Qian P, De Kumar B, He XC, Nolte C, Gogol M, Ahn Y, Chen S, Li Z, Xu H, Perry JM, Hu D, Tao F, Zhao M, Han Y, Hall K, Peak A, Paulson A, Zhao C, Venkatraman A, Box A, Perera A, Haug JS, Parmely T, Li H, Krumlauf R, Li L. Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis. Cell Stem Cell.2018;22:740-754 e747. Abstract | Original Data
Li Z, Qian P, Shao W, Shi H, He XC, Gogol M, Yu Z, Wang Y, Qi M, Zhu Y, Perry JM, Zhang K, Tao F, Zhou K, Hu D, Han Y, Zhao C, Alexander R, Xu H, Chen S, Peak A, Hall K, Peterson M, Perera A, Haug JS, Parmely T, Li H, Shen B, Zeitlinger J, He C, Li L. Suppression of m(6)A reader Ythdf2 promotes hematopoietic stem cell expansion. Cell Res.2018. Author Correction: Cell Res 2018:1-14. https://doi.org/10.1038/s41422-018-0072-0. Published online July 2018.;28:904-917. Abstract | Original Data
Qian P, He XC, Paulson A, Li Z, Tao F, Perry JM, Guo F, Zhao M, Zhi L, Venkatraman A, Haug JS, Parmely T, Li H, Dobrowsky RT, Ding WX, Kono T, Ferguson-Smith AC, Li L. The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism. Cell Stem Cell.2016;18:214-228. Abstract | Original Data | Journal Cover | Featured in: Serrano-Lopez J, Cancelas JA. Mom Knows Best: Imprinted Control of Hematopoietic Stem Cell Quiescence. Cell Stem Cell.2016;18:158-160.
Zhao M, Perry JM, Marshall H, Venkatraman A, Qian P, He XC, Ahamed J, Li L. Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells. Nat Med.2014;20:1321-1326. News & Views, Abstract | Original Data
Venkatraman A, He XC, Thorvaldsen JL, Sugimura R, Perry JM, Tao F, Zhao M, Christenson MK, Sanchez R, Yu JY, Peng L, Haug JS, Paulson A, Li H, Zhong XB, Clemens TL, Bartolomei MS, Li L. Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence. Nature. 2013;500:345-349. Abstract. Featured in: Goodell MA. Parental Permissions: H19 and Keeping the Stem Cell Progeny under Control. Cell Stem Cell.2013;13:137-138.
Wang F, Scoville D, He XC, Mahe MM, Box A, Perry JM, Smith NR, Lei NY, Davies PS, Fuller MK, Haug JS, McClain M, Gracz AD, Ding S, Stelzner M, Dunn JC, Magness ST, Wong MH, Martin MG, Helmrath M, Li L. Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay. Gastroenterology.2013;145:383-395 e321. Abstract | Original Data
Featured in: Lowe AW, Moseley RH. Covering the cover. Gastroenterology.2013;145:263-265.
Zhao M, Ross JT, Itkin T, Perry JM, Venkatraman A, Haug JS, Hembree MJ, Deng CX, Lapidot T, He XC, Li L. FGF signaling facilitates post-injury recovery of mouse hematopoietic system. Blood.2012;120:1831-1842. Abstract
Sugimura R, He XC, Venkatraman A, Arai F, Box A, Semerad C, Haug JS, Peng L, Zhong XB, Suda T, Li L. Noncanonical wnt signaling maintains hematopoietic stem cells in the niche. Cell. 2012;150:351-365. Abstract
Perry JM, He XC, Sugimura R, Grindley JC, Haug JS, Ding S, Li L. Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion. Genes Dev.2011;25:1928-1942. Abstract | Journal Cover | Original Data
Li L, Clevers H. Coexistence of quiescent and active adult stem cells in mammals. Science.2010;327:542-545. Abstract
Xie Y, Yin T, Wiegraebe W, He XC, Miller D, Stark D, Perko K, Alexander R, Schwartz J, Grindley JC, Park J, Haug JS, Wunderlich JP, Li H, Zhang S, Johnson T, Feldman RA, Li L. Detection of functional hematopoietic stem cell niche using ex vivo real-time imaging. Nature.2009;457:97-101. Abstract and Editor's Summary.
Haug JS, He XC, Grindley JC, Wunderlich JP, Gaudenz K, Ross JT, Paulson A, Wagner KP, Xie Y, Zhu R, Yin T, Perry JM, Hembree MJ, Redenbaugh EP, Radice GL, Seidel C, Li L. N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells. Cell Stem Cell.2008;2:367-379.Abstract & Highlight.
Perry JM, Li L. Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis. Genes Dev.2008;22:1107-1109. Abstract
Perry JM, Li L. Disrupting the stem cell niche: good seeds in bad soil. Cell.2007;129:1045-1047. Abstract
He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L. PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet.2007;39:189-198. Abstract
Zhang J, He XC, Tong WG, Johnson T, Wiedemann LM, Mishina Y, Feng JQ, Li L. Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion. Stem Cells.2006;24:2826-2839. Abstract
Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, Haug JS, Rupp D, Porter-Westpfahl KS, Wiedemann LM, Wu H, Li L. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature.2006;441:519-522. Cover, News & Views., Abstract, and corrected Sup-Fig.4.
Li L. Finding the hematopoietic stem cell niche in the placenta. Dev Cell.2005;8:297-298. Abstract
Tian Q, Feetham MC, Tao WA, He XC, Li L, Aebersold R, Hood L. Proteomic analysis identifies that 14-3-3{zeta} interacts with {beta}-catenin and facilitates its activation by Akt. Proc Natl Acad Sci U S A.2004;101:15370-15375. Abstract
He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, Mishina Y, Li L. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-atenin signaling. Nat Genet.2004;36:1117-1121. Abstract, The comments regarding this paper News and Views.
Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, Ross J, Haug J, Johnson T, Feng JQ, Harri S, Wiedemann LM, Mishina Y, Li L.. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003;425:836-841. Abstract, a Featured Article. by Nature.
Akashi K, He X, Chen J, Iwasaki H, Niu C, Steenhard B, Zhang J, Haug J and Li L. Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood. 2003;101.2:383-389. Abstract, The comments regarding this paper Comments.
Park I, He Y, Lin F, Laerum O, Tian Q, Bumgarner R, Klug C, Li K, Kuhr C, Doyle M, Xie X, Schummer M, Sun Y, Goldsmith A, Clarke M, Weissman I, Hood L, Li L. Differential Gene Expression Profiling of Adult Murine Hematopoietic Stem Cells. Blood. 2002;99:488-498. Abstract
Terskikh AV, Easterday MC, Li L, Hood L, Kornblum HI, Geschwind DH, Weissman IL. From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci USA. 2001;98:7934-7939. Abstract.
Li L, Milner L, Deng Y, Iwata W, Banta A, Graf L, Marcovina S, Friedman C, Trask B, Hood L, Torok-Storb B. The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. Immunity. 1998;8:43-55. Abstract
Li L, Krantz ID, Deng Y, Genin A, Banta A, Collins C, Qi M, Trask BJ, Kuo W, Cochran J, Costa T, Pierpont MEM, Rand EB, Piccoli D, Hood L, Spinner N. Alagille syndrome is caused by mutations in hJagged1 (JAG1), which encodes a ligand for Notch1. NatGenet. 1997;16:243-251. Abstract.
Lee TC, Li L, Philipson L, Ziff EB. Myc represses transcription of the growth arrest gene gas-1. Proc Natl Acad Sci USA. 1997;94:12886-12891. Abstract.
Li L, Nerlov C, Prendergast G, MacGregor D, Ziff EB. c-Myc represses transcription by a novel mechanism dependent on the initiator element and Myc box II. EMBO J. 1994;13:4070-4079. Abstract.
Invited Reviews, Previews, and Book Chapters
Scoville DH, Sato T, He XC, Li L. Current view: intestinal stem cells and signaling. Gastroenterology.2008;134:849-864. Abstract
Scoville DH, He XC, Lee G, Sato T, Barrett TA, Li L. Intestinal Stem Cells in Physiologic Regeneration and Disease. In: Principles of Developmental Genetics. 1st Ed. Burlington, MA: Elsevier Inc., Academic Press; 2007.
Yin T, Li L. The stem cell niches in bone. J Clin Invest.2006;116:1195-1201. Abstract
Li L, Neaves WB. Normal stem cells and cancer stem cells: the niche matters. Cancer Res.2006;66:4553-4557. Abstract
Ross J, Li L. Recent advances in understanding extrinsic control of hematopoietic stem cell fate. Curr Opin Hematol.2006;13:237-242. Abstract
Li Z, Li L. Understanding hematopoietic stem-cell microenvironments. Trends Biochem Sci.2006;31:589-595. Abstract
Li L, Xie T. Stem cell niche: structure and function. Annu Rev Cell Dev Biol.2005;21:605-631. Abstract
He XC, Zhang J, Li L. Cellular and molecular regulation of hematopoietic and intestinal stem cell behavior. Ann N Y Acad Sci.2005;1049:28-38. Abstract
Zhang J, Li L. BMP signaling and stem cell regulation. Dev Biol.2005;284:1-11. Abstract