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Laurence Florens

B.Sc., Biochemistry, Nice University
M.Sc., Cell Biology, Structural Biology, Microbiology, Aix-Marseilles University
Ph.D., Biochemistry, Structural Biology, Microbiology, Aix-Marseilles University

Courses Taught

Gene Expression: Transcription to Translation

Honors

2006

Co-recipient of the Hudson Prize from the M.R. and Evelyn Hudson Foundation

Laurence Florens established the Systems Mass Spectrometry Center, formerly known as Proteomics, at the Stowers Institute in July 2003 with Mike Washburn. Ever since, Florens has developed, adopted, and applied advanced mass spectrometry-based approaches to drive biological discovery in a wide array of collaborative projects, leading to over 250 peer-reviewed publications with 47 different labs.

A native of France, Florens graduated from Nice University with a B.S. in biochemistry. She received an M.S. and Ph.D. in structural biology and microbiology from Aix-Marseilles I University before completing a postdoctoral fellowship in bioenergetics at Michigan State University. Florens joined the lab of John R. Yates at The Scripps Research Institute, where she applied proteomics to the malaria parasite. While at the Stowers Institute, she has continued working on apicomplexan parasites’ proteomes via NIH-supported collaborations.

Florens is the 2006 co-recipient of the Hudson Prize from the M.R. and Evelyn Hudson Foundation. She has been a faculty member at the Graduate School of the Stowers Institute since its inception and serves on the Editorial Advisory Board for the Journal of Proteome Research, for which she is guest-editing a biennial special issue series on Methods for Omics Research.

Featured Publications

Structural basis of the interaction between SETD2 methyltransferase and hnRNP L paralogs for governing co-transcriptional splicing

Bhattacharya S, Wang S, Reddy D, Shen S, Zhang Y, Zhang N, Li H, Washburn MP, Florens L, Shi Y, Workman JL, Li F. Nat Commun. 2021;12:6452. doi: 6410.1038/s41467-41021-26799-41463.

MOCS2 links nucleotide metabolism to nucleoli function

Suganuma T, Swanson SK, Gogol M, Garrett TJ, Florens L, Workman JL. J Mol Cell Biol. 2022;13:838-840.

Multiple roles for PARP1 in ALC1-dependent nucleosome remodeling

Ooi SK, Sato S, Tomomori-Sato C, Zhang Y, Wen Z, Banks CAS, Washburn MP, Unruh JR, Florens L, Conaway RC, Conaway JW.  Proc Natl Acad Sci U S A. 2021;118:e2107277118. doi: 2107277110.2107271073/pnas.2107277118.

Proteome plasticity in response to persistent environmental change

Domnauer M, Zheng F, Li L, Zhang Y, Chang CE, Unruh JR, Conkright-Fincham J, McCroskey S, Florens L, Zhang Y, Seidel C, Fong B, Schilling B, Sharma R, Ramanathan A, Si K, Zhou C. Mol Cell. 2021;81:3294-3309 e3212.

Decellularization enables functional analysis of ECM remodeling in planarian regeneration

Sonpho E, Mann FG, Jr., Levy M, Ross EJ, Guerrero-Hernandez C, Florens L, Saraf A, Doddihal V, Ounjai P, Sánchez Alvarado A. Mol Cell Proteomics. 2021:100137.  doi: 100110.101016/j.mcpro.102021.100137.

Genome-Wide Binding Analyses of HOXB1 Revealed a Novel DNA Binding Motif Associated with Gene Repression

Singh NP, De Kumar B, Paulson A, Parrish ME, Scott C, Zhang Y, Florens L, Krumlauf R. [published ahead of print March 4 2021]. Dev Biol. 2021;9.

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