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Özel Lab

Our research integrates developmental neurobiology with systems biology and gene regulation with the goal of understanding brain wiring.

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Research Summay

How does the brain develop?

Research Areas

Neuroscience, Development and Regeneration, Genetics and Genomics, Molecular and Cell Biology, Systems Biology


Fruit flies

The Özel Lab investigates how neurons differentiate into different types with distinct functions and connections during development. The lab seeks to uncover the gene regulatory mechanisms responsible for governing neuronal cell fate and circuitry.

The Özel Lab will be an interdisciplinary, international, and collaborative team of computational and experimental biologists working together with the goal of understanding brain development. The lab anticipates that insights from their research will have broad translational applications such as inducing stem cells to differentiate into specific neuronal types for cell replacement therapy.

Assistant Investigator

Neşet Özel

Assistant Investigator

Stowers Institute for Medical Research

Why study fruit flies?

Fruit fly up close

Gaining a thorough understanding of the molecular mechanisms that underlie neuronal diversity and synaptic connectivity is our only hope to ever have effective treatments for a variety of neurodevelopmental disorders, most notably autism. However, we still lack the tools and the depth of understanding to comprehensively address these questions at the level of complexity of mammalian brains.

Thus, our research focuses on the Drosophila visual system, the premier model nervous system whose cell-type diversity and connectome has been described in great detail, providing the ideal balance between complexity and accessibility.

Combined with the powerful genetic tools we can take advantage of in flies, this allows us to answer the most fundamental questions about brain development that are too intractable in “higher” organisms.

tSNE visualization of the single-cell transcriptomes acquired from adult Drosophila optic lobes (Özel et al. 2021, Nature). Clusters annotated to specific neuronal types are represented by their standard abbreviations. Other clusters are represented by their number.

Lab Philosophy

The Özel Lab will be an interdisciplinary team of computational and experimental biologists, working together with the singular goal of understanding brain development.

We are a question-driven lab that does not hesitate to explore and adopt a wide range of cutting-edge tools and methods to address the most challenging aspects of this overarching question. All our members, regardless of their background, are encouraged to train in both “wet” and “dry” lab techniques to realize their full potential.

The lab believes that an inclusive environment where ideas and concerns are shared openly is essential for the advancement of science; thus we celebrate the diversity of opinions and perspectives afforded to us by our highly international and collaborative environment.

More about the Özel Lab's research

Neuronal type identity is central to the development and function of neural circuits, as it instructs both the connectivity of neurons as well as their physiological properties. Our previous work has identified the combinations of transcription factors (terminal selectors) that encode the unique identity of ~200 distinct neurons in the Drosophila visual system. Connectivity of this circuit is genetically “hardwired” and highly stereotypical: each neuronal cell type will only form synapses with a specific subset of other neuronal types in its vicinity while avoiding others. While this implies that terminal selectors must also control connectivity along with other type-specific features of neurons, the gene regulatory mechanisms that link early cell fate decisions to neuronal differentiation and circuit formation are still mostly unknown.

Research in our lab combines high throughput single-cell analyses of gene expression and chromatin accessibility (multiomics) with advanced computational modeling approaches to generate hypotheses on transcription factor function in specific neurons. These hypotheses are then immediately addressed at the bench through state-of-the-art genetic and imaging approaches.

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