Stowers News

Ready. Get set. Repress!

Aug 22 2012

Stowers scientists manipulate the Set2 pathway to show how genes are faithfully copied.

KANSAS CITY, MO—The first step in gene expression is the exact copying of a segment of DNA by the enzyme known as RNA polymerase II, or pol II, into a mirror image RNA. Scientists recognize that pol II does not transcribe RNA via a smooth glide down the DNA highway but instead encounters an obstacle course of DNA tightly wound around barrier proteins called histones. Those proteins must be shoved aside for pol II to trundle through. 

Stowers Institute ranked among top three places to work worldwide

Aug 1 2012

KANSAS CITY, MO—The Stowers Institute for Medical Research clocks in among the top three institutions in the annual “Best Places to Work in Academia” survey by The Scientist magazine. The Stowers’ excellent research resources, as well as its management and policies, aimed to encourage an interdisciplinary and collaborative environment, were cited as key factors why scientists working at the institute not only love their work, but also their workplace.

Smell The Potassium

Jul 29 2012

Stowers scientists make a surprising find in study of sex- and aggression-triggering vomeronasal organ

Debate ends: everyone was right

Jul 20 2012

Stowers team reconciles puzzling findings relating to centromere structure

KANSAS CITY, MO—Scientists at the Stowers Institute of Medical Research have developed an innovative method to count the number of fluorescent molecules in a cluster and then applied the novel approach to settle a debate rampant among cell biologists—namely, how DNA twists into a unique chromosomal structure called the centromere. Knowing this helps explain how cells navigate the hazards of division and avoid the disastrous consequences of ending up with the wrong number of chromosomes.

The Yin and Yang of stem cell quiescence and proliferation

Jul 19 2012

Non-canonical Wnt-signaling maintains a quiescent pool of blood-forming stem cells in mouse bone marrow

KANSAS CITY, MO—Not all adult stem cells are created equal. Some are busy regenerating worn out or damaged tissues, while their quieter brethren serve as a strategic back-up crew that only steps in when demand shoots up. Now, researchers at the Stowers Institute for Medical Research have identified an important molecular cue that keeps quiescent mouse hematopoietic (or blood-forming) stem cells from proliferating when their services are not needed.

Stowers Institute launches Original Data Repository

Jul 13 2012

The Stowers Institute for Medical Research announces the public launch of the Stowers Original Data Repository (ODR). As a strong supporter of the scientific ideals of transparency and openness, the Stowers Institute believes that the data underlying its published work should be freely accessible to the scientific community.

Forty’s a crowd

Jun 29 2012

“Paper of the week” shows that a master regulator protein brings plethora of coactivators to gene expression sites

KANSAS CITY, MO—Molecular geneticists call big boss proteins that switch on broad developmental or metabolic programs “master regulators,” as in master regulators of muscle development or fat metabolism. One such factor, the Activating Transcription Factor 6α (ATF6α) protein, takes charge following a cellular crisis known as endoplasmic reticulum (ER) stress, which is triggered by the accumulation of misfolded and aggregated proteins.

Next generation of outstanding researchers recognized through prestigious fellowships and awards

Jun 14 2012

KANSAS CITY, MO—Three successful young Stowers scientists have been named the recipients of highly competitive awards, including a research fellowship from American Cancer Society research fellowship, a prize by the Portuguese Foundation for Science and Technology for an outstanding doctoral thesis in molecular medicine and a DeLill Nasser Award for Professional Development.
 

Pinched off

Jun 11 2012

An actin-ratchet tightens the contractile ring that severs budding daughter cells from their yeast mothers

Stowers scientist Julia Zeitlinger awarded 2012 Hudson Prize

May 23 2012

Kansas City, MO—Dr. Julia Zeitlinger, a Stowers Institute assistant investigator, has been named the recipient of the 2011 Hudson Prize by the M.R. and Evelyn Hudson Foundation.

Through the Hudson Prize, the Texas-based M.R. and Evelyn Hudson Foundation encourages early career scientists to pursue research that leads to important medical breakthroughs and treatments.

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