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Supporting the scientific spirit of transparency, the Stowers Institute for Medical Research makes the data underlying its scientific publications freely accessible to the scientific community. Access to original, unprocessed data allows other scientists to validate and extend findings made by Stowers researchers.


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Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche

He X, Smith SE, Chen S, Li H, Wu D, Meneses-Giles PI, Wang Y, Hembree M, Yi K, Zhao X, Guo F, Unruh JR, Maddera LE, Yu Z, Scott A, Perera A, Wang Y, Zhao C, Bae K, Box A, Haug JS, Tao F, Hu D, Hansen DM, Qian P, Saha S, Dixon D, Anant S, Zhang D, Lin EH, Sun W, Wiedemann LM, Li L. Cell Rep. 2021;36:109674.doi: 10.1016/j.celrep.2021.109674.

Inter-rhombomeric interactions reveal roles for fibroblast growth factors signaling in segmental regulation of EphA4 expression

Cambronero F, Ariza-McNaughton L, Wiedemann LM, Krumlauf R. Dev Dyn. 2020;249:354-368.

A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates

Parker HJ, De Kumar B, Green SA, Prummel KD, Hess C, Kaufman CK, Mosimann C, Wiedemann LM, Bronner ME, Krumlauf R. Nat Commun. 2019;10:1189. doi: 1110.1038/s41467-41019-09197-41468.

The sea lamprey germline genome provides insights into programmed genome rearrangement and vertebrate evolution

Smith JJ, Timoshevskaya N, Ye C, Holt C, Keinath MC, Parker HJ, Cook ME, Hess JE, Narum SR, Lamanna F, Kaessmann H, Timoshevskiy VA, Waterbury CKM, Saraceno C, Wiedemann LM, Robb SMC, Baker C, Eichler EE, Hockman D, Sauka-Spengler T, Yandell M, Krumlauf R, Elgar G, Amemiya CT. Nat Genet. 2018;50:270-277.  Publisher CorrectionNat Genet.2018;50:768.


Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution.

Smith JJ, Kuraku S, Holt C, Sauka-Spengler T, Jiang N, Campbell MS, Yandell MD, Manousaki T, Meyer A, Bloom OE, Morgan JR, Buxbaum JD, Sachidanandam R, Sims C, Garruss AS, Cook M, Krumlauf R, Wiedemann LM, Sower SA, Decatur WA, Hall JA, Amemiya CT, Saha NR, Buckley KM, Rast JP, Das S, Hirano M, McCurley N, Guo P, Rohner N, Tabin CJ, Piccinelli P, Elgar G, Ruffier M, Aken BL, Searle SM, Muffato M, Pignatelli M, Herrero J, Jones M, Brown CT, Chung-Davidson YW, Nanlohy KG, Libants SV, Yeh CY, McCauley DW, Langeland JA, Pancer Z, Fritzsch B, de Jong PJ, Zhu B, Fulton LL, Theising B, Flicek P, Bronner ME, Warren WC, Clifton SW, Wilson RK, Li W. Nat Genet. 2013;45:415-421.

Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.

Wang P, Lin C, Smith ER, Guo H, Sanderson BW, Wu M, Gogol M, Alexander T, Seidel C, Wiedemann LM, Ge K, Krumlauf R, Shilatifard A. Mol Cell Biol. 2009;29:6074-6085.

A regulatory module embedded in the coding region of Hoxa2 controls expression in rhombomere 2.

Tümpel S, Cambronero F, Sims C, Krumlauf R, Wiedemann LM. Proc Natl Acad Sci U S A.2008;105:20077-20082.

Expression of Hoxa2 in rhombomere 4 is regulated by a conserved cross-regulatory mechanism dependent upon Hoxb1

Tümpel S, Cambronero F, Ferretti E, Blasi F, Wiedemann LM, Krumlauf R. Dev Biol.2007;302:646-660.

PTEN-deficient intestinal stem cells initiate intestinal polyposis

He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L. Nat Genet.2007;39:189-198.

Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion

Zhang J, He XC, Tong WG, Johnson T, Wiedemann LM, Mishina Y, Feng JQ, Li L. Stem Cells.2006;24:2826-2839.

Evolution of cis elements in the differential expression of two Hoxa2 coparalogous genes in pufferfish (Takifugu rubripes)

Tümpel S, Cambronero F, Wiedemann LM, Krumlauf R. Proc Natl Acad Sci U S A.2006;103:5419-5424.

PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, Haug JS, Rupp D, Porter-Westpfahl KS, Wiedemann LM, Wu H, Li L. Nature. 2006;441:518-522.

Direct crossregulation between retinoic acid receptor {beta} and Hox genes during hindbrain segmentation

Serpente P, Tumpel S, Ghyselinck NB, Niederreither K, Wiedemann LM, Dolle P, Chambon P, Krumlauf R, Gould AP. Development.2005;132:503-513.

Hoxb1 enhancer and control of rhombomere 4 expression: complex interplay between PREP1-PBX1-HOXB1 binding sites

Ferretti E, Cambronero F, Tumpel S, Longobardi E, Wiedemann LM, Blasi F, Krumlauf R. Mol Cell Biol.2005;25:8541-8552.

BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling

He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, Mishina Y, Li L. Nat Genet.2004;36:1117-1121.

MLL-ENL cooperates with SCF to transform primary avian multipotent cells

Schulte CE, von Lindern M, Steinlein P, Beug H, Wiedemann LM. EMBO J. 2002;21:4297-4306.

Hox genes and segmentation of the vertebrate hindbrain.

Tumpel S, Wiedemann LM, Krumlauf R. Curr Top Dev Biol. 2009/08/05 ed; 2009;88:103-137.

CBF Beta

Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, Haug JS, Rupp D, Porter-Westpfahl KS, Wiedemann LM, Wu H, Li L. Nature.2006;441:519-522.

Identification of the haematopoietic stem cell niche and control of the niche size

Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, Ross J, Haug J, Johnson T, Feng JQ, Harri S, Wiedemann LM, Mishina Y, Li L. Nature. 2003;425:836-841

Q & A

Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, Haug JS, Rupp D, Porter-Westpfahl KS, Wiedemann LM, Wu H, Li L. Nature.2006;441:519-522.

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