Stowers News

Scientists have captured the elusive cell that can regenerate an entire flatworm

Jun 14 2018

KANSAS CITY, MOResearchers at the Stowers Institute for Medical Research have captured the one cell that is capable of regenerating an entire organism. For over a century, scientists have witnessed the effects of this cellular marvel, which enables creatures such as the planarian flatworm to perform death-defying feats like regrowing a severed head. But until recently, they lacked the tools necessary to target and track this cell, so they could watch it in action and discover its secrets.

How epigenetic regulation of the Hoxb gene cluster maintains normal blood-forming stem cells and inhibits leukemia

microscopic image of a human leukemia cells
May 8 2018

KANSAS CITY, MOScientists have known for decades that the Hox family of transcription factors are key regulators in the formation of blood cells and the development of leukemia. Exactly how this large family of genes, which are distributed in four separate chromosomal clusters named A through D, is regulated has been less clear.

Alejandro Sánchez Alvarado elected to the National Academy of Sciences

May 1 2018

KANSAS CITY, MOThe Stowers Institute for Medical Research is pleased to announce that Alejandro Sánchez Alvarado, Ph.D., a Stowers and Howard Hughes Medical Institute (HHMI) investigator, has been elected a member of the prestigious National Academy of Sciences (NAS) for his distinguished and continuing achievements in original scientific research.

Studying blood sugar regulation in cavefish has implications for understanding human diabetes

Mar 21 2018

KANSAS CITY, MOUnderstanding how cavefish have adapted to their extreme environments and how their metabolism is different from surface fish may be relevant for understanding metabolism-related conditions in humans.

Betty Drees, MD, named president of the Graduate School of the Stowers Institute for Medical Research

Mar 1 2018

KANSAS CITY, MOEsteemed physician and educator Betty M. Drees, MD, FACP, was recently appointed president of the Graduate School of the Stowers Institute for Medical Research.

Molecular signature of “trailblazer” neural crest cells gives insight into development and cancer

Dec 4 2017

KANSAS CITY, MOThe term “migration” may evoke grand images of birds flying south for the winter, but this phenomenon also occurs, on a smaller scale, deep within our bodies. Cells migrate whenever embryos develop, wounds heal, cancers metastasize, and immune systems respond to infection. However, the cellular and molecular mechanisms that drive collections of cells as they migrate from one region to another remain unclear.

Marriage of microscopy techniques reveals 3D structure of critical protein complex

Aug 2 2017

KANSAS CITY, MOResearchers at the Stowers Institute for Medical Research have solved the three-dimensional structure of a complex that is essential for the correct sorting of chromosomes into eggs and sperm during reproductive cell division or meiosis.

When this structure, called the synaptonemal complex, doesn't assemble properly in the cell, it can lead to chromosomal abnormalities, miscarriages, and birth defects.

Cancer cells may streamline their genomes in order to proliferate more easily

Jun 22 2017

KANSAS CITY, MOResearch from the Stowers Institute provides evidence suggesting that cancer cells might streamline their genomes in order to proliferate more easily. The study, conducted in both human and mouse cells, shows that cancer genomes lose copies of repetitive sequences known as ribosomal DNA. While downsizing might enable these cells to replicate faster, it also seems to render them less able to withstand DNA damage.

Selfish gene acts as both poison and antidote to eliminate competition

Jun 20 2017

KANSAS CITY, MOResearchers from the Stowers Institute for Medical Research in collaboration with Fred Hutchinson Cancer Research Center researchers have identified an unprecedented genetic survival strategy that would be right at home in an Agatha Christie murder mystery novel.

Genetic cross-talk key to cell balance

Jun 5 2017

KANSAS CITY, MOCompeting regulatory genes "talk" to each other to maintain balance of cell state, according to new research from the Stowers Institute for Medical Research.

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