Past Wednesday Lectures

January 13, 2021
Antonis Rokas - Vanderbilt University
Fantastic Yeasts and How They Evolved to Be
December 9, 2020
Simón Méndez-Ferrer - Wellcome Trust MRC Cambridge Stem Cell Institute
Changing neighborhoods: bone marrow stem-cell niche remodeling during age-related myeloid malignancies​
December 2, 2020
Bruce Spiegelman - Dana-Farber Cancer Institute, HHMI
Brown and Beige Fat: Basic Science and New Therapeutic Opportunities​
November 25, 2020
Andreas Schaefer - The Francis Crick Institute
From synchrontrons to microwires - an interdisciplinary view on sensory processing
November 18, 2020
Jan Huisken - Morgridge Institute for Research
Scale-bridging in vivo studies of vertebrate embryogenesis with compact, modular light sheet microscopes
November 4, 2020
Manolis Kellis - Massachusetts Institute of Technology
From genomics to therapeutics: single-cell dissection and manipulation of disease circuitry
October 28, 2020
Hopi Hoekstra - Harvard University
A tale of tails: the genetic and developmental basis of evolutionary change
October 21, 2020
Irene Miguel-Aliaga - MRC London Institute of Medical Sciences
Sex differences in organ plasticity
October 14, 2020
Emmanuel Levy - Weizmann Institute of Science
Principles of protein assembly in cells
October 7, 2020
Jesse Bloom - Fred Hutchinson Cancer Research Center
The evolutionary potential of the SARS-coV-2 receptor binding domain
September 30, 2020
Liam Holt - New York University, Langone Health
Crowd Control
September 23, 2020
Monica Colaiacovo - Harvard University
Location and numbers: how recombination and our chemical landscape converge on meiosis
September 16, 2020
Oscar Marin Parra - MRC Centre for Neurodevelopmental Disorders Centre for Developmental Neurobiology
Molecular mechanisms of cortical interneuron diversity and plasticity
May 20, 2020
Francesca Cole - MD Anderson - (Virtual seminar)
How chromosome structure and recombination ensure homolog segregation in mammalian meiosis
May 13, 2020
Phil Newmark - Morgridge Institute - (Virtual seminar)
From planarians to parasites: stem cell-driven developmental transitions in schistosomes
May 6, 2020
Kausik Si - Stowers Institute for Medical Research - (Virtual seminar)
Out of one, many: memory and the plasticity of proteins
April 29, 2020
Amy Gladfelter - University of North Carolina at Chapel Hill - (Virtual Seminar)
How cells sense and create shape
April 22, 2020
Scott Hawley - Stowers Institute for Medical Research - (Virtual seminar)
Meiotic Legos: Many Forms & Many Functions of the Synaptonemal Complex
April 15, 2020
Trisha Davis - University of Washington
April 8, 2020
Hopi Hoekstra - Harvard University
April 1, 2020
Eric Klann - New York University
March 25, 2020
Andreas Schaefer - The Francis Crick Institute
March 18, 2020
Amanda Larracuente - University of Rochester
March 11, 2020
Alejandro Sanchez Alvarado - Stowers Institute
March 4, 2020
Davide Ruggero - University of California, San Francisco
Decoding the cancer genome one condon at a time and its therapeutic implications
February 26, 2020
William Kaelin - Dana-Farber Cancer Institute
The VHL Tumor Suppressor Gene: Bedside to Bench to Bedside
February 19, 2020
Judy Campisi - The Buck Institute
Cancer and aging: Rival demons?
February 5, 2020
Leslie Leinwand - University of Colorado, Boulder
Myosin myopathies: pathogenesis and therapeutic potential
January 29, 2020
Amita Sehgal - University of Pennsylvania
How Circadian Rhythms & Sleep Impact Physiology
January 22, 2020
Gary Lewin - Max Delbruck Center for Molecular Medicine
Seminar Cancelled due to weather-- Neurobiology in extremis: molecular exploitation of extremeophile mammals
January 15, 2020
Valentina Greco - Yale University
Principles of organ regeneration discovered by live imaging
January 8, 2020
Fan Wang - Duke University
Anesthesia, sleep, and pain
December 11, 2019
Annika Guse - Heidelberg University, Centre for Organismal Studies, Germany
Molecular Mechanisms of Coral-Algal Endosymbiosis
December 4, 2019
Patrick Lemaire - French National Centre for Scientific Research
Cell-whispering: extreme morphogenetic reproducibility of ascidian embryogenesis despite extensive genetic divergence
November 20, 2019
Tatjana Sauka-Spengler - MRC Weatherall Institute of Molecular Medicine
Reverse engineering of the global Neural Crest Gene Regulatory Network in vivo
November 13, 2019
Deneen Wellik - University of Wisconsin
This seminar is cancelled
November 6, 2019
Don Fox - Duke University Medical Center
Polyploidy: a key player in building and repairing organs
October 30, 2019
Samantha Morris - Washington University
Single-cell recording of lineage and transcriptional regulation in direct reprogramming
October 23, 2019
Cole Trapnell - University of Washington
Massively multiplex chemical transcriptomics at single-cell resolution
October 16, 2019
Anshul Kundaje - Stanford University
Interpretable deep learning for regulatory genomics
October 9, 2019
Bonnie Bassler - Princeton University
Quorum-Sensing Communication: From Viruses to Bacteria to Eukaryotes
October 2, 2019
Bruce Walker - Harvard University
T cell control of HIV: Implications for vaccines and cure
September 25, 2019
Bin Wu - Johns Hopkins School of Medicine
Central dogma in live cells, imaging and manipulating single alleles and single mRNAs
September 18, 2019
George Prendergast - Lankenau Institute for Medical Research
Why Tumors Eat Tryptophan: Immunometabolism, Vascularization and Metastasis
September 11, 2019
Zhijian (James) Chen - University of Texas, Southwestern
The dark side of DNA - how DNA triggers immune defense and autoimmune diseases
September 4, 2019
Brian McStay - Centre for Chromosome Biology Biomedical Sciences
Nucleolar formation in human cells; a chromosomal perspective
May 22, 2019
Yukiko Yamashita - University of Michigan
Asymmetric cell division and germline immortality
May 15, 2019
Ibrahim Cisse - Massachusetts Institute of Technology
Super-resolution imaging of transcription in live mammalian cells
May 8, 2019
Amy MacQueen - Wesleyan University
Zippers and Stitches in the Meiotic Nucleus
May 2, 2019
Gloria Brar - University of California, Berkeley
Regulated transcript toggling and protein degradation set meiotic protein levels
April 24, 2019
Laurie Parker - University of Minnesota
Building a toolkit for studying the orphan kinome
April 17, 2019
Neil Shubin - University of Chicago
Fossils, Genes and the Origins of Limbs
April 10, 2019
Adam Phillippy - National Human Genome Research Institute (NHGRI)
Perfecting human genome assembly with ultra-long-read nanopore sequencing
April 3, 2019
Josh LaBaer - Arizona State University
Exploring the Proteome Using Functional Protein Microarrays
March 27, 2019
Evangel Nogales De La Morena - University of California, Berkeley
Complex dynamics at the heart of the transcription initiation process
March 20, 2019
Judit Villén - University of Washington
New technologies to interrogate the dynamics and function of the phosphoproteome
March 13, 2019
Jean-Marc Egly - Institute of Genetics and Molecular and Cellular Biology
The Transcription DNA repair connection starts at the promoter
March 6, 2019
Steve Ramirez - Boston University
Artificially manipulating positive and negative memories in healthy and maladaptive states
February 27, 2019
Xiaozhong Alec Wang - Northwestern University
A chemical biology approach to mapping the nucleosome landscape in mammalian stem cells
February 20, 2019
Sharon Dent - MD Anderson University of Texas
An Update on SAGA Functions in Development and Disease
February 13, 2019
Roy Jensen - University of Kansas Cancer Center
The BRCA1-EGFR Axis in Breast Cancer
February 6, 2019
Michael Lampson - University of Pennsylvania
Violation of Mendel's First Law: chromosome competition in meiosis
January 30, 2019
Marc Timmers - DKFZ-Freiburg Germany
Basal transcription factor TFIID: epigenetics, stem cells and assembly
January 16, 2019
Iain Cheeseman - Whitehead Institute for Biomedical Research
From hibernation to proliferation: Modulating centromere and kinetochore function across cell state
December 12, 2018
David Hu - Georgia Institute of Technology
The cat's tongue and other mysteries of animal movement
December 5, 2018
David Sherwood - Duke University
Cell invasion and basement membrane dynamics in C elegans
November 28, 2018
Lionel Christiaen - New York University
Regulation of cardiopharyngeal fates in chordates
November 14, 2018
Neil Segil - University of Southern California
Epigenetics of development and the failure of regeneration in the mammalian inner ear
November 7, 2018
Ralph Marcucio - University of California, San Francisco
The Death of Dogma, and the Transformation of Chondrocytes to Osteoblasts
October 31, 2018
Ahna Skop - University of Wisconsin, Madison
What is the connection between cell division and neurodegenerative disease?
October 24, 2018
Stirling Churchman - Harvard Medical Center
Checks and balances in orchestrating global gene regulation
October 17, 2018
Justin Fay - University of Rochester
Domestication of a beast of a yeast
October 11, 2018
Angela DePace - Harvard Medical School
Precision and Plasticity in Animal Transcription
October 3, 2018
Jacques Cote - Laval University Cancer Research Center
Reading and writing histone marks in genome expression/maintenance and cancer
September 26, 2018
Ted Abel - University of Iowa
Molecular Mechanisms of Long-Term Memory Storage
September 19, 2018
Jordan Meier - National Cancer Institute-Frederick
New insights into acetylation & oncometabolism from chemoproteomics
September 12, 2018
Ehab Abouheif - McGill University
What soldier and supersoldier ants teach us about development and evolution
September 5, 2018
Rahul Satija - New York University
Integrated analysis of single cell data across modalities, technologies, and species
May 30, 2018
Nicolas Gompel - Ludwig-Maximilians-University of Munich
Regulatory evolution and the diversification of pigmentation patterns in Drosophila
May 23, 2018
Yves Barral - ETH Zurich
Yeast aging as a model for understanding genomic immunity in eukaryotes
May 9, 2018
Wei Yang - National Institutes of Health
Seeing is believing: mechanism for genome maintenance
May 2, 2018
Sue Ackerman - University of California, San Diego
Defects in mRNA translation and neurological disease
April 25, 2018
Antonio Giraldez - Yale University
Deciphering the regulatory codes shaping the maternal to zygotic transition during development
April 18, 2018
Sadie Wignall - Northwestern University
Building a spindle and segregating chromosomes without centrosomes: Oocyte meiosis in C. elegans
April 11, 2018
John Tomich - Kansas State University
Peptide Bilayer-Now Really? What's Next?
April 4, 2018
Utpal Banerjee - University of California, Los Angeles
Metabolic Control of Mammalian Embryonic Development
March 28, 2018
Norbert Perrimon - Harvard Medical School
Interorgan communication
March 21, 2018
Beth Sullivan - Duke University
Genomic and epigenetic variation controls human centromere function
March 14, 2018
Mark Krasnow - Stanford University
Elucidating lung stems cells and cancer initiation at single cell resolution
March 7, 2018
Alexander Schier - Harvard University
Induction and lineage in vertebrate development: insights from zebrafish
February 21, 2018
Scott Keeney - Memorial Sloan Kettering Cancer Center
Breaking PAR: Sex chromosome recombination in mouse male meiosis
February 14, 2018
Richard Morimoto - Northwestern University
The Biology of Proteostasis in Aging and Neurodegenerative Diseases
January 17, 2018
Doris Bachtrog - University of California, Berkeley
Sex chromosomes, chromatin sinks & sex-specific development & aging
December 13, 2017
Tom Misteli - National Cancer Institute
Deep Imaging of the Genome
December 6, 2017
Timothy Saunders - National University of Singapore
Exploring the spatiotemporal dynamics of morphogen gradient formation and signaling
November 29, 2017
Hans Schöler - Max Planck Institute for Molecular Biomedicine in Müenster
Induction of pluripotent and multipotent stem cells
November 15, 2017
Angelika Amon - Massachusetts Institute of Technology
The Causes and Consequences of Anueploidy
November 8, 2017
Tom Curran - Children's Research Institute
Developing Hedgehog Pathway Inhibitors to Treat Pediatric Brain Tumors: How Basic Science Drives Translation
October 25, 2017
Nipam Patel - University of California, Berkeley
Evolution and Development: Insights from Emerging Model Systems
October 18, 2017
Michael Galko - University of Texas
Flying Wounded: Using Drosophila to study tissue repair responses
October 4, 2017
Richard Mann - Columbia University
Scratching beneath the surface of transcription factor-DNA recognition
September 27, 2017
Kevin White - University of Chicago
From Petabytes to Molecular Insights: Building an Operating System for Cancer
September 20, 2017
Nicolas Rohner - Stowers Institute For Medical Research
Bringing light into dark, how cavefish illuminate medicine and evolution
September 13, 2017
Ian Willis - Albert Einstein College of Medicine
Metabolic Impact of Unrestrained Transcription by RNA Polymerase III
September 6, 2017
Eric Kmiec - The Gene Institute - Helen F. Graham Cancer Center & Research Institute
Historical Development and Cellular Regulation of CRISPR-based Gene Editing in Human Cells
May 24, 2017
John Postlethwait - University of Oregon
Genomic revolutions: Antarctic fish and the teleost genome duplication
May 17, 2017
Cassandra Extavour - Harvard University
Alternative model organisms: new tools, new insights into the evolution of development
May 10, 2017
Joel Richter - University of Massachusetts Medical Center
Translational Control of Neurologic Disease
May 3, 2017
Allan Drummond - University of Chicago
How phase separation helps cells react to stress
April 26, 2017
James Briscoe - The Francis Crick Center
The gene regulatory logic of vertebrate neural tube development
April 19, 2017
Steven Pruitt - Rosewell Park Cancer Institute
DNA Replication Licensing in Genome Stability and Cancer
April 12, 2017
Chris Lowe - Stanford University
Uncoupling the evolution of morphology and regulatory networks during the evolution of nervous systems
April 5, 2017
Brian Slaughter and Jay Unruh - Stowers Institute For Medical Reseaerch
In Situ Structural Biology: Expansion, Super-resolution, and Image averaging
March 29, 2017
Jonathan Weissman - HHMI, University of California, San Francisco
Controlling the volume of gene expression with CRISPRi and CRISPRa
March 22, 2017
Monica Bettencourt Dias - Instituto Gulbenkian de Ciencia
Centrosomes in Development, Evolution and Disease
March 15, 2017
Fiona Watt - University of Oxford
Regulating exit from the stem cell compartment in mammalian epidermis
March 8, 2017
Susan Dutcher - Washington University, St. Louis
Dissecting the assembly of cilia
March 1, 2017
Christopher Gregg - University of Utah
Epigenetic Allelic Effects and Computational Ethology: New Paradigms in Behavioral Genetics