Laboratory Animal Services

The Laboratory Animal Services Facility team supports Stowers research programs that include the study of animal models to better understand biological processes of health and disease.

Research Services 

The Laboratory Animal Services Facility (LASF) provides the Institute’s research staff with AAALAC-accredited laboratory animal care and support services using state-of-the-art equipment, advanced technology, and a progressive staff in a premier animal facility. The LASF is responsible for maintaining the health and welfare of all mammalian species involved in research studies at the Institute, predominantly mice and rats.

The facility is designed to maintain animal projects under rigorous barrier conditions with every effort made to limit the introduction of undesirable pathogens that may impact the integrity and reproducibility of the research data. High standards of animal health and welfare are maintained, regularly monitored, and examined by federal agencies and local ethics committees.

The LASF provides services in a wide range of invasive and non-invasive procedures including injections, embryo harvests, blood and tissue collection, surgeries, and the creation of genetically modified mouse models using microinjection techniques.

Technology 
  • Steris Detach® Robotics
  • Vevo 2100 Ultrasound Imaging System
  • CUY21EDIT-II Square Wave Electroporator
  • GC-40 Cesium Irradiator
  • Edstrom Watchdog Monitoring System
Team Contact 
Featured Publications 
Kushawah G, Hernandez-Huertas L, Abugattas-Nunez Del Prado J, Martinez-Morales JR, DeVore ML, Hassan H, Moreno-Sanchez I, Tomas-Gallardo L, Diaz-Moscoso A, Monges DE, Guelfo JR, Theune WC, Brannan EO, Wang W, Corbin TJ, Moran AM, Sanchez Alvarado A, Malaga-Trillo E, Takacs CM, Bazzini AA, Moreno-Mateos MA. [published ahead of print August 10 2020]. Dev Cell. 2020
Zhao M, Tao F, Venkatraman A, Li Z, Smith SE, Unruh J, Chen S, Ward C, Qian P, Perry JM, Marshall H, Wang J, He XC, Li L. Cell Rep. 2019;26:652-669 e656
Qian P, De Kumar B, He XC, Nolte C, Gogol M, Ahn Y, Chen S, Li Z, Xu H, Perry JM, Hu D, Tao F, Zhao M, Han Y, Hall K, Peak A, Paulson A, Zhao C, Venkatraman A, Box A, Perera A, Haug JS, Parmely T, Li H, Krumlauf R, Li L. Cell Stem Cell. 2018;22:740-754 e747
Li Z, Qian P, Shao W, Shi H, He XC, Gogol M, Yu Z, Wang Y, Qi M, Zhu Y, Perry JM, Zhang K, Tao F, Zhou K, Hu D, Han Y, Zhao C, Alexander R, Xu H, Chen S, Peak A, Hall K, Peterson M, Perera A, Haug JS, Parmely T, Li H, Shen B, Zeitlinger J, He C, Li L. Cell Res. 2018. Author Correction: Cell Res 2018:1-14. https://doi.org/10.1038/s41422-018-0072-0. Published online July 2018.;28:904-917
Kurosaka H, Wang Q, Sandell L, Yamashiro T, Trainor PA. Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia. Hum Mol Genet. 2017;26:1268-1279
Aoto K, Sandell LL, Butler Tjaden NE, Yuen KC, Watt KE, Black BL, Durnin M, Trainor PA. Dev Biol. 2015;402:3-16
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