Stowers News

How old yeast cells send off their daughter cells without the baggage of old age

Nov 23 2011

Kansas City, MO—The accumulation of damaged protein is a hallmark of aging that not even the humble baker’s yeast can escape. Yet, aged yeast cells spawn off youthful daughter cells without any of the telltale protein clumps. Now, researchers at the Stowers Institute for Medical Research may have found an explanation for the observed asymmetrical distribution of damaged proteins between mothers and their youthful daughters.

One for you, one for me: Stowers researchers gain new insight into the chromosome separation process

Nov 17 2011

KANSAS CITY, MO—Each time a cell divides—and it takes millions of cell divisions to create a fully grown human body from a single fertilized cell—its chromosomes have to be accurately divvied up between both daughter cells. Researchers at the Stowers Institute for Medical Research used, ironically enough, the single-celled organism Saccharomyces cerevisiae—commonly known as baker’s yeast—to gain new insight into the process by which chromosomes are physically segregated during cell division.

Pairing up: how chromosomes find each other

Nov 3 2011

KANSAS CITY, MO—After more than a century of study, mysteries still remain about the process of meiosis—a special type of cell division that helps insure genetic diversity in sexually-reproducing organisms. Now, researchers at Stowers Institute for Medical Research shed light on an early and critical step in meiosis.

Joint project by Stowers researchers Blanchette and Si wins 2011 William B. Neaves Award

Oct 27 2011

Kansas City, MO—Stowers assistant investigators Marco Blanchette, Ph.D, and Kausik Si, Ph.D., have been named the 2011 recipients of the William B. Neaves Award. In a joint project, Blanchette and Si will explore how the internal state of an organism impacts the memory storage machinery at the molecular level.

Stowers scientist Matthew Gibson receives 2011 Hudson Prize

Oct 13 2011

Kansas City, MO—Developmental biologist Dr. Matthew C. Gibson, a Stowers Institute assistant investigator, has been named the recipient of the 2011 Hudson Prize by the M.R. and Evelyn Hudson Foundation.

Through the Hudson Prize, the Texas-based M.R. and Evelyn Hudson Foundation recognizes and supports the work of outstanding early career scientists at the Stowers Institute for Medical Research.

Stowers scientists successfully expand bone marrow-derived stem cells in culture

Sep 6 2011

KANSAS CITY, MO—All stem cells—regardless of their source—share the remarkable capability to replenish themselves by undergoing self-renewal. Yet, so far, efforts to grow and expand scarce hematopoietic (or blood-forming) stem cells in culture for therapeutic applications have been met with limited success.

Now, researchers at the Stowers Institute for Medical Research teased apart the molecular mechanisms enabling stem cell renewal in hematopoietic stem cells isolated from mice and successfully applied their insight to expand cultured hematopoietic stem cells a hundredfold.

Going with the flow

Aug 30 2011

KANSAS CITY, MO—Most cells rely on structural tethers to position chromosomes in preparation for cell division. Not so oocytes. Instead, a powerful intracellular stream pushes chromosomes  far-off the center in preparation for the highly asymmetric cell division that completes oocyte maturation upon fertilization of the egg, report researchers at the Stowers Institute for Medical Research.

Newly installed fly-flipping robot up and running at the Stowers Institute

Aug 26 2011

KANSAS CITY, MO—For Stowers researchers “flipping flies”—the tedious chore of transferring fruit flies to vials with fresh food—is a thing of the past. The time-consuming task has been taken over by a custom-designed, fully automated live-transfer robot recently installed at the Stowers Institute for Medical Research; making the institute one of only three research institutions worldwide to operate a fly-flipping robot.

From worm to man: Flatworms provide new insight into organ regeneration and the evolution of mammalian kidneys

Aug 9 2011

KANSAS CITY, MO—Our bodies are perfectly capable of renewing billions of cells every day but fail miserably when it comes to replacing damaged organs such as kidneys. Using the flatworm Schmidtea mediterranea—famous for its capacity to regrow complete animals from minuscule flecks of tissue—as an eloquent example, researchers at the Stowers Institute for Medical Research demonstrated how our distant evolutionary cousins regenerate their excretory systems from scratch.

The unfolding SAGA of transcriptional co-activators

Jul 21 2011

KANSAS CITY, MO—Successful gene expression requires the concerted action of a host of regulatory factors. Long overshadowed by bonafide transcription factors, coactivators—the hanger-ons that facilitate transcription by docking onto transcription factors or modifying chromatin—have recently come to the fore.

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