Publications
Publications
Supporting the scientific spirit of transparency, the Stowers Institute for Medical Research makes the data underlying its scientific publications freely accessible to the scientific community. Access to original, unprocessed data allows other scientists to validate and extend findings made by Stowers researchers.
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Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis.
Lee G, Goretsky T, Managlia E, Dirisina R, Singh AP, Brown JB, May R, Yang GY, Ragheb JW, Evers BM, Weber CR, Turner JR, He XC, Katzman RB, Li L, Barrett TA. Gastroenterology. 2010;139:869-881, 881 e861-869.
Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis.
Brown JB, Lee G, Managlia E, Grimm GR, Dirisina R, Goretsky T, Cheresh P, Blatner NR, Khazaie K, Yang GY, Li L, Barrett TA. Gastroenterology. 2010;138:595-605, 605 e591-593.
Two-photon microscopy and spectral detection for ex vivo imaging of individual stem cells
Wiegraebe W, Xie Y, Yin T, Stark D, Perko K, Alexander R, Schwartz J, He XC, Li L. Nat Protoc in Protoc Ntwk. 2009 doi:10.1038/nprot.2009.1048.
Detection of functional haematopoietic stem cell niche using real-time imaging
Xie Y, Yin T, Wiegraebe W, He XC, Miller D, Stark D, Perko K, Alexander R, Schwartz J, Grindley JC, Park J, Haug JS, Wunderlich JP, Li H, Zhang S, Johnson T, Feldman RA, Li L. Nature. 2009;457:97-101.
N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells
Haug JS, He XC, Grindley JC, Wunderlich JP, Gaudenz K, Ross JT, Paulson A, Wagner KP, Xie Y, Zhu R, Yin T, Perry JM, Hembree MJ, Redenbaugh EP, Radice GL, Seidel C, Li L. Cell Stem Cell.2008;2:367-379.
Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice
Bleuming SA, He XC, Kodach LL, Hardwick JC, Koopman FA, Ten Kate FJ, van Deventer SJ, Hommes DW, Peppelenbosch MP, Offerhaus GJ, Li L, van den Brink GR. Cancer Res.2007;67:8149-8155.
PTEN-deficient intestinal stem cells initiate intestinal polyposis
He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L. Nat Genet.2007;39:189-198.
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, Haug JS, Rupp D, Porter-Westpfahl KS, Wiedemann LM, Wu H, Li L. Nature. 2006;441:518-522.
Sterile and disposable fluidic subsystem suitable for clinical high speed fluorescence-activated cell sorting
Jayasinghe SM, Wunderlich J, McKee A, Newkirk H, Pope S, Zhang J, Staehling-Hampton K, Li L, Haug JS. Cytometry B Clin Cytom.2006;70:344-354.
Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion
Zhang J, He XC, Tong WG, Johnson T, Wiedemann LM, Mishina Y, Feng JQ, Li L. Stem Cells.2006;24:2826-2839.
Cre-mediated site-specific recombination in zebrafish embryos
Thummel R, Burket CT, Brewer JL, Sarras MP, Jr., Li L, Perry M, McDermott JP, Sauer B, Hyde DR, Godwin AR. Dev Dyn.2005;233:1366-1377.
Identifying the Patterns of Hematopoietic Stem Cells Geneusing Using Clustering Methods: Comparison and Summary
Chen J, He X, Li L. J Data Sci. 2004;2:297-309.
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling
He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, Mishina Y, Li L. Nat Genet.2004;36:1117-1121.
Proteomic analysis identifies that 14-3-3{zeta} interacts with {beta}-catenin and facilitates its activation by Akt
Tian Q, Feetham MC, Tao WA, He XC, Li L, Aebersold R, Hood L. Proc Natl Acad Sci U S A.2004.
Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis
AkashiK, He X, Chen J, Iwasaki H, Niu C, Steenhard B, Zhang J, Haug J, Li L. Blood. 2003;101:383-389.
Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischemia-reperfusion injury in mice
Lin F, Cordes K, Li L, Hood L, Couser WG, Shankland SJ, Igarashi P. J Am Soc Nephrol. 2003;14:1188-1199.
Activated Notch4 Inhibits Angiogenesis: Role of beta1-Integrin Activation
Leong KG, Hu X, Li L, Noseda M, Larrivee B, Hull C, Hood L, Wong F, Karsan A. Mol Cell Biol. 2002;22:2830-2841.
Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis
Ning XH, Chen SH, Xu CS, Li L, Yao LY, Qian K, Krueger JJ, Hyyti OM, Portman MA. J Appl Physiol. 2002;92:2200-2207.
Differential gene expression profiling of adult murine hematopoietic stem cells
Park IK, He Y, Lin F, Laerum OD, Tian Q, Bumgarner R, Klug CA, Li K, Kuhr C, Doyle MJ, Xie T, Schummer M, Sun Y, Goldsmith A, Clarke MF, Weissman IL, Hood L, Li L. Blood. 2002;99:488-498.
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Unraveling the molecular components and genetic blueprints of stem cells
Li L, Akashi K. BioTechniques. 2003;35:1233-1239.
25-year mystery unveiled: Hematopoietic stem cell niche is found
Zhang J, Li L. Discov Med. 2003;3:55-58.
Q & A
Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, Haug JS, Rupp D, Porter-Westpfahl KS, Wiedemann LM, Wu H, Li L. Nature.2006;441:519-522.
Identification of the haematopoietic stem cell niche and control of the niche size
Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, Ross J, Haug J, Johnson T, Feng JQ, Harri S, Wiedemann LM, Mishina Y, Li L. Nature. 2003;425:836-841
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