Ma R, Wu Y, Zhai Y, Hu B, Ma W, Yang W, Yu Q, Chen Z, Workman JL, Yu X, Li S. Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT-NAD+-SIRT1 pathway. Nucleic Acids Res. 2019; 47(21):11132-11150. Abstract
Soffers JMH, Li X, Saraf A, Seidel CW, Florens L, Washburn MP, Abmayr SM, Workman JL. Characterization of a metazoan ADA acetyltransferase complex. Nucleic Acids Res. 2019;47 (7), 3383-3394. Abstract | Original Data
Mei Q, Xu C, Gogol M, Tang J, Chen W, Yu X, Workman JL, Li S. Set1-catalyzed H3K4 trimethylation antagonizes the HIR/Asf1/Rtt106 repressor complex to promote histone gene expression and chronological life span. Nucleic Acids Res.2019. Abstract
Suganuma, T., Swanson, SK., Gogol, MM., Garrett, TJ., Conkright-Fincham, J. Florens, L., Washburn, MP., Workman J.L. MPTAC Determines APP Fragmentation via Sensing Sulfur Amino Acid Catabolism, Cell reports. 2018;24 (6), 1585-1596. Abstract | Original Data
Oh, S., Suganuma, T., Gogol, MM., Workman J.L. Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress respons. Elife 7.2018; e36157. Abstract | Original Data
Suganuma T, Workman JL. Chromatin and Metabolism. Annu Rev Biochem. 2018;20;87:27-49. Abstract
Li X, Seidel CW, Szerszen LT, Lange JJ, Workman JL, Abmayr SM. Enzymatic modules of the SAGA chromatin-modifying complex play distinct roles in Drosophila gene expression and development. Genes Dev.2017;31:1588-1600. Abstract | Original Data
Dutta A, Sardiu M, Gogol M, Gilmore J, Zhang D, Florens L, Abmayr SM, Washburn MP, Workman JL. Composition and Function of Mutant Swi/Snf Complexes. Cell Rep.2017;18:2124-2134. Abstract | Original Data
Hepp MI, Smolle M, Gidi C, Amigo R, Valenzuela N, Arriagada A, Maureira A, Gogol MM, Torrejon M, Workman JL, Gutierrez JL. Role of Nhp6 and Hmo1 in SWI/SNF occupancy and nucleosome landscape at gene regulatory regions. Biochim Biophys Acta.2017;1860:316-326. Abstract | Original Data
Lee J, Shik Choi E, David Seo H, Kang K, Gilmore JM, Florens L, Washburn MP, Choe J, Workman JL, Lee D. Chromatin remodeller Fun30Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation. Nat Commun.2017;8:14527. doi: 14510.11038/ncomms14527. Abstract | Original Data
Soffers JH, Li X, Abmayr SM, Workman JL. Reading and Interpreting the Histone Acylation Code. Genomics Proteomics Bioinformatics.2016;14:329-332. Abstract | Original Data
Dyer JO, Dutta A, Gogol M, Weake VM, Dialynas G, Wu X, Seidel C, Zhang Y, Florens L, Washburn MP, Abmayr SM, Workman JL. Myeloid Leukemia Factor Acts in a Chaperone Complex to Regulate Transcription Factor Stability and Gene Expression. J Mol Biol.2017;429:2093-2107. Abstract | Original Data
Venkatesh S, Li H, Gogol MM, Workman JL. Selective suppression of antisense transcription by Set2-mediated H3K36 methylation. Nat Commun.2016;7:e13610. doi: 13610.11038/ncomms13610. Abstract | Original Data
Lan X, Atanassov BS, Li W, Zhang Y, Florens L, Mohan RD, Galardy PJ, Washburn MP, Workman JL, Dent SY. USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B. Cell Rep.2016;17:2382-2393. Abstract | Original Data
Dutta A, Workman JL. In Vitro Assembly of Nucleosomes for Binding/Remodeling Assays. Methods Mol Biol.2017;1528:1-17. Abstract | Original Data
Li W, Atanassov BS, Lan X, Mohan RD, Swanson SK, Farria AT, Florens L, Washburn MP, Workman JL, Dent SY. Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module. Mol Cell Biol.2016;36:2855-2866. Abstract | Original Data
Dutta A, Abmayr SM, Workman JL. Diverse Activities of Histone Acylations Connect Metabolism to Chromatin Function. Mol Cell.2016;63:547-552. Abstract | Original Data
Lei K, Thi-Kim Vu H, Mohan RD, McKinney SA, Seidel CW, Alexander R, Gotting K, Workman JL, Sánchez Alvarado A. Egf Signaling Directs Neoblast Repopulation by Regulating Asymmetric Cell Division in Planarians. Dev Cell.2016;38:413-429. Abstract | Original Data
Huang F, Abmayr SM, Workman JL. Limiting PCNA-unloading at the G1/S transition. Cell Cycle.2016;15:3001-3002. Abstract | Original Data
Gilmore JM, Sardiu ME, Groppe BD, Thornton JL, Liu X, Dayebgadoh G, Banks CA, Slaughter BD, Unruh JR, Workman JL, Florens L, Washburn MP. WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage. PloS One.2016;11:e0155492. doi: 0155410.0151371/journal.pone.0155492. Abstract | Original Data
Huang F, Saraf A, Florens L, Kusch T, Swanson SK, Szerszen LT, Li G, Dutta A, Washburn MP, Abmayr SM, Workman JL. The Enok acetyltransferase complex interacts with Elg1 and negatively regulates PCNA unloading to promote the G1/S transition. Genes Dev.2016;30:1198-1210. Abstract | Original Data
Huang F, Abmayr SM, Workman JL. Regulation of KAT6 Acetyltransferases and Their Roles in Cell Cycle Progression, Stem Cell Maintenance, and Human Disease. Mol Cell Biol.2016;36:1900-1907. Abstract | Original Data
Atanassov BS, Mohan RD, Lan X, Kuang X, Lu Y, Lin K, McIvor E, Li W, Zhang Y, Florens L, Byrum SD, Mackintosh SG, Calhoun-Davis T, Koutelou E, Wang L, Tang DG, Tackett AJ, Washburn MP, Workman JL, Dent SY. ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth. Mol Cell.2016;62:558-571. Abstract | Original Data
Workman JL. CHROMATIN. It takes teamwork to modify chromatin. Science.2016;351:667. Abstract | Original Data
Suganuma T, Workman JL. Histone modification as a reflection of metabolism. Cell Cycle.2016;15:481-482. Abstract | Original Data
Suganuma T, Swanson SK, Florens L, Washburn MP, Workman JL. Moco biosynthesis and the ATAC acetyltransferase engage translation initiation by inhibiting latent PKR activity. J Mol Cell Biol.2016;8:44-50. Abstract | Original Data
Huang F, Paulson A, Dutta A, Venkatesh S, Smolle M, Abmayr SM, Workman JL. Histone acetyltransferase Enok regulates oocyte polarization by promoting expression of the actin nucleation factor spire. Genes & Dev.2014;28:2750-2763. Abstract | Original Data
Dutta A, Gogol M, Kim JH, Smolle M, Venkatesh S, Gilmore J, Florens L, Washburn MP, Workman JL. Swi/Snf dynamics on stress-responsive genes is governed by competitive bromodomain interactions. Genes Dev.2014;29:2314-2330. Abstract
Sardiu ME, Smith KT, Groppe BD, Gilmore JM, Saraf A, Egidy R, Peak A, Seidel C, Florens L, Workman JL, Washburn MP. SAHA Induced Dynamics of a Human Histone Deacetylase Protein Interaction Network [published ahead of print July 29 2014]. Mol Cell Proteomics. 2014. Abstract | Original Data
Mohan RD, Dialynas G, Weake VM, Liu J, Martin-Brown S, Florens L, Washburn MP, Workman JL, Abmayr SM. Loss of Drosophila Ataxin-7, a SAGA subunit, reduces H2B ubiquitination and leads to neural and retinal degeneration. Genes Dev. 2014;28:259-272. Abstract | Original Data
Mosley AL, Hunter GO, Sardiu ME, Smolle M, Workman JL, Florens L, Washburn MP. Quantitative Proteomics Demonstrates That the RNA Polymerase II Subunits Rpb4 and Rpb7 Dissociate during Transcriptional Elongation. Mol Cell Proteomics. 2013;12:1530-1538. Abstract | Original Data
Smith KT, Sardiu ME, Martin-Brown SA, Seidel C, Mushegian A, Egidy R, Florens L, Washburn MP, Workman JL. Human Family with Sequence Similarity 60 Member A (FAM60A) Protein: a New Subunit of the Sin3 Deacetylase Complex. Mol Cell Proteomics.2012;11:1815-1828. Abstract
Smolle M, Venkatesh S, Gogol MM, Li H, Zhang Y, Florens L, Washburn MP, Workman JL. Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange. Nat Stuct Mol Biol. 2012;19:884-892. Abstract
Venkatesh S, Smolle M, Li H, Gogol MM, Saint M, Kumar S, Natarajan K, Workman JL. Set2 methylation of histone H3 lysine36 suppresses histone exchange on transcribed genes. Nature 2012;489:452-455. Abstract
Suganuma T, Mushegian A, Swanson SK, Florens L, Washburn MP, Workman JL. A metazoan ATAC acetyltransferase subunit that regulates MAP kinase signaling is related to an ancient molybdopterin synthase component. Mol Cell Proteomics.2012;11:90-99. Abstract | Original Data
Weake VM, Dyer JO, Seidel C, Box A, Swanson SK, Peak A, Florens L, Washburn MP, Abmayr SM, Workman JL. Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. Genes Dev.2011;25:1499-1509. Abstract
Mosley AL, Sardiu ME, Pattenden SG, Workman JL, Florens L, Washburn MP. Highly reproducible label free quantitative proteomic analysis of RNA polymerase complexes. Mol Cell Proteomics.2011;10:M110 000687. Abstract
Lee KK, Sardiu ME, Swanson SK, Gilmore JM, Torok M, Grant PA, Florens L, Workman JL, Washburn MP. Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes. Mol Syst Biol.2011;7:503. Abstract
Suganuma T, Mushegian A, Swanson SK, Abmayr SM, Florens L, Washburn MP, Workman JL. The ATAC acetyltransferase complex coordinates MAP kinases to regulate JNK target genes. Cell.2010;142:726-736. Abstract
Smith KT, Martin-Brown SA, Florens L, Washburn MP, Workman JL. Deacetylase inhibitors dissociate the histone-targeting ING2 subunit from the Sin3 complex. Chem Biol.2010;17:65-74. Abstract
Weake VM, Lee KK, Guelman S, Lin CH, Seidel C, Abmayr SM, Workman JL. SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system. Embo J.2008;27:394-405. Abstract
Suganuma T, Gutierrez JL, Li B, Florens L, Swanson SK, Washburn MP, Abmayr SM, Workman JL. ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding. Nat Struct Mol Biol.2008;15:364-372. Abstract
Li B, Gogol M, Carey M, Pattenden SG, Seidel C, Workman JL. Infrequently transcribed long genes depend on the Set2/Rpd3S pathway for accurate transcription. Genes Dev.2007;21:1422-1430. Abstract
Li B, Gogol M, Carey M, Lee D, Seidel C, Workman JL. Combined Action of PHD and Chromo Domains Directs the Rpd3S HDAC to Transcribed Chromatin. Science.2007;316:1050-1054. Abstract
Gutierrez JL, Chandy M, Carrozza MJ, Workman JL. Activation domains drive nucleosome eviction by SWI/SNF. Embo J.2007;26:730-740. Abstract
Carey M, Li B, Workman JL. RSC Exploits Histone Acetylation to Abrogate the Nucleosomal Block to RNA Polymerase II Elongation. Mol Cell.2006;24:481-487. Abstract
Carrozza MJ, Li B, Florens L, Suganuma T, Swanson SK, Lee KK, Shia WJ, Anderson S, Yates J, Washburn MP, Workman JL. Histone H3 Methylation by Set2 Directs Deacetylation of Coding Regions by Rpd3S to Suppress Spurious Intragenic Transcription. Cell.2005;123:581-592. Abstract
Kusch T, Florens L, Macdonald WH, Swanson SK, Glaser RL, Yates Iii JR, Abmayr SM, Washburn MP, Workman JL. Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science.2004;306:2084-2087. Abstract