Stowers News

The worm has turned: new research uncovers processes driving planarian stem cell differentiation in living tissues

Dec 17 2015

KANSAS CITY, MOWith its abundance of stem cells known as neoblasts, and remarkable abilities to restore body parts lost to injury, the humble flatworm, or planaria, has become an exciting model organism to study the processes of tissue and organ regeneration.

Potential biochemical mechanism underlying long-term memories identified

Dec 3 2015

KANSAS CITY, MODuring the holidays, we often remember the past and create new memories. But, why do some memories fade away while others last forever? Scientists at the Stowers Institute for Medical Research have identified a possible biochemical mechanism by which the specialized brain cells known as neurons create and maintain a long-term memory from a fleeting experience.

How a genetic locus protects adult blood-forming stem cells

Dec 1 2015

KANSAS CITY, MOA particular location in DNA, called the Dlk1-Gtl2 locus, plays a critical role in protecting hematopoietic, or blood-forming, stem cells—a discovery revealing a critical role of metabolic control in adult stem cells, and providing insight for potentially diagnosing and treating cancer, according to researchers from the Stowers Institute for Medica

Protein complex links cellular metabolism to gene expression, offers potential therapeutic target

Oct 29 2015

KANSAS CITY, MO—Researchers in the Workman Lab at the Stowers Institute for Medical Research have identified a link between cellular metabolism and gene expression, one with potentially far-reaching implications for cancer risk prediction and treatment.

Stowers investigator receives Innovation Grant from Alex’s Lemonade Stand Foundation

Oct 14 2015

KANSAS CITY, MO—Neuroblastoma is a solid tumor cancer that arises in the nervous system outside the brain and spinal cord and is often fatal in children. The tumors are derived from embryonic neural crest cells that fail to properly migrate or mature. It is known that a variety of molecular signals guide these processes in the embryo, but it is unclear how defects in these signals contribute to the disease. Stowers Institute Director of Imaging Paul Kulesa, Ph.D., has received an Innovation Grant from Alex’s Lemonade Stand Foundation to pursue this very question.

Innovative Imaging Technique Reveals New Cellular Secrets

Sep 16 2015

KANSAS CITY, MO—Cellular mitosis depends in part on small organelles that extend spindles to pull apart chromosome pairs. Before they can perform this and other essential tasks, these tiny cylindrical structures — known as centrioles in animals and spindle pole bodies (SPBs) in yeast — must themselves duplicate.

However, much about this nanoscale process has remained veiled by the limits of current microscopy. Optical approaches cannot resolve objects below certain wavelength limits, while non-optical approaches like electron microscopy (EM) can only study nonliving cells.

Orchestrating hair cell regeneration: a supporting player’s close-up

Jul 16 2015

KANSAS CITY, MO—The older we get, the less likely we are to hear well, as our inner ear sensory hair cells succumb to age or injury. Intriguingly, humans are one-upped by fish here. Similar hair cells in a fish sensory system that dots their bodies and forms the lateral line, by which they discern water movement, are readily regenerated if damage or death occurs.

Stowers Investigator receives American Cancer Society recognition

Jun 8 2015

KANSAS CITY, MO—R. Scott Hawley, Ph.D., Investigator and Dean of the Graduate School at the Stowers Institute for Medical Research, was recognized with a research service award from the regional chapter of the American Cancer Society. Hawley received the award from the High Plains Division of the American Cancer Society at the Cattle Baron’s Ball in Kansas City on June 13, 2015.

Stress triggers key molecule to halt transcription of cell’s genetic code

May 27 2015

KANSAS CITY, MO—If DNA is the cookbook of life, then RNA is the scratch paper where the cell writes down its favorite recipes. These recipes could make the pigments of your skin, the vehicles that carry oxygen through your veins, or the signaling molecules that keep cancer in check. Sometimes, when the cell’s transcription machinery copies these recipes, it stutters or stalls, either because it gets off task or it comes across a problem with the cookbook. Then, the cell has to decide whether to keep going or give up on the recipe.

Stowers Investigator elected to American Academy of Arts and Sciences

Apr 22 2015

KANSAS CITY, MO—Howard Hughes Medical Institute Investigator and Stowers Institute Investigator Alejandro Sánchez Alvarado, Ph.D., has been elected a fellow of the American Academy of Arts and Sciences. Sánchez Alvarado shares the honor with some of the world’s most accomplished leaders from academia, business, public affairs, the humanities and the arts.


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