Publications
Publications
Supporting the scientific spirit of transparency, the Stowers Institute for Medical Research makes the data underlying its scientific publications freely accessible to the scientific community. Access to original, unprocessed data allows other scientists to validate and extend findings made by Stowers researchers.
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Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal
Kandola T, Venkatesan S, Zhang J, Lerbakken B, Schulze AV, Blanck JF, Wu J, Unruh J, Berry P, Lange JJ, Box A, Cook M, Sagui C, Halfmann R. eLife 2023;12:RP86939. doi: 10.7554/eLife.86939.
DAmFRET measures saturating concentrations and toxicities of protein phase transitions in vivo
Miller T, Wu J, Venkatesan S, Gama AR, Halfmann R. Mol Biol Cell. 2023:mbcE22110503.
A nucleation barrier spring-loads the CBM signalosome for binary activation
Rodriguez Gama A, Miller T, Lange JJ, Unruh JR, Halfmann R. eLife. 2022;11:e79826. doi: 10.7554/eLife.79826.
DNCON2_Inter: predicting interchain contacts for homodimeric and homomultimeric protein complexes using multiple sequence alignments of monomers and deep learning
Quadir F, Roy RS, Halfmann R, Cheng J. Sci Rep. 2021;11:12295. doi 10.1038/s41598-021-91827-7.
Mechanistic inferences from analysis of measurements of protein phase transitions in live cells
Posey AE, Ruff KM, Lalmansingh JM, Kandola TS, Lange JJ, Halfmann R, Pappu RV. [published ahead of print February 5 2021]. J Mol Biol. 2021:166848. doi: 166810.161016/j.jmb.162021.166848.
wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death
Nuckolls NL, Mok AC, Lange JJ, Yi K, Kandola TS, Hunn AM, McCroskey S, Snyder JL, Bravo Nunez MA, McClain M, McKinney SA, Wood C, Halfmann R, Zanders SE. eLife. 2020;9:e55694. doi: 55610.57554/eLife.55694.
Detecting and Characterizing Protein Self-Assembly in vivo by Flow Cytometry
Venkatesan S, Kandola TS, Rodriguez-Gama A, Box A, Halfmann R. J Vis Exp. 2019;149:e59577. doi: 59510.53791/59577.
Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation
Holliday MJ, Witt A, Rodriguez Gama A, Walters BT, Arthur CP, Halfmann R, Rohou A, Dueber EC, Fairbrother WJ. Nat Commun. 2019;10:3070. doi: 10.1038/s41467-019-10953-z.
Quantifying nucleation in vivo reveals the physical basis of prion-like phase behavior
Khan T, Kandola TS, Wu J, Venkatesan S, Ketter E, Lange JJ, Rodriguez Gama A, Box A, Unruh JR, Cook M, Halfmann R. Mol Cell.2018;71:155-168.e157.
A self-perpetuating repressive state of a viral replication protein blocks superinfection by the same virus
Zhang XF, Sun R, Guo Q, Zhang S, Meulia T, Halfmann R, Li D, Qu F. PLoS Pathog.2017;13:e1006253. doi: 1006210.1001371/journal.ppat.1006253.
Single-Cell Based Quantitative Assay of Chromosome Transmission Fidelity.
Zhu J, Heinecke D, Mulla W, Bradford WD, Rubinstein B, Box A, Haug JS, Li R. G3 (Bethesda). 2015.;5:1043-56.
Heparan Sulfate Proteoglycans Regulate Fgf Signaling and Cell Polarity during Collective Cell Migration.
Venero Galanternik M, Kramer KL, Piotrowski T. Cell Rep. 2015;10:414-428.
The 2021 FASEB Virtual Science Research Conference on Protein Aggregation: Function, Dysfunction, and Disease, June 23-25, 2021
Hatters DM, Halfmann R, Baum J. T. FASEB J. 2021;35:e21884.
Mechanics of a molecular mousetrap-- nucleation-limited innate immune signaling
Rodriguez Gama A, Miller T, Halfmann R. Biophys J. 2021;120:1150-1160..
A glass menagerie of low complexity sequences
Halfmann R. Curr Opin Struct Biol. 2016;38:9-16.
