescence, time-resolve fluorescence, luminescence, absorbance and alphascreen.

Sequencing and Discovery Genomics

The Sequencing and Discovery Genomics Team enables genomics research with rapid high-throughput, short-read sequencing using the Illumina Next Generation Sequencing platforms, facilitates projects requiring long-reads through trusted external partners, and performs high-throughput plasmid preparation and Sanger sequencing.

Tissue Culture

The Tissue Culture Core Laboratory comprises a group of experienced cell culture specialists who are dedicated to supporting the research staff in their tissue culture needs. The Facility provides mycoplasma testing, cell banking, transfection services (stable cell line production) and large-scale cell expansion for Stowers researchers.