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Alejandro Sánchez Alvarado

B.S., Molecular Biology and Chemistry, Vanderbilt University
Ph.D., Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine

I envision a future in which our interrogation of nature will not only continue to unveil new biology, but will also result in the discovery of altogether new principles of biology.

Research Areas

Development and Regeneration, Genetics and Genomics, Evolutionary Biology, Molecular and Cell Biology

Courses Taught

Cell Biology; Evolution and Model Systems; Laboratory Rotation; Thesis Laboratory

Honors

2022

Priscilla Wood Neaves Chair in the Biomedical Sciences

2018

Member, National Academy of Sciences

2017

Member, Latin American Academy of Sciences

2015

Member, American Academy of Arts and Sciences

2009

National Institutes of Health, MERIT Award

2009

Ellison Medical Foundation Senior Scholar

2008

National Academy of Sciences Kavli Fellow

Alejandro Sánchez Alvarado, Ph.D., is the Executive Director and Chief Scientific Officer of the Stowers Institute. Alejandro joined the Institute in 2011, was named its Scientific Director in 2019, and named Executive Director and Chief Scientific Officer in 2021.

Growing up in Caracas, Venezuela, Sánchez Alvarado moved from Venezuela to the United States to study molecular biology and chemistry at Vanderbilt University in Nashville, and then at the University of Cincinnati College of Medicine, where he earned his Ph.D. in pharmacology and cell biophysics. In 1994, he joined the laboratory of Donald D. Brown, M.D., in the department of embryology at the Carnegie Institution of Washington as a postdoctoral fellow. In 1995, he was appointed to the position of staff associate. It was during this period that Sánchez Alvarado developed his abiding interest in explaining the processes of regeneration.

Not satisfied with the available research organisms, he went looking for a better one, subsequently setting his sights on the planarian. On a trip to Barcelona with his first postdoctoral researcher, Phil Newmark, Ph.D., they collected a unique strain of the planaria Schmidtea mediterranea in an abandoned fountain. Sánchez Alvarado was able to subsequently establish the planaria as a modern research animal, studied by multiple other investigators. The Planarian Core in the Reptile and Aquatics Facility at the Stowers Institute now furnishes planaria to researchers and educators across the globe.

From 2002 to 2011, Sánchez Alvarado was a faculty member in the Department of Neurobiology and Anatomy at the University of Utah School of Medicine. In 2005, he was named an Investigator of the Howard Hughes Medical Institute (HHMI). Sánchez Alvarado is a member of the National Academy of Sciences and a lifetime fellow for the American Association for the advancement of Science (AAAS). He is a recipient of the Priscilla Wood Neaves Endowed Chair in the Biomedical Sciences.

Sánchez Alvarado speaks at conferences and seminars worldwide and serves on multiple local, regional and national boards, including the Nelson Atkins Museum of Art, Linda Hall Library and KCUR in Kansas City.

Featured Publications

Hox genes regulate asexual reproductive behavior and tissue segmentation in adult animals

Arnold CP, Lozano AM, Mann FG, Jr., Nowotarski SH, Haug JO, Lange JJ, Seidel CW, Sánchez Alvarado A. Nat Commun. 2021;12:6706. doi: 6710.1038/s41467-41021-26986-41462.

Identification of rare, transient post-mitotic cell states that are induced by injury and required for whole-body regeneration in Schmidtea mediterranea

Benham-Pyle BW, Brewster CE, Kent AM, Mann FG, Jr., Chen S, Scott AR, Box AC, Sánchez Alvarado A. Nat Cell Biol. 2021;23:939-952.

Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates

Wang W, Hu CK, Zeng A, Alegre D, Hu D, Gotting K, Ortega Granillo A, Wang Y, Robb S, Schnittker R, Zhang S, Alegre D, Li H, Ross E, Zhang N, Brunet A, Sanchez Alvarado A. Science. 2020;369: eaaz3090. doi: 10.1126/science.aaz3090.

Wnt and TGF-β coordinate growth and patterning to regulate size-dependent behavior

Arnold CP, Benham-Pyle BW, Lange JJ, Wood CJ, Sánchez Alvarado A. Nature. 2019;572:655-659.

Prospectively Isolated Tetraspanin(+) Neoblasts Are Adult Pluripotent Stem Cells Underlying Planaria Regeneration

Zeng A, Li H, Guo L, Gao X, McKinney S, Wang Y, Yu Z, Park J, Semerad C, Ross E, Cheng LC, Davies E, Lei K, Wang W, Perera A, Hall K, Peak A, Box A, Sánchez Alvarado A. Cell. 2018;173:1593-1608.e20.

Molecular characterization of a flatworm Girardia isolate from Guanajuato, Mexico

Duncan EM, Nowotarski SH, Guerrero-Hernandez C, Ross EJ, D'Orazio JA, Clubes de Ciencia Mexico Workshop for Developmental B. [published ahead of print June 17 2022]. Dev Biol 2022.

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