Ron Conaway, PhD
Investigator
Professor, Department of Biochemistry and Molecular Biology, University of Kansas School of Medicine

AB, Physics and Chemistry, Indiana University-Bloomington
PhD, Biochemistry, Stanford University School of Medicine

Areas of Interest 
Chromatin, Gene Expression Regulation
Profile 

Ron Conaway, PhD, is a member of one of science's most accomplished research teams, "The Conaways," known for uncovering many of the mechanisms that underlie gene transcription. He and his wife Joan were among the first researchers to join the Stowers Institute and have been an integral part of its growth and success.

Raised in Montana, Ron earned a bachelor’s degree in physics and chemistry from Indiana University and fell only one course short of adding a degree in philosophy as well. He and Joan married while graduate students at Stanford. The couple started working together when Ron, having earned a PhD in the early 80s in the lab of I. Robert Lehman, PhD, at Stanford, was working on his postdoctoral studies at the DNAX Research Institute in Palo Alto, and Joan was a graduate student in Roger Kornberg’s lab at Stanford. Kornberg, who would receive the 2006 Nobel Prize in Chemistry for his pioneering studies on gene transcription, encouraged the two talented young scientists to join forces to tackle what was then a scientific mystery: the identity of the molecular factors that launch the transcription process. Ron and Joan have been together — both in research and in life — ever since. In 1989, the Conaways took faculty positions at the Oklahoma Medical Research Foundation. They joined the Stowers Institute in 2001.

From their early days working long hours together in the lab at Stanford, the Conaways have approached their research as a team. The couple has made a conscious effort to share both responsibility and credit, taking turns on being senior author when publishing papers.

In their spare time, Ron and Joan enjoy listening to live jazz music, eating out in restaurants, and hanging out at home.

Research Summary 

The Conaway Lab investigates the mechanisms that underlie gene transcription—the process that copies the information in DNA into a new molecule of messenger RNA. In addition to revealing how gene transcription occurs at the molecular level, the Conaways' research has highlighted some of the steps in the process that may play a role in cancer and other diseases.

The human genome contains about 25,000 genes with the instructions for building all the proteins in the body. But before construction of any protein can begin, the genetic information contained within the DNA must first be copied into RNA by the cell’s transcription machinery. Critical steps in this process include initiation, when the enzyme RNA polymerase II finds the beginning of a gene and starts to copy it, and elongation, the stage when the RNA strand lengthens. Over their careers, the Conaways have produced a body of work that helps to explain how transcription of messenger RNA is regulated. They defined several of the key transcription factors needed for initiation and were the first to reproduce transcription initiation by RNA polymerase II in the test tube with pure proteins. In addition, they identified transcription elongation factors Elongin and ELL. Many of their discoveries have focused on Elongin, a molecule that plays two roles in transcription — acting as a facilitator by restarting transcription machinery when it sputters or a destroyer by marking the transcription machinery to be decommissioned when it is stalled – while others centered around understanding how a very large protein complex called the Mediator coordinates the activities of ELL and other transcription factors during initiation and elongation. Their studies on these molecules could give insight into diseases that result from the process going awry.

In recognition of their achievements Joan was an Associate Investigator of the Howard Hughes Medical Institute between 1997 and 2001. Both Ron and Joan received the American Society for Biochemistry and Molecular Biology/Amgen Award in 1997 and were elected in 2002 to the American Academy of Arts and Sciences. She was elected to the National Academy of Sciences in 2020.

Featured Publications 
Takahashi H, Ranjan A, Chen S, Suzuki H, Shibata M, Hirose T, Hirose H, Sasaki K, Abe R, Chen K, He Y, Zhang Y, Takigawa I, Tsukiyama T, Watanabe M, Fujii S, Iida M, Yamamoto J, Yamaguchi Y, Suzuki Y, Matsumoto M, Nakayama KI, Washburn MP, Saraf A, Florens L, Sato S, Tomomori-Sato C, Conaway RC, Conaway JW, Hatakeyama S. Nat Commun. 2020;11:1063. doi: 10.1038/s41467-020-14849-1.
Weems JC, Slaughter BD, Unruh JR, Boeing S, Hall SM, McLaird MB, Yasukawa T, Aso T, Svejstrup JQ, Conaway JW, Conaway RC. J Biol Chem.2017;292:6431-6437.
Tsai KL, Tomomori-Sato C, Sato S, Conaway RC, Conaway JW, Asturias FJ. Cell.2014;157:1430-1444.
Sela D, Conkright JJ, Chen L, Gilmore J, Washburn MP, Florens L, Conaway RC, Conaway JW. J Biol Chem. 2013;288:26179-26187.
Takahashi, H., Parmely, T.J., Sato, S., Tomomori-Sato, C., Banks, C.A., Kong, S.E., Szutorisz, H., Swanson, S.K., Martin-Brown, S., Washburn, M.P., Florens, L., Seidel, C., Lin, C., Smith, E.R., Shilatifard, A., Conaway, R.C., Conaway, J.W. (2011) Cell 146, 92-104.
Conaway RC, Conaway JW. Curr Opin Genet Dev.2011;21:225-230.
Honors

2002
Member, American Academy of Arts and Sciences

1997
ASBMB-Amgen Award

1991
Edward L. and Thelma Gaylord Award for Scientific Excellence

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