Publications
Publications
Supporting the scientific spirit of transparency, the Stowers Institute for Medical Research makes the data underlying its scientific publications freely accessible to the scientific community. Access to original, unprocessed data allows other scientists to validate and extend findings made by Stowers researchers.
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Understanding and Overcoming Immunosuppression Shaped by Cancer Stem Cells
Li L, Jensen RA. Cancer Res. 2023;83:2096-2104.
Dynamic regulation and requirement for ribosomal RNA transcription during mammalian development
Falcon KT, Watt KEN, Dash S, Zhao R, Sakai D, Moore EL, Fitriasari S, Childers M, Sardiu ME, Swanson S, Tsuchiya D, Unruh J, Bugarinovic G, Li L, Shiang R, Achilleos A, Dixon J, Dixon MJ, Trainor PA. Proc Natl Acad Sci U S A. 2022;119:e2116974119 doi: 10.1073/pnas.2116974119.
Lack of VMP1 Impairs Hepatic Lipoprotein Secretion and Promotes Nonalcoholic Steatohepatitis
Jiang X, Fulte S, Deng F, Chen S, Xie Y, Chao X, He XC, Zhang Y, Li T, Li F, McCoin C, Morris EM, Thyfault J, Liu W, Li L, Davidson NO, Ding WX, Ni HM. Lack of VMP1 Impairs Hepatic Lipoprotein Secretion and Promotes Nonalcoholic Steatohepatitis. [Published ahead of print April 23 2022]. J Hepatol. 2022.
Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche
He X, Smith SE, Chen S, Li H, Wu D, Meneses-Giles PI, Wang Y, Hembree M, Yi K, Zhao X, Guo F, Unruh JR, Maddera LE, Yu Z, Scott A, Perera A, Wang Y, Zhao C, Bae K, Box A, Haug JS, Tao F, Hu D, Hansen DM, Qian P, Saha S, Dixon D, Anant S, Zhang D, Lin EH, Sun W, Wiedemann LM, Li L. Cell Rep. 2021;36:109674.doi: 10.1016/j.celrep.2021.109674.
Proteome plasticity in response to persistent environmental change
Domnauer M, Zheng F, Li L, Zhang Y, Chang CE, Unruh JR, Conkright-Fincham J, McCroskey S, Florens L, Zhang Y, Seidel C, Fong B, Schilling B, Sharma R, Ramanathan A, Si K, Zhou C. Mol Cell. 2021;81:3294-3309 e3212.
Double emulsions with ultrathin shell by microfluidic step-emulsification
Ge X, Rubinstein BY, He Y, Bruce FNO, Li L, Leshansky AM, Li Z. Lab Chip. 2021;21:1613-1622.
b-Catenin and Associated Proteins Regulate Lineage Differentiation in Ground State Mouse Embryonic Stem Cells
Tao F, Soffers J, Hu D, Chen S, Gao X, Zhang Y, Zhao C, Smith SE, Unruh JR, Zhang D, Tsuchiya D, Venkatraman A, Zhao M, Li Z, Qian P, Parmely T, He XC, Washburn M, Florens L, Perry JM, Zeitlinger J, Workman J, Li L. Stem Cell Rep. 2020;15:662-676.
Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates
Wang W, Hu CK, Zeng A, Alegre D, Hu D, Gotting K, Ortega Granillo A, Wang Y, Robb S, Schnittker R, Zhang S, Alegre D, Li H, Ross E, Zhang N, Brunet A, Sanchez Alvarado A. Science. 2020;369: eaaz3090. doi: 10.1126/science.aaz3090.
FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling
Wu J, Tian Y, Han L, Liu C, Sun T, Li L, Yu Y, Lamichhane B, D'Souza RN, Millar SE, Krumlauf R, Ornitz DM, Feng JQ, Klein O, Zhao H, Zhang F, Linhardt RJ, Wang X. BMC Biol. 2020;18:87. doi.org/10.1186/s12915-12020-00813-12914.
Overcoming Wnt-beta-catenin dependent anticancer therapy resistance in leukaemia stem cells
Perry JM, Tao F, Roy A, Lin T, He XC, Chen S, Lu X, Nemechek J, Ruan L, Yu X, Dukes D, Moran A, Pace J, Schroeder K, Zhao M, Venkatraman A, Qian P, Li Z, Hembree M, Paulson A, He Z, Xu D, Tran TH, Deshmukh P, Nguyen CT, Kasi RM, Ryan R, Broward M, Ding S, Guest E, August K, Gamis AS, Godwin A, Sittampalam GS, Weir SJ, Li L. Nat Cell Biol. 2020;22:689-700
p53 and b-Catenin Expression Predict Poorer Prognosis in Patients With Anaplastic Large-Cell Lymphoma
Richardson AI, Yin CC, Cui W, Li N, Medeiros LJ, Li L, Zhang D. Clin Lymphoma Myeloma Leuk. 2019;19:e385-e392. doi: 310.1016/j.clml.2019.1003.1030.
Translation affects mRNA stability in a codon-dependent manner in human cells
Wu Q, Medina SG, Kushawah G, DeVore ML, Castellano LA, Hand JM, Wright M, Bazzini AA. eLife. 2019;8:e45396. doi: 45310.47554/eLife.45396.
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells
Zhao M, Tao F, Venkatraman A, Li Z, Smith SE, Unruh J, Chen S, Ward C, Qian P, Perry JM, Marshall H, Wang J, He XC, Li L. Cell Rep. 2019;26:652-669 e656.
Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice
Chao X, Wang S, Zhao K, Li Y, Williams JA, Li T, Chavan H, Krishnamurthy P, He XC, Li L, Ballabio A, Ni HM, Ding WX. Gastroenterology. 2018.
Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion
Li Z, Qian P, Shao W, Shi H, He XC, Gogol M, Yu Z, Wang Y, Qi M, Zhu Y, Perry JM, Zhang K, Tao F, Zhou K, Hu D, Han Y, Zhao C, Alexander R, Xu H, Chen S, Peak A, Hall K, Peterson M, Perera A, Haug JS, Parmely T, Li H, Shen B, Zeitlinger J, He C, Li L. Cell Res. 2018. Author Correction: Cell Res 2018:1-14. doi.org/10.1038/s41422-018-0072-0. Published online July 2018.;28:904-917.
The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow
Shao L, Chang J, Feng W, Wang X, Williamson EA, Li Y, Schajnovitz A, Scadden D, Mortensen LJ, Lin CP, Li L, Paulson A, Downing J, Zhou D, Hromas RA. Nat Commun.2018;9:2377. doi: 2310.1038/s41467-41018-04716-41465.
Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis
Qian P, De Kumar B, He XC, Nolte C, Gogol M, Ahn Y, Chen S, Li Z, Xu H, Perry JM, Hu D, Tao F, Zhao M, Han Y, Hall K, Peak A, Paulson A, Zhao C, Venkatraman A, Box A, Perera A, Haug JS, Parmely T, Li H, Krumlauf R, Li L. Cell Stem Cell.2018;22:740-754 e747.
Beta-catenin cleavage enhances transcriptional activation
Goretsky T, Bradford EM, Ye Q, Lamping OF, Vanagunas T, Moyer MP, Keller PC, Sinh P, Llovet JM, Gao T, She QB, Li L, Barrett TA. Sci Rep.2018;8:671. doi: 10.1038/s41598-017-18421-8.
H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of epithelial cell adhesion molecule
Song Y, Liu C, Liu X, Trottier J, Beaudoin M, Zhang L, Pope C, Peng G, Barbier O, Zhong X, Li L, Wang L. Hepatology.2017;66:1183-1196.
Myo-inositol reduces beta-catenin activation in colitis
Bradford EM, Thompson CA, Goretsky T, Yang GY, Rodriguez LM, Li L, Barrett TA. World J Gastroenterol.2017;23:5115-5126.
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Stress-protecting harbors for hematopoietic stem cells
Yang Z, Dong R, Mao X, He XC, Li L. [published ahead of print November 24 2023]. Curr Opin Cell Biol. 2023;86:102284.
YTHDF3 as a new player in hematopoietic stem cell regulation
Mao X, Li L. Haematologica. 2022;107:2290-2291.
p57Kip2 indirectly regulates AGM HSCs
Mao X, Li L. Blood. 2022;140:411-412.
In Situ Hematopoietic Stem Cell Imaging
Venkatraman A, Smith SE, Pinho S, Zhao M, Li L, Frenette P. Methods Mol Biol. 2021;2185:373-382.
Overcoming resistance to immunotherapy by teaching old drugs new tricks
Perry JM, Li L. Mol Cell Oncol. 2020;7:e1801088. doi: 10.1080/23723556.2020.1801088.
Atlas of the human intestine
He XC, Li L. Atlas of the human intestine. J Exp Med. 2020;217:e20191997. doi: 20191910.20191084/jem.20191997.
Intestinal epithelial regeneration: active versus reserve stem cells and plasticity mechanisms
Karmakar S, Deng L, He XC, Li L. Am J Physiol Gastrointest Liver Physiol. 2020;318:G796-G802.
Hematopoietic Stem Cells: Self-renewal and Expansion
Li Z, He XC, Li L. Curr Opin Hematol. 2019;26:258-265.
Niche cells rewired to maintain HSCs ex vivo
Venkatraman A, Li L. Nat Cell Biol. 2019;21:540-541.
Observation of two separate bipolar spindles in the human zygote
Xu, X., Li L, Zhang C, Meng L. J Assist Reprod Genet. 2019;36:601-602. Correction: J Assist Reprod Genet. 2019 Jul 31. pii: 10.1007/s10815-019-01539-1. doi: 10.1007/s10815-019-01539-1.
Recent advances in understanding intestinal stem cell regulation
Hu D, Yan H, He XC, Li L. F1000Res. 2019;8:F1000 Faculty Rev-72. Published 2019 Jan 18. doi:10.12688/f1000research.16793.1
Translational Control by Prion-like Proteins
Li L, McGinnis JP, Si K. Trends Cell Biol.2018;28:494-505.
Hierarchy and Plasticity in the Intestinal Stem Cell Compartment
Yousefi M, Li L, Lengner CJ. Hierarchy and Plasticity in the Intestinal Stem Cell Compartment. Trends Cell Biol.2017;27:753-764.
Regulation of hematopoietic stem cell dynamics by molecular niche signaling
Venkatraman A, Zhao M, Perry J, He X, Li L. Biology and Engineering of Stem Cell Niches; 2017:51-61.
When LIN41 Comes to a Fork in the Road, It Takes BOTH Paths: Translational Repression OR mRNA Decay, Depending on the Target Site Position
Hand JM, Bazzini AA. Mol Cell.2017;65:375-377.
The regulatory niche of intestinal stem cells
Sailaja BS, He XC, Li L. J Physiol.2016;594:4827-4836.
Stem Cells and Regeneration in the Digestive System: Keystone Meeting
Soffers JH, Hansen D, Sinagoga KL, Li B, Martin MG, Wells J, Grompe M, Li L. Gastroenterology.2016;151:e6-9.
Single-cell RNA-seq technology lends a hand into HSC ontogeny
Qian P, Li L. Sci China Life Sci. 2016. doi: 10.1007/s11427-016-5092-8.
Dissecting the bone marrow HSC niches
Zhao M, Li L. Cell Res.2016;26:975-976.
Stem Cells Matter in Response to Fasting
Sailaja BS, He XC, Li L. Cell Rep. 2015;13:2325-2326.
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