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Supporting the scientific spirit of transparency, the Stowers Institute for Medical Research makes the data underlying its scientific publications freely accessible to the scientific community. Access to original, unprocessed data allows other scientists to validate and extend findings made by Stowers researchers.


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Proteome-Wide Identification of RNA-Dependent Proteins: An Emerging Role of RNAs in Plasmodium falciparum Protein Complexes

Hollin T, Abel S, Banks C, Hristov B, Prudhomme J, Hales K, Florens L, Stafford Noble W, Le Roch KG. Nat Commun. 2024;15:1365 doi: 10.1038/s41467-024-45519-1.

Distinct states of nucleolar stress induced by anti-cancer drugs

Potapova T, Unruh J, Conkright-Fincham J, Banks CAS, Florens L, Schneider DHG, Gerton JL. eLife. 2023.

Metabolic reprogramming underlies cavefish muscular endurance despite loss of muscle mass and contractility

Olsen L, Levy M, Medley JK, Hassan H, Miller B, Alexander R, Wilcock E, Yi K, Florens L, Weaver K, McKinney SA, Peuss R, Persons J, Kenzior A, Maldonado E, Delventhal K, Gluesenkamp A, Mager E, Coughlin D, Rohner N. Proc Natl Acad Sci U S A. 2023;120:e2204427120.

FGF2 antiproliferative effect in K-ras-driven tumor cells involves modulation of rRNA and nucleolus

de Luna Vitorino FN, Levy MJ, Mansano Wailemann RA, Lopes M, Silva ML, Sardiu ME, Garcia BA, Motta MCM, Oliveira CC, Armelin HA, Florens LA, Washburn MP, da Cunha JPC. [published ahead of print Novermber 3 2023]. J Cell Sci. 2023.

A Borrelia burgdorferi LptD homolog is required for flipping of surface lipoproteins through the spirochetal outer membrane

He H, Pramanik AS, Swanson SK, Johnson DK, Florens L, Zuckert WR. Mol Microbiol. 2023;119:752-767.

Paraspeckles interact with SWI/SNF subunit ARID1B to regulate transcription and splicing

Reddy D, Bhattacharya S, Levy M, Zhang Y, Gogol M, Li H, Florens L, Workman JL. EMBO Rep 2023;24:e55345 doi: 10.15252/embr.202255345.

The Caenorhabditis elegans ASPP homolog APE-1 is a junctional protein phosphatase 1 modulator

Beacham GM, Wei DT, Beyrent E, Zhang Y, Zheng J, Camacho MMK, Florens L, Hollopeter G. Genetics. 2022;222 doi: 10.1093/genetics/iyac102.

An apical protein, Pcr2, is required for persistent movement by the human parasite Toxoplasma gondii

Munera Lopez J, Tengganu IF, Liu J, Murray JM, Arias Padilla LF, Zhang Y, Brown PT, Florens L, Hu K. PLoS Pathog. 2022;18:e1010776 doi: 10.1371/journal.ppat.1010776.

Mediator recruits the cohesin loader Scc2 to RNA Pol II transcribed genes and promotes sister chromatid cohesion

Mattingly M, Seidel C, Munoz S, Hao Y, Zhang Y, Wen Z, Florens L, Uhlmann F, Gerton JL. [published ahead of print June 3 2022]. Curr Biol. 2022;32.

Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum

Hollin T, Abel S, Falla A, Pasaje CFA, Bhatia A, Hur M, Kirkwood JS, Saraf A, Prudhomme J, de Souza A, Florens L, Niles JC, Le Roch KG. Nat Commun. 2022;13:1275. doi: 1210.1038/s41467-41022-28981-41467.

A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis

Paez-Moscoso DJ, Ho DV, Pan L, Hildebrand K, Jensen KL, Levy MJ, Florens L, Baumann P. Nat Commun. 2022;13:1067. doi: 1010.1038/s41467-41022-28545-41469.

Cytidine acetylation yields a hypoinflammatory synthetic messenger RNA

Nance KD, Gamage ST, Alam MM, Yang A, Levy MJ, Link CN, Florens L, Washburn MP, Gu S, Oppenheim JJ, Meier JL. Cell Chem Biol. 2022;29:312-320 e317.

MOCS2 links nucleotide metabolism to nucleoli function

Suganuma T, Swanson SK, Gogol M, Garrett TJ, Florens L, Workman JL. J Mol Cell Biol. 2022;13:838-840.

Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing

Bhattacharya S, Wang S, Reddy D, Shen S, Zhang Y, Zhang N, Li H, Washburn MP, Florens L, Shi Y, Workman JL, Li F. Nat Commun. 2021;12:6452. doi: 6410.1038/s41467-41021-26799-41463.

Multiple roles for PARP1 in ALC1-dependent nucleosome remodeling

Ooi SK, Sato S, Tomomori-Sato C, Zhang Y, Wen Z, Banks CAS, Washburn MP, Unruh JR, Florens L, Conaway RC, Conaway JW.  Proc Natl Acad Sci U S A. 2021;118:e2107277118. doi: 2107277110.2107271073/pnas.2107277118.

Decellularization enables functional analysis of ECM remodeling in planarian regeneration

Sonpho E, Mann FG, Jr., Levy M, Ross EJ, Guerrero-Hernandez C, Florens L, Saraf A, Doddihal V, Ounjai P, Sánchez Alvarado A. Mol Cell Proteomics. 2021:100137.  doi: 100110.101016/j.mcpro.102021.100137.

Proteome plasticity in response to persistent environmental change

Domnauer M, Zheng F, Li L, Zhang Y, Chang CE, Unruh JR, Conkright-Fincham J, McCroskey S, Florens L, Zhang Y, Seidel C, Fong B, Schilling B, Sharma R, Ramanathan A, Si K, Zhou C. Mol Cell. 2021;81:3294-3309 e3212.

The disordered regions of the methyltransferase SETD2 govern its function by regulating its proteolysis and phase separation

Bhattacharya S, Lange JJ, Levy M, Florens L, Washburn MP, Workman JL. J Biol Chem. 2021:101075.

K63-linked ubiquitination of DYRK1A by TRAF2 alleviates Sprouty2 mediated degradation of EGFR

Zhang P, Zhang Z, Fu Y, Zhang Y, Washburn MP, Florens L, Wu M, Huang C, Hou Z, Mohan M. Cell Death Dis. 2021;12:608.

The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain

Bhattacharya S, Levy MJ, Zhang N, Li H, Florens L, Washburn MP, Workman JL. Nat Commun. 2021;12:1443. doi: 1410.1038/s41467-41021-21663-w.

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Second Special Issue on Methods for Omics Research: Proteome Research and Beyond

Florens L, Dong MQ, LaBaer J. J Proteome Res. 2023;22:1381-1384.

Multiplexed Quantitative Proteomics Analysis of Developing Human Brain Organoids

Florens L, Saraf A, Hao Y, Zhang Y, Wang Y, Parmely TJ, Zhao C, Washburn MP. In: W Wang, Y Wang, and N Rohner, eds. Emerging Model Organisms; 2023;194:325-355.

To Bead or not to Bead? That is the question with cross-linking mass spectrometry.

Florens L, Hao Y, Zhang Y, Wen Z, Banks CAS, Washburn MP.  J Biomol Tech : JBT. 2020;31:S24.

New and Improved Tools for the Omics Crew

Florens, L., Dong, M.-Q., LaBaer, J. J Proteome Res 2020;19:2525-2528. doi:10.1021/acs.jproteome.0c00328.

Advancement of mass spectrometry-based proteomics technologies to explore triple negative breast cancer

Miah S, Banks CA, Adams MK, Florens L, Lukong KE, Washburn MP. Mol Biosyst.2016;13:42-55.

Isolation, Proteomic Analysis, and Microscopy Confirmation of the Liver Nuclear Envelope Proteome

Korfali N, Florens L, Schirmer EC. Methods Mol Biol. 2016;1411:3-44.

Use of sequential chemical extractions to purify nuclear membrane proteins for proteomics identification.

Korfali N, Fairley EA, Swanson SK, Florens L, Schirmer EC. Methods Mol Biol. 2009;528:201-225.

Generation and analysis of multidimensional protein identification technology datasets

Swanson SK, Florens L, Washburn MP. Methods Mol Biol. 2009;492:1-20.

Detecting Pathological Pathways of a Complex Disease by a Comparative Analysis of Networks

Florens L, Korfali N, Schirmer EC, Emmert-Streib F, Dehmer M. In: F Emmert-Streib, and M Dehmer, eds. Analysis of Microarray Data: A Network-Based Approach. Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA; 2008:285-305.

Subcellular Fractionation and Proteomics of Nuclear Envelopes

Florens L, Korfali N, Schirmer EC. Methods Mol Biol. 2008;432:117-137.

Genome Comparison and Proteomic Characterization of Thermus thermophilus Bacteriophages P23-45 and P74-26: Siphoviruses with Triplex-forming Sequences and the Longest Known Tails.

Minakhin L, Goel M, Berdygulova Z, Ramanculov E, Florens L, Glazko G, Karamychev VN, Slesarev AI, Kozyavkin SA, Khromov I, Ackermann HW, Washburn M, Mushegian A, Severinov K. J Mol Biol.2008;378:468-480.

Analyzing chromatin remodeling complexes using shotgun proteomics and normalized spectral abundance factors

Florens L, Carozza MJ, Swanson SK, Fournier M, Coleman MK, Workman JL, Washburn MP. Methods.2006;40:303-311.

Proteomic analysis by multidimensional protein identification technology

Florens L, Washburn MP. Methods in Molecular Biology: New and Emerging Proteomics Techniques. Totowa, NJ: Humana Press Inc.; 2006;328:159-175.

The mammalian Mediator complex

Conaway JW, Florens L, Sato S, Tomomori-Sato C, Parmely TJ, Yao T, Swanson SK, Banks CAS, Washburn MP, Conaway RC. FEBS Lett.2005;579:904-908.

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