The Stowers Institute for Medical Research has an opening for a Postdoctoral Researcher to address developmental neurobiology and neural circuit studies. The chosen candidate will participate in research in one or more of the following areas: the molecular mechanism of neural circuit specification, the development and plasticity of neural circuitry, and mapping of neural circuitry involved in specific behaviors. The lab employs a combination of methodologies including molecular genetics, single cell sequencing, fluorescent whole-brain imaging, optogenetic, chemicogenetic and behavioral techniques. More details, including selected publications, can be found at /labs/yulab.asp.
The candidate will enjoy intramural research support from the Stowers Institute with strong support from core facilities that provide advice, training and service to enhance the Institute's interdisciplinary and collaborative research programs. Current core facilities are staffed by over 100 scientists with expertise in bioinformatics, cytometry, histology, imaging, microarray, next generation sequencing, transgenic and ES cell technologies, proteomics and molecular biology. The Stowers Institute offers a highly competitive compensation and benefits package.
Minimum requirements include a doctoral degree in the life sciences, chemistry, or biomedical engineering. Experience in one or more of the following areas is desirable but not required: molecular biology, developmental neuroscience, genetics, immunology, electrophysiology, and imaging.
In addition to excellent verbal and written communication skills, successful candidates must be highly motivated, work independently and creatively, committed to a scientific career, ability to work in a team-oriented environment, and proficient at problem solving.
The Stowers Institute has an opening for a Programmer Analyst to assist Computational Biology core with programming tasks. and data analysis.
The programmer analyst will develop and support Next-generation sequencing informatics processes, maintain and optimize the current NGS primary and secondary analysis pipeline, and provide bioinformatics support to research projects by using computational tools to process, transform, visualize, and analyze datasets primarily derived from high-throughput sequencing. The individual will also involve scientific software support.
Minimum requirements include an undergraduate degree in Computer Science or a related discipline. Individuals with a Master's degree in computer science with a bioinformatics concentration or a Master's degree in bioinformatics with solid computer programming skills are encouraged to apply. We require proficiency with at least one scripting language (Perl, Python, or Ruby) as well as experience working in a Unix/Linux environment. Experiences in cluster computing (i.e. Sun Grid Engine) and R/Bioconductor are desired but not essential.
In addition to outstanding communication and organization skills, the successful candidate will have strong problem-solving abilities, good time management skills, and the ability to multi-task in a team-oriented environment.
Application Instructions: To apply, please submit a current resume and 2 letters of recommendation to firstname.lastname@example.org or to Administration Department, Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110.
The Stowers Institute for Medical Research has an opening for a Research Technician in the Screening core facility to perform high throughput production of lentivirus and adenovirus as well as perform cell-based viral-mediated screens.
Responsibilities include cloning cDNA, Cas9 and CRISPR guides into lentiviral and adenoviral vectors; high-throughput production of lentivirus and curation of viral libraries; optimization of viral production, viral titration, and MOI transduction of mammalian cells; utilization of robotic platforms for viral production, transduction of cells for screening and hitpicking for validation and counterscreens; generation of high titer bulk virus; and screening of stable mammalian cell lines transduced with virus.
In addition to excellent communication skills and the ability to work in a team-oriented environment, the successful candidate will have an attention to detail, strong leadership skills, ability to embrace working with technology/robots, mastery of tissue culture and transfection or transduction of mammalian or non-mammalian cells; prior experience with PCR, cloning, and other molecular biology techniques; and experience with lentiviral and/or adenoviral production.
Minimum requirements include an undergraduate degree in biology, microbiology, biochemistry or a related field with at least 4 to 7 years of related laboratory experience, or a Master’s degree in biology, microbiology, biochemistry or a related field with 2 to 3 years of related laboratory experience. Additional preferred skills include robotic experience with one or more robotic systems, programming and troubleshooting of robotic instrumentation, biological readouts in microtiter formats, assay development and screening in microtiter format, CRISPR assay development and screening; experience with cell-based reporter assay systems or screening small molecules; experience in high content imaging; bioinformatics experience; and proficiency with Microsoft Excel, Prism and Spotfire software.
Application Instructions: To apply, please submit a current resume, 2 letters of recommendation, and transcripts to email@example.com or to Administration Department, Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110.