Associate Investigator Matt Gibson Receives NIGMS Grant
Associate Investigator Matt Gibson, PhD, has received a grant from the National Institute of General Medical Sciences, a division within the National Institutes of Health. The competitive grant will fund a project designed to expand the fundamental knowledge of an unexplored area of basic biology.
During development of multicellular animals, layer upon layer of epithelial cells provide the architectural structure for nearly all organ shapes and functions. However, not much is known about cell division within this epithelial architecture.
In humans, a majority of metastatic cancers originate from epithelial cells that divide excessively and escape their normal confines. This process is called epithelial-tomesenchymal transition (EMT). Gibson’s proposal includes using genetic, biochemical and proteomic analysis of fruit flies to study the molecular mechanisms that coordinate cell division in healthy epithelia and how defects in these mechanisms can result in EMT.