06 June 2023
Investigating the placenta: Discovery from Stowers Scientists shows why this often-overlooked organ should be given more attention
We seek to understand how genome instability impacts cells, tissues, and organisms during development, female reproductive aging, and cancer.
Genetics and Genomics, Evolutionary Biology, Molecular and Cell Biology
Human cell lines, Yeast, Mice
The Gerton Lab studies chromosomes – the molecular structures made up of DNA and protein that provide the instructions for life. Defects in chromosome function underlie many human diseases such as cancer and birth defects. Using yeast and mammalian model systems as well as human cell lines and patient data, Gerton and her team are investigating groups of proteins responsible for chromosome upkeep.
One group of proteins studied in the Gerton Lab consists of the structural maintenance of chromosome (SMC) proteins. Investigation of cohesin, an SMC complex subtype has provided a wealth of information in its role in chromosome organization.
Gerton initiated and co-organizes the ASBMB special symposium “Emerging roles of the nucleolus” to bring together researchers around this topic. The lab’s research may help provide a better understanding of and potentially new treatment approaches for human conditions such as Roberts Syndrome, Cornelia de Lange Syndrome, and cancers in which cohesin function is impaired.
Gerton has identified several factors that help the kinetochore, another protein complex located on the centromere of chromosomes. Her team is investigating how the loss of chromosome cohesion and other factors impact female reproductive aging.
Stowers Institute for Medical Research
Jennifer Gerton, Ph.D., is a molecular and cellular biologist focusing on chromosome dynamics and behavior during cell division. She joined the Institute in 2002 and currently serves as an Investigator.
The Gerton Lab participated in a large international consortium working to complete the assembly of the human genome from telomere-to-telomere. She speculates some newly assembled regions of the human genome may act as phenotypic modifiers of disease states.
Investigator Jennifer Gerton has been at the Institute for 20 years. Listen as she explains why the support here makes it a great place for someone who is just starting a lab.
06 June 2023
In The News
17 May 2023
20 years after scientists finished the sequencing of the first human genome, scientists around the world — including from the Stowers Institute in Kansas City — have taken another monumental step.
10 May 2023
Collaboration with Stowers scientists reveals mechanism underlying a common chromosomal abnormality
In The News
20 January 2023
The Genetics Society of America (GSA) is excited to announce the latest cohort of student, postdoc, and early-career research leaders joining the Early Career Leadership Program.
Telomere-to-telomere assembly of a complete human X chromosome
Miga KH, Koren S, Rhie A, Vollger MR, Gershman A, Bzikadze A, Brooks S, Howe E, Porubsky D, Logsdon GA, Schneider VA, Potapova T, Wood J, Chow W, Armstrong J, Fredrickson J, Pak E, Tigyi K, Kremitzki M, Markovic C, Maduro V, Dutra A, Bouffard GG, Chang AM, Hansen NF, Wilfert AB, Thibaud-Nissen F, Schmitt AD, Belton JM, Selvaraj S, Dennis MY, Soto DC, Sahasrabudhe R, Kaya G, Quick J, Loman NJ, Holmes N, Loose M, Surti U, Risques RA, Graves Lindsay TA, Fulton R, Hall I, Paten B, Howe K, Timp W, Young A, Mullikin JC, Pevzner PA, Gerton JL, Sullivan BA, Eichler EE, Phillippy AM. Nature. 2020;585:79-84.
Persistent DNA damage and senescense in the placenta impacts developmental outcomes of embryos
Singh VP, McKinney S, Gerton JL. Dev Cell. 2020;54:333-347 e337.
Super-resolution microscopy reveals linkages between ribosomal DNA on heterologous chromosomes
Potapova TA, Unruh JR, Yu Z, Rancati G, Li H, Stampfer MR, Gerton JL. J Cell Biol. 2019;218:2492-2513.
Ribosomal DNA copy number loss and sequence variation in cancer
Xu B, Li H, Perry JM, Singh VP, Unruh J, Yu Z, Zakari M, McDowell W, Li L, Gerton JL. PLoS Genet. 2017;13:e1006771. doi: 10.1371/journal.pgen.1006771
Age-associated dysregulation of protein metabolism in the mammalian oocyte
Duncan FE, Jasti S, Paulson A, Kelsh JM, Fegley B, Gerton JL. Aging Cell. 2017;16:1381-1393.
Structural plasticity of the living kinetochore
Dhatchinamoorthy K, Shivaraju M, Lange JJ, Rubinstein B, Unruh JR, Slaughter BD, Gerton JL. J Cell Biol. 2017;216:3551-3570.