Stowers News

Joint project by Stowers researchers Blanchette and Si wins 2011 William B. Neaves Award

Oct 27 2011

Kansas City, MO—Stowers assistant investigators Marco Blanchette, Ph.D, and Kausik Si, Ph.D., have been named the 2011 recipients of the William B. Neaves Award. In a joint project, Blanchette and Si will explore how the internal state of an organism impacts the memory storage machinery at the molecular level.

Stowers scientist Matthew Gibson receives 2011 Hudson Prize

Oct 13 2011

Kansas City, MO—Developmental biologist Dr. Matthew C. Gibson, a Stowers Institute assistant investigator, has been named the recipient of the 2011 Hudson Prize by the M.R. and Evelyn Hudson Foundation.

Through the Hudson Prize, the Texas-based M.R. and Evelyn Hudson Foundation recognizes and supports the work of outstanding early career scientists at the Stowers Institute for Medical Research.

Stowers scientists successfully expand bone marrow-derived stem cells in culture

Sep 6 2011

KANSAS CITY, MO—All stem cells—regardless of their source—share the remarkable capability to replenish themselves by undergoing self-renewal. Yet, so far, efforts to grow and expand scarce hematopoietic (or blood-forming) stem cells in culture for therapeutic applications have been met with limited success.

Now, researchers at the Stowers Institute for Medical Research teased apart the molecular mechanisms enabling stem cell renewal in hematopoietic stem cells isolated from mice and successfully applied their insight to expand cultured hematopoietic stem cells a hundredfold.

Going with the flow

Aug 30 2011

KANSAS CITY, MO—Most cells rely on structural tethers to position chromosomes in preparation for cell division. Not so oocytes. Instead, a powerful intracellular stream pushes chromosomes  far-off the center in preparation for the highly asymmetric cell division that completes oocyte maturation upon fertilization of the egg, report researchers at the Stowers Institute for Medical Research.

Newly installed fly-flipping robot up and running at the Stowers Institute

Aug 26 2011

KANSAS CITY, MO—For Stowers researchers “flipping flies”—the tedious chore of transferring fruit flies to vials with fresh food—is a thing of the past. The time-consuming task has been taken over by a custom-designed, fully automated live-transfer robot recently installed at the Stowers Institute for Medical Research; making the institute one of only three research institutions worldwide to operate a fly-flipping robot.

From worm to man: Flatworms provide new insight into organ regeneration and the evolution of mammalian kidneys

Aug 9 2011

KANSAS CITY, MO—Our bodies are perfectly capable of renewing billions of cells every day but fail miserably when it comes to replacing damaged organs such as kidneys. Using the flatworm Schmidtea mediterranea—famous for its capacity to regrow complete animals from minuscule flecks of tissue—as an eloquent example, researchers at the Stowers Institute for Medical Research demonstrated how our distant evolutionary cousins regenerate their excretory systems from scratch.

The unfolding SAGA of transcriptional co-activators

Jul 21 2011

KANSAS CITY, MO—Successful gene expression requires the concerted action of a host of regulatory factors. Long overshadowed by bonafide transcription factors, coactivators—the hanger-ons that facilitate transcription by docking onto transcription factors or modifying chromatin—have recently come to the fore.

Ready, go! Stowers researchers pinpoint the Super Elongation Complex as a major regulator in the coordinated expression of early developmental genes

Jul 15 2011

KANSAS CITY, MO—Just like orchestra musicians waiting for their cue, RNA polymerase II molecules are poised at the start site of many developmentally controlled genes, waiting for the “Go!”- signal to read their part of the genomic symphony.  An assembly of transcription elongation factors known as Super Elongation Complex, or SEC for short, helps paused RNA polymerases to come online and start transcribing the gene ahead, found researchers at the Stowers Institute for Medical Research.

Control of gene expression: Mediator MED26 shifts an idling polymerase into high gear

Jun 5 2011

KANSAS CITY, MO—Look up “transcription”—the copying of a gene’s DNA into RNA intermediaries—in any old molecular biology text book, and it all seems very simple: RNA polymerase II, the enzyme that catalyzes the reaction, assembles at the start site and starts motoring down the strand, cranking out the RNA ribbon used to construct proteins. But researchers now know that RNA polymerase II often stalls on DNA strands where it was once assumed to just barrel down.

Stowers Institute recruits top scientists in developmental and regenerative biology

Jun 20 2011

KANSAS CITY, MO—Renowned developmental biologist Tatjana Piotrowski, Ph.D., and trailblazing regeneration expert Alejandro Sánchez Alvarado, Ph.D., joined the Stowers Institute for Medical Research, the Institute announced today.

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