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Lola-I is a promoter pioneer factor that establishes de novo Pol II pausing during development.

Ramalingam V, Yu X, Slaughter BD, Unruh JR, Brennan KJ, Onyshchenko A, Lange JJ, Natarajan M, Buck M, Zeitlinger J. Nat Commun. 2023;14:5862 doi: 10.1038/s41467-023-41408-1.

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Publication Notes

The Stowers Institute contributing authors have selected to present the raw data of this manuscript resulting from work performed at The Stowers Institute.  Raw and processed functional genomics data associated with this manuscript have been deposited in GEO under accession number, “GSE200875. And part of the wild-type functional genomics data is available from the previously released GEO dataset, GSE120157. Source data for the graphs are provided with this paper. The nucleosome model figure uses the nucleosome structure from the RCSB PDB database. The raw and processed data are also available through a publicly accessible Amazon Linux virtual machine image 33 (ami-id: ami-08731b3f99f24143f), and the unprocessed microscopy and western blot images are available through the Stowers Institute’s original data repository. All data analysis performed in this paper, including raw data, processed data, software tools, and analysis scripts are available through a publicly accessible Amazon Linux virtual machine image (ami-id: ami-08731b3f99f24143f). The analysis code is also available on GitHub. The analysis code is also available on Zonedo (Ramalingam et al., 2023).

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