Skip to main content



Supporting the scientific spirit of transparency, the Stowers Institute for Medical Research makes the data underlying its scientific publications freely accessible to the scientific community. Access to original, unprocessed data allows other scientists to validate and extend findings made by Stowers researchers.


Display results from:

Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis.

Lee G, Goretsky T, Managlia E, Dirisina R, Singh AP, Brown JB, May R, Yang GY, Ragheb JW, Evers BM, Weber CR, Turner JR, He XC, Katzman RB, Li L, Barrett TA. Gastroenterology. 2010;139:869-881, 881 e861-869.

Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis.

Brown JB, Lee G, Managlia E, Grimm GR, Dirisina R, Goretsky T, Cheresh P, Blatner NR, Khazaie K, Yang GY, Li L, Barrett TA. Gastroenterology. 2010;138:595-605, 605 e591-593.

Two-photon microscopy and spectral detection for ex vivo imaging of individual stem cells

Wiegraebe W, Xie Y, Yin T, Stark D, Perko K, Alexander R, Schwartz J, He XC, Li L. Nat Protoc in Protoc Ntwk. 2009 doi:10.1038/nprot.2009.1048.

Detection of functional haematopoietic stem cell niche using real-time imaging

Xie Y, Yin T, Wiegraebe W, He XC, Miller D, Stark D, Perko K, Alexander R, Schwartz J, Grindley JC, Park J, Haug JS, Wunderlich JP, Li H, Zhang S, Johnson T, Feldman RA, Li L. Nature. 2009;457:97-101.

N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells

Haug JS, He XC, Grindley JC, Wunderlich JP, Gaudenz K, Ross JT, Paulson A, Wagner KP, Xie Y, Zhu R, Yin T, Perry JM, Hembree MJ, Redenbaugh EP, Radice GL, Seidel C, Li L. Cell Stem Cell.2008;2:367-379.

Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice

Bleuming SA, He XC, Kodach LL, Hardwick JC, Koopman FA, Ten Kate FJ, van Deventer SJ, Hommes DW, Peppelenbosch MP, Offerhaus GJ, Li L, van den Brink GR. Cancer Res.2007;67:8149-8155.

PTEN-deficient intestinal stem cells initiate intestinal polyposis

He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L. Nat Genet.2007;39:189-198.

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, Haug JS, Rupp D, Porter-Westpfahl KS, Wiedemann LM, Wu H, Li L. Nature. 2006;441:518-522.

Sterile and disposable fluidic subsystem suitable for clinical high speed fluorescence-activated cell sorting

Jayasinghe SM, Wunderlich J, McKee A, Newkirk H, Pope S, Zhang J, Staehling-Hampton K, Li L, Haug JS. Cytometry B Clin Cytom.2006;70:344-354.

Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion

Zhang J, He XC, Tong WG, Johnson T, Wiedemann LM, Mishina Y, Feng JQ, Li L. Stem Cells.2006;24:2826-2839.

Cre-mediated site-specific recombination in zebrafish embryos

Thummel R, Burket CT, Brewer JL, Sarras MP, Jr., Li L, Perry M, McDermott JP, Sauer B, Hyde DR, Godwin AR. Dev Dyn.2005;233:1366-1377.

BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling

He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, Mishina Y, Li L. Nat Genet.2004;36:1117-1121.

Proteomic analysis identifies that 14-3-3{zeta} interacts with {beta}-catenin and facilitates its activation by Akt

Tian Q, Feetham MC, Tao WA, He XC, Li L, Aebersold R, Hood L. Proc Natl Acad Sci U S A.2004.

Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis

AkashiK, He X, Chen J, Iwasaki H, Niu C, Steenhard B, Zhang J, Haug J, Li L. Blood. 2003;101:383-389.

Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischemia-reperfusion injury in mice

Lin F, Cordes K, Li L, Hood L, Couser WG, Shankland SJ, Igarashi P. J Am Soc Nephrol. 2003;14:1188-1199.

Activated Notch4 Inhibits Angiogenesis: Role of beta1-Integrin Activation

Leong KG, Hu X, Li L, Noseda M, Larrivee B, Hull C, Hood L, Wong F, Karsan A. Mol Cell Biol. 2002;22:2830-2841.

Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis

Ning XH, Chen SH, Xu CS, Li L, Yao LY, Qian K, Krueger JJ, Hyyti OM, Portman MA. J Appl Physiol. 2002;92:2200-2207.

Differential gene expression profiling of adult murine hematopoietic stem cells

Park IK, He Y, Lin F, Laerum OD, Tian Q, Bumgarner R, Klug CA, Li K, Kuhr C, Doyle MJ, Xie T, Schummer M, Sun Y, Goldsmith A, Clarke MF, Weissman IL, Hood L, Li L. Blood. 2002;99:488-498.

Page 4 of 4

Unraveling the molecular components and genetic blueprints of stem cells

Li L, Akashi K. BioTechniques. 2003;35:1233-1239.

Q & A

Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, Haug JS, Rupp D, Porter-Westpfahl KS, Wiedemann LM, Wu H, Li L. Nature.2006;441:519-522.

Identification of the haematopoietic stem cell niche and control of the niche size

Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, Ross J, Haug J, Johnson T, Feng JQ, Harri S, Wiedemann LM, Mishina Y, Li L. Nature. 2003;425:836-841

Page 4 of 4

Newsletter & Alerts