Past Wednesday Lectures
May 30, 2018
Regulatory evolution and the diversification of pigmentation patterns in Drosophila
May 23, 2018
Yeast aging as a model for understanding genomic immunity in eukaryotes
May 16, 2018
Virology meets Proteomics: Defining proteome organization and host defense mechanisms during viral infection
May 9, 2018
Seeing is believing: mechanism for genome maintenance
May 2, 2018
Defects in mRNA translation and neurological disease
April 25, 2018
Deciphering the regulatory codes shaping the maternal to zygotic transition during development
April 18, 2018
Building a spindle and segregating chromosomes without centrosomes: Oocyte meiosis in C. elegans
April 4, 2018
Metabolic Control of Mammalian Embryonic Development
March 21, 2018
Genomic and epigenetic variation controls human centromere function
March 14, 2018
Elucidating lung stems cells and cancer initiation at single cell resolution
March 7, 2018
Induction and lineage in vertebrate development: insights from zebrafish
February 21, 2018
Breaking PAR: Sex chromosome recombination in mouse male meiosis
January 31, 2018
Designing peptides to manipulate Bel02 protein control of cell death
January 24, 2018
Correlative Microscopy in Studies of Disease Pathogenesis
January 17, 2018
Sex chromosomes, chromatin sinks & sex-specific development & aging
November 29, 2017
Induction of pluripotent and multipotent stem cells
November 15, 2017
The Causes and Consequences of Aneuploidy.
November 8, 2017
Developing Hedgehog Pathway Inhibitors to Treat Pediatric Brain Tumors: How Basic Science Drives Translation
November 1, 2017
The establishment of chromatin domains in normal development and in cancer
October 25, 2017
Evolution and Development: Insights from Emerging Model Systems
October 18, 2017
Flying Wounded: Using Drosophila to study tissue repair responses
October 11, 2017
A Car Accident, High Bone Mass and Muscle-Bone Crosstalk
October 4, 2017
Scratching beneath the surface of transcription factor-DNA recognition
September 27, 2017
From Petabytes to Molecular Insights: Building an Operating System for Cancer
September 20, 2017
Bringing light into dark, how cavefish illuminate medicine and evolution
September 13, 2017
Metabolic Impact of Unrestrained Transcription by RNA Polymerase III
September 6, 2017
Historical Development and Cellular Regulation of CRISPR-based Gene Editing in Human Cells
May 24, 2017
Genomic revolutions: Antarctic fish and the teleost genome duplication
May 17, 2017
Alternative model organisms: new tools, new insights into the evolution of development
May 10, 2017
Translational Control of Neurologic Disease
April 26, 2017
The gene regulatory logic of vertebrate neural tube development
April 19, 2017
DNA Replication Licensing in Genome Stability and Cancer
April 12, 2017
Uncoupling the evolution of morphology and regulatory networks during the evolution of nervous systems
April 5, 2017
In Situ Structural Biology: Expansion, Super-resolution, and Image averaging
March 29, 2017
Controlling the volume of gene expression with CRISPRi and CRISPRa
March 22, 2017
Centrosomes in Development, Evolution and Disease
March 15, 2017
Regulating exit from the stem cell compartment in mammalian epidermis
March 1, 2017
Epigenetic Allelic Effects and Computational Ethology: New Paradigms in Behavioral Genetics
February 22, 2017
Actuating memory: how C. elegans remembers a learned behavioral preference
February 15, 2017
Genomics of adaptations and speciation in the repeated adaptive radiation of cichlid fish
February 1, 2017
Saving the Synapse: developmental critical periods and Alzheimer's disease
January 25, 2017
Physical Mechanisms of Cell Organization on Micron Length Scales
January 18, 2017
Interconnections Between Ribosome Activity and mRNA Decay
January 11, 2017
Hidden regulatory code within the genetic code
January 4, 2017
Knocking out circular RNAs and reconstructing embryos from single cell sequencing
December 14, 2016
Precision medicine for breast cancer: PARP inhibitor and immune checkpoint threapy
November 30, 2016
A Developmental Achille's Heel: Genetic Analysis of Mechanotransduction in Tendon Development
November 16, 2016
Studying the genotype to phenotype connection from an evolutionary perspective
November 9, 2016
Planar cell polarity, ciliogenesis, and human disease
November 2, 2016
Intra-Tumoral heterogeneity in small cell lung cancer
October 26, 2016
Maternal and zygotic genetics in the evolution of animal development
October 19, 2016
Digging for genes that affect behavior in wild mice
October 12, 2016
Mitotic regulators in chromosome segregation and insulin signaling
October 5, 2016
Close Reading of Enhancers: Lessons from Drosophila
September 21, 2016
Putting Your Inner Fish to Work in the Genome
September 14, 2016
Epigenetic genome control by heterochromatin and RNA processing factors
September 7, 2016
Collective migration of neural crest cells
June 30, 2016
May 18, 2016
Signals and forces that control the dynamics of multicellular systems
May 11, 2016
Insulin signaling, Cognitive Decline, and Reproductive Aging: Quantifying Quality of Life
April 27, 2016
Quantitative Proteomics for Understanding Modified Proteins and Proteomes
April 20, 2016
Therapeutic targeting of Myelodysplastic syndromes and acute myeloid leukemia
March 23, 2016
Synapse elimination and reorganization of corticospinal circuits underlying skilled movements
March 9, 2016
Dynamin and the Regulation of Clathrin-Mediated Endocytosis
December 2, 2015
Genetic lineage tracing of the myofibroblast in the mouse
November 18, 2015
Cryo-EM: An atomic resolution window into Mediator and transcription initiation
November 11, 2015
From Protein Folding to Cognition: The Serendipitous Path of Discovery
November 4, 2015
Nuclear Architecture and Genome Stability
October 28, 2015
Competitive Repopulation of the Stem Cell Niche in AML: Implications for Blood Stem Cell Transplantation
October 21, 2015
X-chromosome inactivation, color vision, and the female advantage
September 30, 2015
21st century genetics: mass Spectrometry of yeast telomerase
September 23, 2015
Potential Role of Extracellular Tau in Development and Spread of Tauopathy: Effects of Anti-Tau Antibodies
September 16, 2015
Understanding animal origins: epithelial morphogenesis in the sea anemone, Nematostella vectensis
September 9, 2015
Surprises from Single Cell Analysis of Mouse and Human Cells
June 3, 2015
Making blood: the organized labor of multiple niches
May 27, 2015
Control of self-renewal in hemopoietic precursor cells
May 6, 2015
BMP signallng and cell fate specification in Drosophila
April 15, 2015
Signaling networks in health and disease: a tale of Hippos and mulberries
April 1, 2015
Spatial and temporal trajectories in the developing inner ear resolved with single cell gene expression analysis
March 11, 2015
Spatial control of tissue mechanics during morphogenesis
March 4, 2015
An Unexpected Journey: The Lysine Methylome, Epigenetic Signaling and Disease
January 21, 2015
Transcriptional regulation of cardiac lineages
November 19, 2014
Germ cell development and regeneration in planarians: implications for understanding parasitic flatworms
November 12, 2014
Shaping the eukaryotic transcriptome with chromatin and ncRNA transcription
November 5, 2014
Autophagy: Staying in for Dinner
October 29, 2014
Cold-blooded cancer and Elongating Eggs: Epithelia Function in Development and Disease
October 15, 2014
Amyloid-mediated translational control is required for meiosis
October 1, 2014
Genomic organization of chromatin and the transcription machinery
September 17, 2014
The microenvironmental niches for hematopoietic stem and progenitor cells in bone marrow
September 10, 2014
Personalized Medicine: Personal Omics Profiling During Healthy and Disease States
September 3, 2014
The wonderful worlds of hybrids
May 28, 2014
Life and death in the lateral line: zebrafish models for hearing loss
May 21, 2014
An expanding job description for the transcriptional repressor Blimp1/Prdm1 in the developing mouse embryo
May 14, 2014
Mechanisms of contact-induced cell polarity in the C. elegans embryo
May 7, 2014
Why do transcriptional enhancers contain clusters of homotypic transcription factor binding sites?
April 23, 2014
Mechanisms of mitosis and size control in Xenopus
April 16, 2014
Coordinating mitosis and morphogenesis in proliferating epithelia
April 9, 2014
Endless pigeons most beautiful: evolutionary genomics of Darwin's favorite birds
April 2, 2014
Dynamics of histone variants at yeast promoters and centromeres
March 26, 2014
Punctilious Probing of Promoters and Prenucleosomes
March 19, 2014
Wolbachia, African Riverblindness and Big Sur
March 5, 2014
Building an adaptive genome defense system
February 19, 2014
Using RNA-Seq methods for single cells and other challenging samples
February 12, 2014
The St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project: Lessons learned
February 5, 2014
Genetic Conflicts Shape Centromeres and Species
January 29, 2014
Chemical Modulation of Chromatin Structure and Function
January 15, 2014
Orienting Chromosomes on the Meiotic Spindle
January 8, 2014
Molecular, cellular and circuit mechanisms of memory allocation
December 11, 2013
Dendritic integration, plasticity, and diversity in hippocampal pyramidal neurons
December 4, 2013
Spatiodynamics of clathrin-mediated endocytosis in yeast and mammals
November 20, 2013
Autophagy: Staying in for Dinner?
November 13, 2013
DNA and RNA binding motifs for mapping gene regulation
November 6, 2013
Electron Cryomicroscopy: From Molecules to Cells
October 30, 2013
Pathways and Mechanisms of Hematopoietic Lineage Commitment
October 23, 2013
Food for Thought: nutrients and neural stem cells in Drosophila
October 16, 2013
Cellular and Molecular Specializations in Sensory Development and Function
October 9, 2013
The Ins and Outs of the Eukaryotic Nucleus
October 2, 2013
Mechanisms and Functions of Nrf2 Signaling: Stress Defense, Aging, Stem Cells
September 25, 2013
How Long Lasting Memories Are Formed
September 18, 2013
Mechanism and Regulation of RNA Polymerase II
September 4, 2013
Modeling Animal Transcription Networks During Development
May 29, 2013
Zebrafish facial branchiomotor neuron migration: pioneers, followers and those than need guidance
May 22, 2013
Cell recognition and the Assembly of Neural Circuits
May 15, 2013
Roles and mechanisms of boundary formation
May 1, 2013
Molecular mechanisms of olfactory receptor gene choice
April 24, 2013
Motility and Directed Migration of Primordial Germ Cells in Zebrafish
April 17, 2013
High-throughput genetic screens to define mechanisms of human neurodegenerative disease
April 10, 2013
Patterns of Gene Expression in Development and Evolution
April 3, 2013
Transcriptional precision in the Drosophila embryo and evolutionary origins of the neural crest in the Ciona tadpole
March 27, 2013
Structural, Molecular and Cellular Mechanism that underlie Transcription Faction function
March 20, 2013
Regulatory genomics - decoding Drosophila regulatory sequences
March 13, 2013
Mechanical Pathways of Cell Polarization and Motility Initiation
March 6, 2013
Rho GTPases: Physiologic Functions and Translational Implications
February 27, 2013
Pathways and Mechanisms of Hematopoietic Lineage Commitment
February 13, 2013
Development and Organization of Neurons that Underlie the Sense of Touch
February 6, 2013
Development and Organization of Neurons that Underlie the Sense of Touch
January 30, 2013
Rewiring the p53 Network for Effective Cancer Therapies
January 23, 2013
Chromatin regulation and the landscape of RNA polymerase II transcription in C. elegans.
January 9, 2013
Chromatin modifications: Their function and role in cancer
December 12, 2012
Transcriptional Control of Cortical Interneuron Development
December 5, 2012
Split decisions: Regulating the end of the cell cycle
November 14, 2012
Novel intracellular stress and stress response in budding yeast
November 7, 2012
Characterization and Targeting of Leukemia Stem Cells
October 24, 2012
Licensed to Elongate: Transcriptional Elongation Checkpoint Control in Development and Leukemogenesis
October 17, 2012
Development and Evolution of Form in the Vertebrate Limb
October 10, 2012
How the Turtle Gets Its Shell: The Developmental Basis of Evolutionary Novelty
October 3, 2012
Stem Cells, Pluripotency And Nuclear Reprogramming
September 19, 2012
Epigenetic Mechanisms of Cell Lineage Specification in Development and Disease
September 12, 2012
Regulation of cell fates and movements during zebrafish gastrulation
September 5, 2012
Genomewide Dissection of Complex Trait Variation in Drosophila
June 6, 2012
A history of germ cell migration: from there to here
May 30, 2012
MiR-181a mediates the control of embryonic stem cell self-renewal
May 25, 2012
Morphogenesis and differentiation in the developing circulatory system
May 24, 2012
Structure and Stability of Genome
May 23, 2012
Gene Regulatory Networks
May 19, 2012
Histone Variant Dynamics and Epigenetics
May 16, 2012
Visualizing Complex Events in the Embryo
May 9, 2012
Unexpected regulators of metabolic stress
May 2, 2012
Regulation of telomerase at chromosome ends
April 18, 2012
Sleep circuits in Drosophila melanogaster
April 11, 2012
Making and protecting the germline
March 28, 2012
The hungry fly: From molecules to circuits and olfactory behavior
March 21, 2012
The Hole Picture: Architecture and Mechanism of the Nuclear Pore Complex
March 14, 2012
How do cells get the right chromosomes?
March 7, 2012
New Parts from Old: The Problem of Regeneration
February 29, 2012
Cholinergic modulation of cortico-limbic circuits and behaviors
February 22, 2012
ERKonomics of nutrient sensing
February 15, 2012
Transport vesicle biogenesis: Lessons from yeast applied to mammalian development
February 8, 2012
Nuclear function of methionine adenosyltransferase in gene regulation and histone methylation
February 1, 2012
New Advances Molecular Pathogenesis and Pathway Dependence in T-cell ALL
January 25, 2012
Gene regulatory interactions in neural crest development
January 18, 2012
Roles of Mcd1 sumoylatioin and proteolytic cleavage during DSB repair
January 11, 2012
Organizing microtubule organizers
December 14, 2011
Mother knows best: developmental plasticity during gut formation
December 7, 2011
Using Biointelligence to Search the Cancer Genome: Knowledge Recovery Efforts to Move Towards Precision Medical Genomics (PMG)
November 30, 2011
Telomeres as choreographers of chromosome replication, location and segregation
November 16, 2011
Deploying zebrafish to understand heart regeneration
November 9, 2011
What do you need to make a muscle?
The role of muscle stem cells and connective tissue fibroblasts in muscle development and regeneration
November 2, 2011
Metabolic Flexibility and Suspended Animation
October 26, 2011
Generation of temporal identity in the Drosophila CNS
October 19, 2011
New strategies for decoding genomes
October 12, 2011
The zebrafish lateral line as a model to study morphogenesis and regeneration
October 5, 2011
Embryos start your engines: Initiating and regulating transcription in the early Drosophila embryo
September 28, 2011
Decoding transcription: Genomic and computational approaches in Drosophila
September 21, 2011
Evolution of Axial Development and Regeneration: Insights from the Lizard Anolis Carolinensis
September 14, 2011
Pheromone Signaling in C. elegans: Mechanisms and Consequences
September 7, 2011
Transcriptional networks in flies and humans: predicting drug targets and patient outcomes
May 25, 2011
Strategies for Organising Chromogenomes
May 18, 2011
Creating Intimacy: Chromosomal Connections for Gene Expression and Crossovers
May 11, 2011
Making CENs of Heterochromatin: rebooting and programming centromeres
May 4, 2011
Synergy Between NMR and cryoEM - Novel Findings for HIV Capsid Function
April 27, 2011
The Ploidy Conveyor of Mature Hepatocytes as a Source of Genetic Variation
April 20, 2011
Oncogene-mediated Engagement of the ARF-p53 Tumor Suppressor Network
April 13, 2011
Telomerase, Stem Cells and Wnt Signaling
April 6, 2011
Predicting Protein-Protein Interactions from the Genome for Evolutionary Analysis
March 30, 2011
The Lipodystrophy Proteins Lipin And Seipin Control Lipid Droplet Assembly
March 23, 2011
A Misregulated Genome is a Wild, Crazy and Largely Decipherable Place: Stories from Yeast
March 9, 2011
Emerging Fluorescence Technology for Analysis of Protein Localization and Organelle Dynamics
March 2, 2011
Genome dynamics in Candida Albicans
February 23, 2011
Managing Mitosis and Differentiation, Lessons from Yeast Mating
February 16, 2011
Chromatin and Gene Expression: Beyond Histone Modifications and Transcription Initiation
February 9, 2011
ORC, the Initiator for DNA Replication, Coordinates Chromosome Segregation During Mitosis at Centromeres and Centrosomes
January 26, 2011
Wnt-Dependent Patterning and Homeostasis in Developing Epithelia
January 19, 2011
Telomeres and Telomerase – all is well that ends well
January 12, 2011
Planar Cell Polarity: From cell biology to human disease
December 15, 2010
Cell Fate Determination in the Vertebrate Retina
December 8, 2010
Optical Imaging of Memory Formation in Drosophila
December 1, 2010
Competition by Design: The Ongoing Battle between Paused Pol II and Nucleosomes for Promoter Occupancy
November 17, 2010
Epigenetic Inheritance of Transcriptional States
November 10, 2010
Understanding Meiotic Recombination Using Arabidopsis Tetrads
November 3, 2010
Growth, Death and Regeneration: Studies in Drosophila
October 27, 2010
A Role For The Mediator Of RNA Polymerase Ii Transcription In Elongation Control
October 20, 2010
How does Cancer Chemotherapy Directed at Dividing Cells Really Work?
October 13, 2010
Current And Future Preventive HPV Vaccines Against Cervical Cancer And Other HPV-Associated Disease
October 6, 2010
Genetic Manipulations in the Fruit Fly Fight Club: Sex and War in a Single Gene and Other Stories
September 29, 2010
Neural Map Formation in the Mouse Olfactory System
September 22, 2010
Protein Complexes that Modify Chromatin for Transcription
September 15, 2010
Evolution of Genetic Networks Underlying the Emergence of Vertebrate Neural Crest: Insights from Amphioxus
September 8, 2010
Breaking Symmetry: Polarization of the C. elegans Embryo
May 26, 2010
Metabolites Connect Cellular Signaling to Chromatin Dynamics
May 19, 2010
Histone Variant Dynamics and Epigenetics
May 12, 2010
mRNA Processing: Links to Disease and Other Cellular Processes
May 5, 2010
Using C. elegans to Dissect Cell Division Mechanisms
April 28, 2010
Getting In and Out of Mitosis
April 21, 2010
Dynamics and Functional Associations of JMJD3, an H3K27 Demethylase
April 14, 2010
Skin-derived Precursors: From Morphogenesis to Repair
April 7, 2010
A Bum’s Up View of Metazoan Body Plan Evolution
March 31, 2010
Resistance to Ribosome-targeting Antibiotics Conferred by Changes in rRNA Methylation
March 24, 2010
Targeting a Novel Embryonic Pathway to Suppress the Metastatic Phenotype
March 17, 2010
Sex, Flies and Videotapes
March 10, 2010
Microenvironments of Metastasis: Insights Derived by Multiphoton Imaging
March 3, 2010
The Mechanics of Cell Shape Change in Drosophila Embryos
February 24, 2010
Regulatory Genomics and Epigenomics in Fly and Human
February 17, 2010
Cadherins and Catenins in Development and Cancer
February 3, 2010
Transcriptional Control of Cardiovascular Development
January 27, 2010
Defining Functional Pathways, Systems, and Networks to Link Genes to Traits and Diseases
January 20, 2010
Deciphering Biology and Disease by Large-scale Genetic Screens in Flies and Mammals
January 13, 2010
Zelda, a Key Activator of the Early Zygotic Genome in Drosophila
December 9, 2009
Epigenomic Studies of Normal and Malignant Stem Cells
December 2, 2009
Gene Regulatory Mechanisms Controlling Left/Right Asymmetry in the Nervous System of C. elegans
November 18, 2009
Cross-talk between Cell Adhesion Complexes in the Control of Morphogenetic Cell Movements
November 11, 2009
Cellular Construction of a Protein Machine: Chaperone-assisted Proteasome Assembly
November 4, 2009
Viewing the Chromatin of Dying Cells through the Lens of Top-Down Mass Spectrometry
October 28, 2009
Skin Stem Cells in Morphogenesis and Cancer
October 21, 2009
Mouse Embryonic Stem Cells Exist in a Unique, Threonine-dependent Metabolic State
October 14, 2009
Exploring Gene Regulation through Chemistry and Genomics
October 7, 2009
Cholesterol Homeostasis and Sterol-accelerated Degradation of HMG CoA Reductase
September 30, 2009
Shaping the Fission Yeast Cell
September 23, 2009
Chromatin Remodeling and the Transcriptional Regulation of Heart Development
September 16, 2009
Gene Regulation from a Distance
September 9, 2009
Notch Signaling in Hematopoietic Stem Cells: Basic Findings and Clinical Implications
May 20, 2009
The Role of the Rb Family in Retinal Development and Retinoblastoma
May 6, 2009
Life, Death, and Transformation: Repeats, ncRNAs, and Architectural Strategies
April 29, 2009
Chromatin Signatures of Transcriptional Enhancers
April 22, 2009
The Virtual Cell Project
April 15, 2009
Making the Blastocyst: Early Lineage Development in the Mouse
April 8, 2009
Connecting Inductive Signals to Epigenetics during Endoderm Differentiation
April 1, 2009
Host-microbe Relationships in the Zebrafish Digestive Tract
March 25, 2009
Harnessing Phage Integrases for Gene Therapy and Cell Therapy
March 18, 2009
Gut Homeostasis Mediated by Drosophila Intestinal Stem Cells
March 11, 2009
Molecular Genetics of Vertebrate Dorsal-Ventral Limb Patterning
March 4, 2009
Posttranslational Modifications as Regulators of Chromatin Structure and Histone Chaperone Function
February 25, 2009
Finishing the Cell Cycle
February 18, 2009
Spliceosome Dynamics and Their Impact on the Fidelity of Splice Site Selection
February 11, 2009
Growth Cone Guidance Receptors and the Pathogenesis of ALS/Lou Gehrig’s Disease
February 4, 2009
Embryonic Stem Cells: Building Alternative Pluripotency Networks
January 28, 2009
Legacy of Science: Rare Books in Kansas City’s Linda Hall Library
January 21, 2009
The von Hippel-Lindau Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer
January 14, 2009
HMMR: A New Generation of Homology Search Software
December 10, 2008
Self-renewal and Differentiation in the Drosophila Nervous System
December 2, 2008
Dying Young as Late as Possible: Planarians, Regeneration, and Stem Cells
November 19, 2008
Mobile Group II Introns: Site-specific Integration into DNA and Applications in Gene Targeting
November 12, 2008
Stem Cell Renewal and Differentiation in Mammalian Epidermis
November 5, 2008
Stem Cell Transcriptional Circuitry and Reprogramming
October 29, 2008
Modeling Disease with Human Pluripotent Cells
October 22, 2008
Exploring Mechanisms of Telomere Length Regulation
October 15, 2008
Getting to the Root of Developmental Networks
October 8, 2008
Specification and Reprogramming of Germ Layer Identity in C. elegans Embryos
October 1, 2008
Translational R & D at BioMed Valley Discoveries
September 24, 2008
Stem Cells and T Cells: Optimizing Allogeneic Stem Cell Transplantation
September 17, 2008
The Developmental Genetic Origins of Cortical Interneurons
September 10, 2008
The Machines that Divide and Fuse Mitochondria
May 21, 2008
Evolving Therapeutic Targets for Lysosomal Storage Diseases
May 14, 2008
The Cell Biology of snRNP Biogenesis
May 7, 2008
Synaptic Signaling in C. elegans: MicroRNAs and Seizures
April 30, 2008
Assembling a Circuit for Olfactory Behavior
April 23, 2008
Processing Spatial Information in the Mitotic Spindle
April 16, 2008
How Proteins Find their Target Sites in vivo: Implications for Epigenetic Inheritance
April 9, 2008
Pancreatic Stem Cells for Development and Diabetes
April 2, 2008
Customized Pluripotent Stem Cells
March 28, 2008
The Battle of the Sexes: Patterning the Gonads
March 19, 2008
Non-random Segmentation of Sister Chromatids
March 12, 2008
Steroid Receptor Mediated Transcriptional Activation within Chromatin
March 5, 2008
Feast to Famine: Nuclear Receptor Control of Metabolism
February 27, 2008
Cell Cycle Regulation and the DNA Damage Checkpoint
February 20, 2008
Shaping and Misshaping the Nucleus
February 13, 2008
Unbiased Biology: Functional Insights from Protein-Protein and Genetic Interaction Datasets
February 6, 2008
Oncogenic Properties of Alternative Splicing Factors
January 30, 2008
BMP Antagonists in Vertebrate Development
January 23, 2008
Dynamics of Cell Polarization in the Early C. elegans Embryo
January 16, 2008
The Ins and Outs of Chromosome Cohesion
January 9, 2008
Elucidation of Pathological Interactions among the Egfr/Erbb Gene Family Using Mouse Models
December 12, 2007
Homology-directed Genetic Surveillance Mechanisms
December 5, 2007
Regulation of Wnt Signaling at the Plasma Membrane
November 28, 2007
BRUCE: An Inhibitor of Apoptosis Functions in a Non-apoptosis Pathway
November 14, 2007
Networks and Pathways of Lysine Modification
November 7, 2007
Dynamic Cortical Rearrangements and Mechanosensing during Cell Division
October 31, 2007
Genome-wide Interactions of Nuclear Receptors with Chromatin
October 24, 2007
Spatial Regulation of Bacterial Cytokinesis
October 16, 2007
Studies on Experimental Evolution in Budding Yeast
October 10, 2007
Asymmetric Cell Division and Stem Cell Homeostasis
October 3, 2007
Matrix Metalloproteinase-1 Acts as a Brownian Ratchet
September 26, 2007
Molecular Basis of Default and Stemness in Human Embryonic Stem Cells
September 19, 2007
Growth Control Mechanisms Revealed by the Zebrafish Fin
September 12, 2007
Circadian Gene Expression: Communication between Central and Peripheral Oscillators
September 5, 2007
Genetic and Molecular Characterization of the Human Circadian Clock
May 30, 2007
The Blood and Guts of Cancer Stem Cells
May 23, 2007
DNA Damage Responses: Mechanisms and Consequences of Failure
May 16, 2007
Cartography Representation of Cellular Processes
May 9, 2007
Apoptosis and Mitochondria: The Roads to Ruin
May 2, 2007
Quantitative Analysis of Developmental Signaling Pathways
April 25, 2007
Detection and Processing of Color Information (in Drosophila)
April 18, 2007
Defining Intrinsic Tumor Suppression Pathways in Cancer
April 11, 2007
The Spatial Organization of Repair and Transcription
April 4, 2007
Analyzing Synapse Formation with Mutant and Fluorescent Mice
March 28, 2007
Insights into Programmed Cell Death by Structural Biology
March 21, 2007
Tracking Transcription Factor Recruitment Dynamics, and Function at Specific Inducible Genes in vivo and in Real Time
March 12, 2007
Engineering Chromosomes to Study Large-scale Gene Regulation during Vertebrate Development
March 7, 2007
Imaging and Biochemistry of Cytokinesis
February 28, 2007
Cellular and Molecular Mechanisms Regulating the Development of the Lymphatic Vasculature in Health and Disease
February 21, 2007
Linage Specific Differentiation of ES Cells in Culture
February 14, 2007
Identification of Intact Proteins, Large Peptides, and their Post-translational Modifications on a Chromatographic Time-scale by Using a Combination of Ion/Ion Chemistry and Tandem Mass Spectrometry
February 7, 2007
Chromatin Remodeling Machines: Regulators of Transcription and DNA Repair
January 31, 2007
In vivo Functions of Histone Modifying Enzymes
January 24, 2007
Non-coding RNA, Chromatin, and Fate Decisions in Embryonic Stem Cells
January 17, 2007
Control of the Cell Division by Proteolysis and the Primary Cilium
January 10, 2007
Death by Design: Mechanism and Regulation of Apoptosis
December 13, 2006
Patterning the Embryo: From Organizing Centers to Organizing Fields (How to Build an Embryo with Morphogens)
December 6, 2006
How are CNS Synapses Eliminated?
November 29, 2006
Proteolysis of MLL Family Proteins is Essential for Taspase1-orchestrated Cell Cycle Progression
November 15, 2006
Functional Proteomics for Biomarker and Target Discovery
November 8, 2006
Location Proteomics: A Systems Biology Approach to Subcellular Location
November 1, 2006
MN1, a New Player in Human Acute Myeloid Leukemia
October 25, 2006
Fluctuations and the Cell Cycle in Budding Yeast
October 18, 2006
Meiotic DNA Double-strand Break Repair in Mice and Humans
October 11, 2006
RNAi and Other Ancient Pathways Programmed by Small RNAs
October 4, 2006
Cracking the (epi)Proteome Code: Adventures in Proteomics
September 27, 2006
The Neural Crest, a Pluripotent Structure of the Vertebrate Embryo: Developmental and Evolutionary Aspects
September 20, 2006
Centrosomes in a Ciliate? The Tetrahymena Basal Body
September 13, 2006
Genetic Regulation of Gastrulation Movements in Zebrafish
September 6, 2006
Defective DNA Break Repair and Relationship to Human Disease
May 17, 2006
Gene Expression Cascades in Pancreas Development
May 10, 2006
Cell Signaling and Transcription Factor Control of Pituitary Cell Fate
May 3, 2006
Perturbing and Rebuilding Nuclear Networks
April 26, 2006
Aging and Cancer: Are Telomeres and Telomerase the Connection?
April 19, 2006
Stem Cell Self-renewal and Cancer
April 12, 2006
Toward a Genetic Blueprint of Cardiovascular Development
April 5, 2006
The Epigenome in the Context of the Post-Genomic Era
March 29, 2006
Modeling Tumors in the Nervous System in Mice
March 15, 2006
Mechanisms of Transcriptional Control and Disease
March 8, 2006
Nuclear Import and Export: The Rules and the Players
March 1, 2006
Analysis of Factors that Control Transcription and Chromatin Structure in Yeast
February 22, 2006
Factor and Histone Covalent Modifications in Genome Regulation
February 21, 2006
Eukaryotic Gene Transcription
February 15, 2006
Diabetic Yeasts: Glucose Sensing and Signaling by a Eukaryotic Cell
February 8, 2006
Craniofacial Development: Unmasking the Origins of Congenital Birth Defects
February 1, 2006
Building the Zebrafish Heart: From Progenitor Selection to Chamber Expansion
January 25, 2006
Coordinating Chromosome Segregation
January 18, 2006
Routes to Specificity within the ETS Family of Transcription Factors
January 11, 2006
Control of Translation and mRNA Degradation in Eukaryotic Cells
December 14, 2005
Drug Discovery in Academia: Opportunities and Challenges
December 7, 2005
Molecular Mechanisms of Temperature Sensation
November 30, 2005
Function of Polycomb Group Proteins in Mouse Development
November 16, 2005
Transcription Induction Mechanisms in Human Disease: Insights from Wnt, Notch, and HIV-1 Tat
November 9, 2005
How to Hold on to your Partner: Studies of a Simple Meiotic System
November 2, 2005
Exploring Neural Circuit Organization and Assembly Using Genetic Mosaics in Flies and Mice
October 26, 2005
Stem Cells and Systems Biology
October 20, 2005
Using RNAi to Study Itself
October 12, 2005
Control of Actin Filament Dynamics during Cytokinesis and Cellular Motility
October 5, 2005
Structural Basis of Actin Cytoskeleton Dynamics
September 28, 2005
Computational Analysis of Gene Expression and Regulation in ES Cells
September 21, 2005
Grand Challenges in Global Health
September 14, 2005
Sleep, Waking, and Attention in Drosophila
September 7, 2005
Global Analysis of Splicing Regulation
May 18, 2005
Nuclear Cloning, Stem Cells, and Epigenetic Reprogramming
May 11, 2005
Analysis of the Budding Yeast Proteome
May 4, 2005
Cyclooxygenases and the Molecular Basis of the Actions of Essential Fatty Acids
April 27, 2005
Epithelial-Mesenchymal Transformations: The Signaling Mechanisms that Create Them and the Important Roles They Play in the Embryo
April 20, 2005
Proteomic Mass Spectrometry
April 13, 2005
The High Resolution Revolution in Light Microscopy: New Insights into Anaphase Chromosome Structure
April 6, 2005
Global Mapping of the Yeast Genetic Interaction Network
March 30, 2005
Developmental Interactions in the Brainstem Auditory Pathways
March 23, 2005
Protection and Maintenance of Human Telomeres
March 16, 2005
Chromatin Boundaries, Chromatin Domains, and Gene Expression
March 9, 2005
‘Tis Death That Makes Life Live
March 2, 2005
Regulating Cell Death and Cell Differentiation in Drosophila
February 23, 2005
Head Mesoderm-Neural Crest Interactions: A Story of Victims and Bullies?
February 16, 2005
Ephrin Signaling
February 9, 2005
How are the Differences Between Males and Females Initiated During Mammalian Development
February 2, 2005
A Complex Business: Uridine Insertion/Deletion RNA Editing in Trypanosome Mitochondria
January 19, 2005
Repairing the Damaged Cord: From Stem Cell to Activity-based Mechanisms of Recovery
January 12, 2005
Signals Patterning the Developing Limb
December 8, 2004
Regulation of Nodal Signaling in Mouse Embryogenesis
December 1, 2004
Recruitment and Function of Cofactors in Transcriptional Activation by GCN4
November 17, 2004
Notch Signaling in Mice
November 10, 2004
Molecular Analysis of Breast Neoplasia
November 3, 2004
Glyceroneogenesis Revisited
October 27, 2004
Maternal Governance of Embryogenesis in Mammals: Genetic Models of the Signaling Interface between Germ Line and Soma
October 20, 2004
Recoding: Programmed Changes in Decoding
October 13, 2004
T-Box Genes in Mouse Development
October 6, 2004
Information Technology and Behavior
September 29, 2004
DNA Replication and Latency in Herpes Viruses
September 22, 2004
The Role of GDNF/Ret Signaling in Branching Morphogenesis during Kidney Development
September 8, 2004
Biochemical Studies of Apoptosis
June 2, 2004
Apoptosis Mechanisms
May 26, 2004
Making Mesoderm in the Frog
May 19, 2004
Defining the Signaling Specificity of Receptor Tyrosine Kinase Signaling
May 12, 2004
Controls of Germline Stem Cells in C. elegans
April 28, 2004
The Control of Hox Specificity: New Cofactors Among Old Friends
April 21, 2004
Molecular Control of Stem Cell Fate Determination in the Central and Peripheral Nervous System
April 7, 2004
Transcriptional Regulation of Cell Fates and Gene Expression in the Immune System
March 31, 2004
Understanding Vertebrate Limb and Neural Development Using a Multifaceted Approach
March 24, 2004
Functional Analysis of Complexes that Regulate Chromatin Structure and Transcriptional Memory
March 17, 2004
Beauty is Skin Deep: The Biology of the Epidermis and Hair Follicles
March 10, 2004
Organizing Centers and Compartments Pattern the Nervous System
March 3, 2004
The Forkhead Transcription Factors in the Control of Apoptosis, Resistance to Stress, and Organismal Longevity
February 25, 2004
BMP Signaling and Adult Stem Cell Development
February 18, 2004
Regulation of Cdx1 by Retinoid and wnt Signaling Pathways
February 11, 2004
Molecular Genetics of Animal Evolution
February 4, 2004
Ribosome Recruitment in Eukaryotes: Regulation of Gene Expression and Cell Growth
January 28, 2004
Mouse Models for Cancer
January 21, 2004
How to Make a Brain: Molecular Dissection of Neural Induction
January 14, 2004
Regulation of Snf1/AMPK Kinases and Responses to Metabolic Stress
January 7, 2004
Endoderm as a Source of Patterning Information for Early Chick Embryogenesis
December 10, 2003
Epithelial-Mesenchymal Cell Interactions and Branching Morphogenesis: The Mouse Lung as a Model System
December 3, 2003
Genetic Analysis of FGF Function in Mammalian Embryogenesis
November 19, 2003
Formation and Function of Boundaries in Hindbrain Patterning
November 12, 2003
Control of Motor Neuron Identity and Connectivity
November 5, 2003
Stem Cells and Developmental Pathways in the Early Mouse Embryo
October 29, 2003
Mechanisms of Chromosome Segregation
October 15, 2003
Taking the A(pical) Train: Mechanisms and Specificity of RNA Trafficking in Drosophila
October 1, 2003
Making Heads and Tails of the Early Embryo: TGFPathways Regulating Axis Formation in the Mouse
September 25, 2003
What my Mother Told Me: Maternal Control of Early Xenopus Development
September 24, 2003
Germ Cells
September 17, 2003
COX2 Inhibitors: From Discovery to Inflammation and Cancer
September 10, 2003
CK2 Regulation of Human RNA Polymerase III Transcription in a Well-Defined in vitro Transcription System
September 3, 2003
Bioinformatics of MicroRNAs
May 28, 2003
Genetic Dissection of Branching Morphogenesis
May 22, 2003
Retroviral Tagging Provides a Potent Cancer Gene Discovery Tool in the Post-genome Era
May 21, 2003
A Genetic Approach to the Study of Vesicle Transport in the Mouse
May 14, 2003
Chromosome Folding and Genome Stability
May 7, 2003
Combinatorial Mechanisms of Transcriptional Regulation in Human Cells
April 23, 2003
Germ Line Stem Cell Development in Drosophila
April 16, 2003
Reciprocal Coupling of Metabolism and Circadian Rhythm
April 9, 2003
Prions: How Strange Diseases and Strange Genetics Produce New Paradigms in Biology
April 2, 2003
A Molecular Model for Mechanosensation in C. elegans
March 26, 2003
Polarization of the Drosophila Oocyte
March 19, 2003
Life's a Niche: Regulation Stem Cell Self-Renewal and Differentiation
March 12, 2003
Regulation and Function of TGFß Signals during early Embryonic Patterning
March 4, 2003
Mouse Mutagenesis: Defining Gene Function and Modeling Human Disease
February 26, 2003
Mammary, Muscle, and Bone Marrow Stem Cells - Biology and Potential Plasticity
February 19, 2003
Forward Genetics in the Mouse: Gene Discovery and Functional Analysis of Circadian and Brain Pathways
February 12, 2003
Calcium-regulated Signaling Pathways Control Cellular Mass, Mitochondrial Biogenesis and Gene Expression in Cardiac and Skeletal Myocytes
February 5, 2003
The Control of Signaling through the EGF Receptor in Drosophila Oogenesis
January 29, 2003
Monitoring Synapses in Living Animals
January 22, 2003
Evolution and Dynamics of Variant H3 Histones
January 15, 2003
Ribosome Recruitment in Eukaryotes: Regulation of Gene Expression and Cell Growth
January 8, 2003
Exploring Chromosome Structure by Studying Recombination
December 11, 2002
Viewing Programmed Cell Death and Oncogenesis through the Eye of a Fly
December 4, 2002
Genetic and Molecular Studies on Stem Cell Regulation in Drosophila
November 20, 2002
Molecular Control of Human ß-globin Gene Switching
November 13, 2002
Ca2+ Regulation of Synapse Function
November 6, 2002
Axonal Organization in the Nervous System Relies on a Dedicated Maintenance Mechanism
October 30, 2002
Chemotaxis and its Role in Gastrulation in the Chick
October 23, 2002
Activation and Repression of Transcription by RNA Polymerase III
October 16, 2002
Functional Genomics in Drosophila: Highthroughput RNAi Screens in Drosophila Cells
October 9, 2002
Genetic Regulation of Genome Stability in Yeast
October 2, 2002
Connections Between Transcription and RNA Processing
September 25, 2002
Induction of the Neural Crest
September 18, 2002
Genetic Defenses Against Sterol Accumulation
September 11, 2002
Demagoguery, Ideology, and Rhetoric: The Politics of Stem Cell Research
September 4, 2002
Signal Transduction Mechanisms Guiding Cell Migration in the Nervous System
May 29, 2002
New Avenues in MAP Kinase Signal Transduction
May 22, 2002
Hox Protein Mutation and Macroevolution of the Insect Body Plan
May 15, 2002
Functions and Interactions of Histone Acetyltransferase Complexes and the SWI/SNF Complex in Yeast
May 8, 2002
Hedgehog Signaling in the Vertebrate Embryo
May 1, 2002
Exploring the Cellular Mechanism of Prion Disease: Misfolding and Retrograde Transport of PrP Generates a Neurotoxic PrPSc-like Conformation
April 24, 2002
Programming the Embryo to Make Blood and Vascular Endothelial Cells
April 17, 2002
Signaling Pathways that Regulate Synaptic Transmission in Brain
April 10, 2002
Functional Analysis of the Mammalian Genome
April 3, 2002
Transcriptional Control of Heart Development and Disease
March 27, 2002
The Ultrastructural Basis of Cancer Cell Invasiveness
March 20, 2002
How the Zebrafish Gets its Stripes
March 13, 2002
Pivotal Roles of Redox Regulation in Precursor Cell Function and Neoplasia
March 6, 2002
Insulators: A New Class of Elements that Establish Independent Domains of Gene Function
February 27, 2002
Development, Regeneration and Tumorigenesis: Mechanistic Insights from Gene Targeting and Expression Profiling
February 20, 2002
Regulation of Transcription in Animal Cells through the Action of Diverse Coactivators
February 13, 2002
How Cells Control Cholesterol
February 6, 2002
FGF and FGF Receptor Signaling in Skeletal Development and Genetic Disease
January 23, 2002
Experimental and Computational Methods for Identifying Regulatory Sites in DNA Sequences
January 16, 2002
Heparan Sulfate Proteoglycans: Master Regulators of Cellular Responsiveness to Growth Factors and Morphogens
January 9, 2002
Mapping Genome Regulatory Circuitry
December 12, 2001
Synapse Formation Analyzed in Fluorescent and Mutant Mice
December 5, 2001
Using Yeast to Analyze the Interactions of Proteins, Nucleic Acids and Small Molecules
November 28, 2001
COMPASS: A SET Domain Containing Trithorax Related Complex Involved in Transcriptional Regulation and Oncogenesis
November 14, 2001
Drosophila as a Model for Human Neurodegenerative Disease
November 7, 2001
Gulf War Syndrome: A Toxic Cellular Inquiry to Deep Brain Structures
October 24, 2001
Regulating the Strength of Synapses through Trafficking of Glutamate Receptors
October 17, 2001
Genetics of Development and Longevity in C. elegans
October 10, 2001
Structure and Function of Centromeric Chromatin in Flies and Humans
October 3, 2001
Biochemistry of Leukocyte-Endothelial Interactions
September 26, 2001
Chemical Biology of Intracellular Transition Metals in Human Disease
September 19, 2001
Proteomic and Genetic Approaches to studies of Regulated Protein Secretion to Anticancer Drugs
September 5, 2001
Regulation of Cell Differentiation During Early Stages of Drosophila Oogenesis
June 6, 2001
May 30, 2001
Hox Genes and the Arthopodan Bauplan
May 16, 2001
Vertebrate Segmentation and Pattern Formation
May 9, 2001
Comparative Genomics: A New Tool for Studying Genome Function and Evolution
May 2, 2001
Neurotrophin Ligands and their Receptors in the Survival of Early Neurons
April 11, 2001
Conformational Neurodegenerative Diseases: Role of Proteases and Transglutaminases in Model Systems
March 28, 2001
Mutation Accumulation in the c.Elegans Genome
March 21, 2001
Hoxc 13: Hair Today, Gone Tomorrow
March 14, 2001
Mouse Genetics in the Context of a Mouse Model of SLE
March 7, 2001
Regulation of Transcription during Endoderm Development in Sea Urchins
February 28, 2001
Molecular Signaling in Embryo-Uterine Interactions During Implantation
February 21, 2001
Molecular Mechanism of Chemoprevention by the Bioflavonoid Apigenin: Post-translational Stabilization of the p53 Tumor Suppressor Protein
February 14, 2001
Informatics and Instrumentation for the Post-genome Era
February 7, 2001
Doubletime: A Protein Kinase that Establishes the Molecular Oscillations of Circadian Rhythms
January 31, 2001
Mechanisms of Regulation of Gene Expression by Zinc
January 24, 2001
Vasculogenesis: Formation of the First Blood Vessels
January 10, 2001
Cre Recombinase and Mouse Genetics by Design
December 4, 2000
Craniofacial Development: The Role of Neural Crest and Hox Gene Plasticity
November 29, 2000
Roles for Hsp70 in CFTR Folding and Proteosomal Degradation
