Publications
Publications
Supporting the scientific spirit of transparency, the Stowers Institute for Medical Research makes the data underlying its scientific publications freely accessible to the scientific community. Access to original, unprocessed data allows other scientists to validate and extend findings made by Stowers researchers.
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Nascent mitochondrial proteins initiate the localized condensation of cytosolic protein aggregates on the mitochondrial surface
Liu Q, Fong B, Yoo S, Unruh JR, Guo F, Yu Z, Chen J, Si K, Li R, Zhou C. Proc Natl Acad Sci U S A. 2023;120:e2300475120.
Proteome plasticity in response to persistent environmental change
Domnauer M, Zheng F, Li L, Zhang Y, Chang CE, Unruh JR, Conkright-Fincham J, McCroskey S, Florens L, Zhang Y, Seidel C, Fong B, Schilling B, Sharma R, Ramanathan A, Si K, Zhou C. Mol Cell. 2021;81:3294-3309 e3212.
A six-amino-acid motif is a major determinant in functional evolution of HOX1 proteins
Singh NP, De Kumar B, Paulson A, Parrish ME, Zhang Y, Florens L, Conaway JW, Si K, Krumlauf R. Genes Dev. 2020;34:1680-1696.
Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila.
Hervas R, Rau MJ, Park Y, Zhang W, Murzin AG, Fitzpatrick JAJ, Scheres SHW, Si K. Science. 2020;367:1230-1234.
Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo
Nil Z, Millan RH, Gerbich T, Leal P, Yu Z, Saraf A, Sardiu M, Lange JJ, Yi K, Unruh J, Slaughter B, Si K. Cell. 2019;178:1403-1420 e1421.
Antimicrobial peptides modulate long-term memory
Barajas-Azpeleta R, Wu J, Gill J, Welte R, Seidel C, McKinney S, Dissel S, Si K. PLoS Genet. 2018;14:e1007440. doi: 1007410.1001371/journal.pgen.1007440.
Regulated Intron Removal Integrates Motivational State and Experience
Gill J, Park Y, McGinnis JP, Perez-Sanchez C, Blanchette M, Si K. Cell.2017;169:836-848.e815.
Immediate perception of a reward is distinct from the reward's long-term salience
McGinnis JP, Jiang H, Agha MA, Perez Sanchez C, Lange JJ, Yu Z, Marion-Poll F, Si K. eLife.2016;5:e22283. doi: 22210.27554/eLife.22283.
A Putative Biochemical Engram of Long-Term Memory
Li L, Sanchez CP, Slaughter BD, Zhao Y, Khan MR, Unruh JR, Rubinstein B, Si K. Curr Biol.2016;26:3143-3156.
ApCPEB4, a non-prion domain containing homolog of ApCPEB, is involved in the initiation of long-term facilitation
Lee SH, Shim J, Cheong YH, Choi SL, Jun YW, Lee SH, Chae YS, Han JH, Lee YS, Lee JA, Lim CS, Si K, Kassabov S, Antonov I, Kandel ER, Kaang BK, Jang DJ. Mol Brain.2016;9:91.
Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation.
Hervas R, Li L, Majumdar A, Fernandez-Ramirez MD, Unruh JR, Slaughter BD, Galera-Prat A, Santana E, Suzuki M, Nagai Y, Bruix M, Casas-Tinto S, Menendez M, Laurents DV, Si K, Carrion-Vazquez M. PLoS Biol.2016;14:e1002361. doi: 10.1371/journal.pbio.1002361.
Amyloidogenic Oligomerization Transforms Drosophila Orb2 from a Translation Repressor to an Activator.
Khan MR, Li L, Perez-Sanchez C, Saraf A, Florens L, Slaughter BD, Unruh JR, Si K. Cell. 2015;163:1468-1483.
Contribution of Orb2A Stability in Regulated Amyloid-Like Oligomerization of Drosophila Orb2.
White-Grindley E, Li L, Mohammad Khan R, Ren F, Saraf A, Florens L, Si K. PLoS Biol. 2014;12:e1001786.
Analysis of the African coelacanth genome sheds light on tetrapod evolution
Amemiya CT, Alföldi J, Lee AP, Fan S, Philippe H, Maccallum I, Braasch I, Manousaki T, Schneider I, Rohner N, Organ C, Chalopin D, Smith JJ, Robinson M, Dorrington RA, Gerdol M, Aken B, Biscotti MA, Barucca M, Baurain D, Berlin AM, Blatch GL, Buonocore F, Burmester T, Campbell MS, Canapa A, Cannon JP, Christoffels A, De Moro G, Edkins AL, Fan L, Fausto AM, Feiner N, Forconi M, Gamieldien J, Gnerre S, Gnirke A, Goldstone JV, Haerty W, Hahn ME, Hesse U, Hoffmann S, Johnson J, Karchner SI, Kuraku S, Lara M, Levin JZ, Litman GW, Mauceli E, Miyake T, Mueller MG, Nelson DR, Nitsche A, Olmo E, Ota T, Pallavicini A, Panji S, Picone B, Ponting CP, Prohaska SJ, Przybylski D, Saha NR, Ravi V, Ribeiro FJ, Sauka-Spengler T, Scapigliati G, Searle SM, Sharpe T, Simakov O, Stadler PF, Stegeman JJ, Sumiyama K, Tabbaa D, Tafer H, Turner-Maier J, van Heusden P, White S, Williams L, Yandell M, Brinkmann H, Volff JN, Tabin CJ, Shubin N, Schartl M, Jaffe DB, Postlethwait JH, Venkatesh B, Di Palma F, Lander ES, Meyer A, Lindblad-Toh K. Nature. 2013 Apr 18;496(7445):311-6.
Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory.
Majumdar A, Cesario WC, White-Grindley E, Jiang H, Ren F, Khan MR, Li L, Choi EM, Kannan K, Guo F, Unruh J, Slaughter B, Si K. Cell. 2012;148:515-529.
Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover.
Mastushita-Sakai T, White-Grindley E, Samuelson J, Seidel C, Si K. Proc Natl Acad Sci U S A. 2010;107:11987-11992.
Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation.
Si K, Choi YB, White-Grindley E, Majumdar A, Kandel ER. Cell.2010;140:421-435.
Implications of the Orb2 Amyloid Structure in Huntington’s Disease
Hervas R, Murzin AG, Si K. Int J Mol Sci. 2020;21:E6910. doi: 6910.3390/ijms21186910.
When mothers leave their mark
Barajas-Azpeleta R, Si K. eLife. 2019;8:e48899. doi: 48810.47554/eLife.48899.
Translational Control by Prion-like Proteins
Li L, McGinnis JP, Si K. Trends Cell Biol.2018;28:494-505.
The Role of Functional Prion-Like Proteins in the Persistence of Memory
Si K, Kandel ER. Cold Spring Harb Perspect Biol. 2016;8:a021774. doi: 021710.021101/cshperspect.a021774.
Prions: What Are They Good For?
Si K. Annu Rev Cell Dev Biol. 2015;31:149-169.
RISC-y Memories
White-Grindley E, Si K. Cell.2006;124:23-26.
